Coeliac disease, gluten-free diet, and malignancy.

Holmes, Geoffrey; Stokes, P. L.; Sorahan, Tom; Prior, P; Waterhouse, J. A. H.; Cooke, W. T.

doi:10.1136/gut.17.8.612

Cited by 238 publications

(104 citation statements)

References 29 publications

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“…We confirmed previous reports of a strong association with ETTL and of NHL located in the small intestine. 33,34 In addition, we observed a marked association with anaplastic large cell lymphoma, which has not been described previously but is consistent with prior observations of nonintestinal T-cell NHL in celiac disease. 35 Because only 1 of 6 cases of anaplastic large cell lymphoma was situated in the small intestine, misdiagnosis of ETTL with numerous CD30 positive cells is an improbable explanation for the association.…”

Section: Autoimmune Disorders and Lymphoma Subtypes 4035supporting

confidence: 79%

Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium

Smedby

Vajdic

Falster

et al. 2008

Blood

508

223

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Some autoimmune disorders are increasingly recognized as risk factors for nonHodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of selfreported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (

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Section: Autoimmune Disorders and Lymphoma Subtypes 4035supporting

confidence: 79%

Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium

Smedby

Vajdic

Falster

et al. 2008

Blood

508

223

View full text Add to dashboard Cite

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“…In addition, they had considerably more statistical precision for their estimate but included only hospitalized cases of coeliac disease. Other studies finding a higher level of risk are in general older 3,4 (and might therefore be describing a more symptomatic group of patients), but have also in many cases not censored early malignancies and may therefore be susceptible to ascertainment bias. The absolute number of lymphomas occurring in patients with coeliac disease is small.…”

Section: Discussionmentioning

confidence: 99%

“…This association was first described in the early 1960s 1 and subsequently confirmed [2][3][4] but as yet no consistent picture of its magnitude has emerged. Early studies indicated a relative risk for lymphoma of the order of 50-100 3,5,6 but were in general from tertiary referral centres with an interest in coeliac disease and almost certainly included patients with malignancy present at the time of diagnosis of coeliac disease.…”

Section: Introductionmentioning

confidence: 99%

Risk of malignancy in diagnosed coeliac disease: a 24‐year prospective, population‐based, cohort study

Card

West

Holmes

2004

Aliment Pharmacol Ther

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SUMMARYBackground: There is recent evidence from studies of hospitalized and of undiagnosed patients that the risk of lymphoma for people with coeliac disease may be lower than previously thought. In addition, there have been no precise estimates of small bowel lymphoma risk due to a lack of population data. Aim: To examine these and other malignant risks in a cohort of patients more typical of those seen in routine clinical practice. Methods: A prospective cohort study of incident malignancy rates in patients with coeliac disease in southern Derbyshire compared with general population figures.

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“…2 The silent group includes those with subtle, atypical presentations and those presenting with complications of coeliac disease, as well as truly asymptomatic people picked up through screening high-risk groups. Most cases remain undiagnosed and potentially are exposed to the risk of longterm complications, which may include the development of malignancy, 3 particularly ''enteropathy-associated T cell lymphoma''. 4 In addition, patients with coeliac disease have an increased rate of autoimmune disorder, including type 1 diabetes, thyroid diseases, autoimmune liver disease, autoimmune Addison's disease and neurological problems.…”

mentioning

confidence: 99%

Coeliac disease and primary hyperparathyroidism: an association?

Maida

Praveen

Crimmins

et al. 2006

Postgraduate Medical Journal

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Primary hyperparathyroidism may present with non-specific symptoms, and this may be one reason why patients with coeliac disease fail to improve despite compliance with a gluten-free diet. Seven case reports of primary hyperparathyroidism due to sporadic adenoma occurring in a series of 310 patients with coeliac disease are presented, highlighting the importance of looking for this condition in this population group. A prevalence of primary hyperparathyroidism of 2.3% in this series suggests a significant association between hyperparathyroidism and coeliac disease; most studies have indicated a prevalence of 3 in 1000 in the general population, although one study found that it may be as high as 21 in 1000 in women aged 55–75 years. The average age of patients in our series was 59 years and all but one were women. Further studies are needed to establish a possible association between primary hyperparathyroidism and coeliac disease.

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Coeliac disease, gluten-free diet, and malignancy.

Cited by 238 publications

References 29 publications

Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium

Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium

Risk of malignancy in diagnosed coeliac disease: a 24‐year prospective, population‐based, cohort study

Coeliac disease and primary hyperparathyroidism: an association?

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