Coencapsulation of cyclodextrins into poly(anhydride) nanoparticles to improve the oral administration of glibenclamide. A screening on C. elegans

Lucio, David; Martínez-Ohárriz, María Cristina; González-Navarro, Carlos J.; Navarro‐Herrera, David; González‐Gaitano, Gustavo; Rădulescu, Aurel

doi:10.1016/j.colsurfb.2017.12.038

Cited by 8 publications

(2 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This material is marketed by Ashland Inc. as Gantrez ® and presents suitable properties for biomedical applications (low toxicity, high biocompatibility, high mucoadhesivity and low cost). In particular, it is reported that PMVE/MA can be structured as loadable nanoparticles [9] and its derivates poly(methyl vinyl ether-alt-maleic acid) (PMVE/MA-Ac) and poly(methyl vinyl ether-alt-maleic monoethyl ester) (PMVE/MA-Es) as nanofibers [10,11]. In addition, these polymers have shown utility as matrix elements, allowing the combination with other materials to generate novel mixtures of chemical properties in the final nanostructures [11][12][13], such as with homemade fluorescent cationic fluorene-based polyelectrolytes [11,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics

et al. 2020

View full text Add to dashboard Cite

Recent advances in the field of nanotechnology such as nanoencapsulation offer new biomedical applications, potentially increasing the scope and efficacy of therapeutic drug delivery. In addition, the discovery and development of novel biocompatible polymers increases the versatility of these encapsulating nanostructures, enabling chemical properties of the cargo and vehicle to be adapted to specific physiological requirements. Here, we evaluate the capacity of various polymeric nanostructures to encapsulate various antibiotics of different classes, with differing chemical structure. Polymers were sourced from two separate derivatives of poly(methyl vinyl ether-alt-maleic anhydride) (PMVE/MA): an acid (PMVE/MA-Ac) and a monoethyl ester (PMVE/MA-Es). Nanoencapsulation of antibiotics was attempted through electrospinning, and nanoparticle synthesis through solvent displacement, for both polymers. Solvent incompatibilities prevented the nanoencapsulation of amikacin, neomycin and ciprofloxacin in PMVE/MA-Es nanofibers. However, all compounds were successfully loaded into PMVE/MA-Es nanoparticles. Encapsulation efficiencies in nanofibers reached approximately 100% in all compatible systems; however, efficiencies varied substantially in nanoparticles systems, depending on the tested compound (14%–69%). Finally, it was confirmed that both these encapsulation processes did not alter the antimicrobial activity of any tested antibiotic against Staphylococcus aureus and Escherichia coli, supporting the viability of these approaches for nanoscale delivery of antibiotics.

show abstract

Section: Introductionmentioning

confidence: 99%

Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Recently, Lucio et al. used the nanoparticles of CD-PVM/MA to enhance the oral administration of the anti hyperglycemic agent “glibenclamide”. , The drug-loaded nanoparticles are tested for their hypolipidemic effect in a C. elegans model. Similarly, Demirel et al reported the use of rosuvastatin calcium incorporated CD-PVM/MA nanoparticles to enhance the poor oral bioavailability of rosuvastatin calcium .…”

Section: Classificationmentioning

confidence: 99%

Polyanhydride Chemistry

Reddy

Domb

2022

Biomacromolecules

View full text Add to dashboard Cite

Polyanhydrides (PAs) are a class of synthetic biodegradable polymers employed as controlled drug delivery vehicles. They can be synthesized and scaled up from low-cost starting materials. The structure of PAs can be manipulated synthetically to meet desirable characteristics. PAs are biocompatible, biodegradable, and generate nontoxic metabolites upon degradation, which are easily eliminated from the body. The rate of water penetrating into the polyanhydride (PA) matrix is slower than the anhydride bond cleavage. This phenomenon sets PAs as "surface-eroding drug delivery carriers." Consequently, a variety of PA-based drug delivery carriers in the form of solid implants, pasty injectable formulations, microspheres, nanoparticles, etc. have been developed for the sustained release of small molecule drugs, and vaccines, peptide drugs, and nucleic acid-based active agents. The rate of drug delivery is often controlled by the polymer erosion rate, which is influenced by the polymer structure and composition, crystallinity, hydrophobicity, pH of the release medium, device size, configuration, etc. Owing to the above-mentioned interesting physicochemical and mechanical properties of PAs, the present review focuses on the advancements made in the domain of synthetic biodegradable biomedical PAs for therapeutic delivery applications. Various classes of PAs, their structures, their unique characteristics, their physicochemical and mechanical properties, and factors influencing surface erosion are discussed in detail. The review also summarizes various methods involved in the synthesis of PAs and their utility in the biomedical domain as drug, vaccine, and peptide delivery carriers in different formulations are reviewed.

show abstract

Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers

Arrúa

Hartwig

et al. 2021

Pharm Res

View full text Add to dashboard Cite

Coencapsulation of cyclodextrins into poly(anhydride) nanoparticles to improve the oral administration of glibenclamide. A screening on C. elegans

Cited by 8 publications

References 35 publications

Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics

Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics

Polyanhydride Chemistry

Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers

Contact Info

Product

Resources

About