Coeliac disease in children of short stature without gastrointestinal symptoms

Stenhammar, Lars; Fällström, S. P.; Jansson, Gunnar; Jansson, Ulf; Lindberg, Tor

doi:10.1007/bf00446061

Cited by 44 publications

(31 citation statements)

References 15 publications

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“…Previous studies on children with growth failure but without gastrointestinal symptoms have shown a variable incidence of celiac disease (0 to 59.0%) depending on the region where the study was performed (18)(19)(20)(21)(22)(23)(24)(25). All patients with a diagnosis of celiac disease showed an improvement in growth velocity after the introduction of a gluten-free diet, indicating that this parameter would be useful to confirm the correct diagnosis, as also reported by others (19,23,26).…”

Section: Discussionsupporting

confidence: 64%

Prevalence of celiac disease in Brazilian children of short stature

Queiroz

Nery

Cançado

et al. 2004

Braz J Med Biol Res

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The aim of the present study was to determine the prevalence of celiac disease in children of short stature and to assess whether some of the routine laboratory examinations performed to determine the cause of short stature could suggest the presence of celiac disease. A total of 106 children of short stature and no gastrointestinal symptoms were studied. An extensive endocrine work-up had been negative for all of them and an additional investigation was performed by measuring the concentration of antiendomysial antibody. Patients who were positive for antiendomysial antibody (≥1:10) or who exhibited IgA deficiency (less than 5 mg/dl) were referred for an endoscopic intestinal biopsy.

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Section: Discussionsupporting

confidence: 64%

Prevalence of celiac disease in Brazilian children of short stature

Queiroz

Nery

Cançado

et al. 2004

Braz J Med Biol Res

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“…Older children may present with recurrent abdominal pain or constipation. In teen-agers the symptoms are often more subtle with anaemia (Mody et al, 2003), late puberty or short stature (Stenhammar et al, 1986). Some cases of childhood CD may present with an acute onset of diarrhoea, dehydration and severely affected general condition, so called celiac crisis (Mones et al, 2007).…”

Section: Symptoms Signs and Complicationsmentioning

confidence: 99%

Gut Microflora Associated Characteristics in Children with Celiac Disease

Tjellström

Stenhammar

Högberg

et al. 2005

Am J Gastroenterology

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120

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All previously published papers were reproduced with permission from the publisher. ABSTRACT AimThe over-arching aim of this thesis was to study some metabolic functions of the gut microflora in children with known or screening detected celiac disease (CD) and their first-degree relatives. Materials Study I. A number of 36 untreated CD children, 47 after at least 3 months on glutenfree diet (GFD) and 42 healthy controls (HC). Study II. A number of 76 first-degree relatives to CD children and 93 healthy controls (HC). Study III. A number of 17 screening detected CD children were included to be compared with the untreated children and controls from study I; with exchange of one child in the untreated group, due to low age. Study IV. A comparative study regarding correlation between iso-forms of short chain fatty acids (SCFAs) in humans as well as in animals. Methods Faecal short chain fatty acids were measured in all four studies. Additionally faecal tryptic activity (FTA) was measured in study II. Major findingsAll groups of CD children demonstrated a similar SCFAs profile, i.e. significantly more total SCFAs and acetic acid and a strong tendency to more iso-butyric and iso-valeric acids compared with HC. The first-degree relatives demonstrated another SCFAs profile, i.e. significantly less total SCFAs and acetic acid and significantly more FTA than HC. Conclusions and future outlookBased upon the strong similarities between all groups of CD children we are allowing ourselves hypothesising that CD children have a "celiacogenic" flora compared with healthy controls. In a similar way it can be said that the first-degree relatives are harbouring a "celiacprotective" microflora. Our findings open up for challenging new diagnostic, therapeutic and prognostic possibilities.

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“…Coeliac disease (CD) is a permanent, genetically determined intolerance to gluten that results in entheropathy and frequent malabsorption in children that may impair final statural growth [4,7,8,27,31,32,43,46]. In fact, after starting a gluten-free diet (GFD), a significant increase in height and weight velocity has been evidenced [5,7,11,13,21,22,30], with weight reaching full catch-up growth in the first year of GFD and height reaching the expected centile after about 2 years [1,42,45].…”

Section: Introductionmentioning

confidence: 98%