Coeliac disease and collagenous colitis

O’Mahony, Siobhain M.; Nawroz, Ibrahim; Ferguson, Amy

doi:10.1136/pgmj.66.773.238

Cited by 36 publications

(17 citation statements)

References 9 publications

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“…A close association between lymphocytic and collagenous colitis and celiac sprue has been seen in some patients (25)(26)(27)(28)(29)(30). It is now recognized that the intraepithelial lymphocytes may have a role in the putative immunopathology of celiac sprue (31).…”

Section: Discussionmentioning

confidence: 99%

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Padmanabhan

Callas

et al. 2003

Modern Pathology

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Biopsy specimens from the terminal ileum of 32 patients with the histopathological diagnosis of lymphocytic colitis or collagenous colitis and 11 control individuals were evaluated for the presence or absence of ileal mucosal abnormalities and for the number of intraepithelial lymphocytes, assessed by immunohistochemical stains for the pan T-cell marker, CD3. We found that the mean CD3 counts in patients with lymphocytic/collagenous colitis were significantly higher than those in the control group. Seven of 14 patients with collagenous colitis and 14 of 18 patients with lymphocytic colitis revealed an increase in intraepithelial T lymphocytes when compared with the control group (P ‫؍‬ .001). Other notable changes included ileal villous atrophy in one case of lymphocytic colitis and in three cases of collagenous colitis and epithelial damage with thickened subepithelial collagen in two cases of collagenous colitis.

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Section: Discussionmentioning

confidence: 99%

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Padmanabhan

Callas

et al. 2003

Modern Pathology

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“…Celiac disease occurring in cases of both CC and LC has been described in the literature (3)(4)(5)(6). Two of these studies looked for celiac disease in patients diagnosed with CC (3,6).…”

Section: Figure 1) Titres Of Immunoglobulin a (Iga) Tissue Transglutamentioning

confidence: 99%

Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis

Gillett

Freeman

2000

Canadian Journal of Gastroenterology and Hepatology

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Both collagenous and lymphocytic colitis have been described in patients with celiac disease, suggesting an association between the conditions. Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advancement being the description of tissue transglutaminase as the major antigen for endomysium antibody. A quantitative ELISA was used to measure titres of immunoglobulin A (IgA) antibody to tissue transglutaminase (tTG) along with an immunofluorescent technique for IgA endomysium antibody (EmA) in 15 patients with lymphocytic colitis and eight with collagenous colitis to determine whether celiac disease latency could be detected. One patient with lymphocytic colitis demonstrated both elevated titres of tTG antibody and positive EmA, and small bowel biopsy confirmed celiac disease. One patient with collagenous colitis had a slightly elevated titre of tTG antibody with a negative EmA, and results of a small bowel biopsy were normal. Three other patients with lymphocytic colitis were already treated for previously diagnosed celiac disease. The prevalence of celiac disease occurring in lymphocytic colitis was found to be 27%, but no cases of celiac disease in association with collagenous colitis were found.

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“…In our retrospective study of 163 patients (Table I), 59% of those who tolerated sulphasalazine benefited from it (7). The 5-ASA preparations mesalazine and olsalazine have been tried earlier in small materials and case reports with various results (53,79,101,113,114,118). In our study they had effect in 50% and 40%, respectively (7).…”

Section: Treatmentmentioning

confidence: 98%

“…The three commonest are rheumatoid arthritis, thyroid disorders, and coeliac disease (7,78). Coeliac disease in collagenous colitis has drawn the attention of many authors (58,(99)(100)(101), as the pathogenetic mechanisms could be similar; the inflammatory process in collagenous colitis might, as in coeliac disease, be an immunologic response to a luminal agent. A common aetiology seems unlikely, however (39,100,102).…”

Section: Clinical Featuresmentioning

confidence: 99%

A Review of Collagenous Colitis

Bohr

1998

Scandinavian Journal of Gastroenterology

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Coeliac disease and collagenous colitis

Cited by 36 publications

References 9 publications

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis

A Review of Collagenous Colitis

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