Growth hormone impaired secretion and antipituitary antibodies in patients with coeliac disease and poor catch-up growth after a long gluten-free diet period: a causal association?

Iughetti, Lorenzo; Bellis, Annamaria De; Predieri, Barbara; Bizzarro, Antonio; Simone, M. De; Balli, Fiorella; Bellastella, Antonio; Bernasconi, Sergio

doi:10.1007/s00431-006-0182-4

Cited by 35 publications

(23 citation statements)

References 47 publications

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“…We characterized APA in adults and prepubertal children with idiopathic GHD [70][71][72], in children with coeliac disease with a lack of catch-up growth after a gluten-free diet [73] and, recently, in male adults with idiopathic hypogonadotropic hypogonadism [74]. APA against somatotrophs or gonadotrophs, when present at high titres, may be considered a good diagnostic marker of autoimmune forms of GHD and gonadotropin deficiency respectively.…”

Section: Role Of Apa In Lyhmentioning

confidence: 98%

Immunological and clinical aspects of lymphocytic hypophysitis

et al. 2008

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LYH (lymphocytic hypophysitis) is an autoimmune disease of the pituitary gland which can present with varying degrees of pituitary hormonal impairment and/or with symptoms related to pituitary enlargement. In this review, we provide an overview of the epidemiology, diagnosis, pathogenesis, treatment, and the role of organ-specific and antipituitary antibodies as potential markers of LYH. In addition, although the mechanisms underlying LYH are not completely understood, the role of prolactin, which plays an important part in maintaining immune system homoeostasis and is increased in the disease, is considered.

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Section: Role Of Apa In Lyhmentioning

confidence: 98%

Immunological and clinical aspects of lymphocytic hypophysitis

et al. 2008

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“…As in previous studies, other factors such as degree of mucosal damage, symptoms and gender do not have any impact on weight and height gain [11]. Additionally, it was shown that autoimmune hypophysitis may be responsible for the poor catch-up growth after gluten-free diet [12].…”

Section: Discussionmentioning

confidence: 91%

Long-Term Effect of Gluten-Free Diet on Growth Velocity in Turkish Children with Celiac Disease

et al. 2008

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We sought to analyze the long-term growth in children with celiac disease (CD) as well as the association of height and weight SD score at the end of 4 years with the demographic and clinical presentation at initial admission. Thirty-four children with CD were enrolled in the study and followed for at least 4 years. Patients were divided into three groups (Group 1: patients 10 years, at the time of diagnosis). Patients' charts were reviewed for demographic and clinical features at initial admission. Anthropometric measurements at initial admission, at 6th months, and 1st, 2nd, 3rd, and 4th years were recorded. Gluten-free diet led to rapid increase in weight SD and height SD score in patients

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“…22 Other studies emphasize on antipituitary autoantibodies (APA) as a case of autoimmune hypophysitis in the somatotroph cells. 24 …”

Section: Discussionmentioning

confidence: 99%

Adult Celiac Disease: Patients Are Shorter Compared with Their Peers in the General Population

Esmaeilzadeh¹,

Ganji²,

Goshayeshi³

et al. 2016

Middle East J Dig Dis

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BACKGROUNDDelay in diagnosis of celiac disease (CD) occurs frequently, although its consequences are mostly not known. One of the presented symptoms in pediatric patients with CD is the short stature. However, far too little attention has been paid to physical features including height of adult patients with CD. This study was undertaken to evaluate whether patients suffering from CD are shorter in comparison with the general population without CD. As well, we evaluated probable correlations between demographic and physical features, main complains, serum anti tTG level, and intestinal pathology damage between short (lower quartile) versus tall stature (upper quartile) patients with CD.METHODSThis was a retrospective cross-sectional study on 219 adult patients diagnosed as having CD in the Celiac Disease Center, between June 2008 and June 2014 in Mashhad, Iran. The exclusion criteria were ages less than 18 and more than 60 years. Height was compared with a group of 657 age- and sex matched control cases from the healthy population. The probable influencing factors on height such as intestinal pathology, serum level of anti-tissue transglutaminase(anti-tTG), serum vitamin D, and hemoglobin level at the time of diagnosis were assessed and were compared in short (lower quartile) versus tall stature (upper quartile) patients with CD.RESULTS Both male (n=65) and female (n=154) patients with CD were shorter than their counterpart in the general population (males: 168.5±8.6 to 171.3±7.2cm, p <0.01 and females: 154.8±10.58 to 157.8±7.2 cm, p <0.01). Spearman linear correlation showed height in patient with CD was correlated with serum hemoglobin (p <0.001, r=0.285) and bone mineral density (p<0.001) and not with serum vitamin D levels (p =0.024, r=0.237), but was not correlated with anti-tTG serum levels (p=0.97). CD patients with upper and lower quartile of height in men and women had no significant difference in the anti-tTG level and degree of duodenal pathology(Marsh grade). Anemia as main complaint was more prevalent in shorter versus taller men.CONCLUSIONAdults with CD are shorter compared with healthy adults. There is a direct correlation between height and anemia and bone mineral density. This finding highlights the importance of early detection and treatment of CD.

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Growth hormone impaired secretion and antipituitary antibodies in patients with coeliac disease and poor catch-up growth after a long gluten-free diet period: a causal association?

Abstract: In our study, the presence of APA in CD children without catch-up growth after GFD seems to be able to identify an autoimmune form of hypophysitis involving the somatotrophs cells.

Cited by 35 publications

References 47 publications

Immunological and clinical aspects of lymphocytic hypophysitis

Immunological and clinical aspects of lymphocytic hypophysitis

Long-Term Effect of Gluten-Free Diet on Growth Velocity in Turkish Children with Celiac Disease

Adult Celiac Disease: Patients Are Shorter Compared with Their Peers in the General Population

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