A Review of Collagenous Colitis

Bohr, Johan

doi:10.1080/00365529850166121

Cited by 57 publications

(47 citation statements)

References 74 publications

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“…Most studies have shown that this collagenous layer is thicker in the distal colon than in the proximal regions [3,[5][6][7]11] . Research has also revealed that patients with collagen deposition of at least 15-µm in thickness in more than 30% of multiple colon biopsies eventually develop the clinical syndrome [1,3] .…”

Section: Discussionmentioning

confidence: 99%

“…Thus, sampling error is a probable cause of under diagnosis in collagenous colitis. Some investigators consider thickness >10 µm to be diagnostic, whereas others use >15 µm, and still others >30 µm [3,[5][6][7]11] . The SEBM thickness documented in cases of collagenous colitis in the English literature range from 11.5 to 60 µm [6,[13][14][15][16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

“…The main histopathological criteria for collagenous colitis include the characteristic findings of a thick, continuous, hypocellular, eosinophilic, linear fibrous band beneath the surface epithelium, as well as intraepithelial lymphocytosis, epithelial vacuolization, and desquamation [1,3,[5][6][7]11] . One of the difficulties in diagnosing collagenous colitis is that different sources cite different SEBM thickness as one of the main criteria for diagnosis [9] .…”

Section: Discussionmentioning

confidence: 99%

“…In healthy adults, the subepithelial basement membrane (SEBM) of the colon consists of collagen types I and IV, laminin, and fibronectin. The thickness of this layer varies from 0 to 7 µm [3,[5][6][7]12] , and is slightly greater in the settings of hyperplastic polyps, colonic diverticulum, and congenital megacolon [3,6] . In this study, we investigated SEBM thickness in biopsies from five different colonic sites in patients from the southern Anatolia region of Turkey.…”

Section: Introductionmentioning

confidence: 99%

“…Lindstrom introduced the term "collagenous colitis" to describe a colon biopsy that showed hyalinized substance, known as a collagen band, between the transition zone of the subluminal basement membrane and the lamina propria [1][2][3][4][5][6][7][8] . The English literature contains approximately 200 reports of this condition [7] .…”

Section: Introductionmentioning

confidence: 99%

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Subepithelial basement membrane thickness in patients with normal colonic mucosal appearance in colonoscopy: Results from southern Turkey

Kayaselçuk¹,

Serin²,

Gümürdülü³

et al. 2004

WJG

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AIM:Our aims were to determine the normal limits of subepithelial basement membrane (SEBM) thickness in order to more accurately diagnose collagenous colitis in the population from southern Turkey and to investigate into links between SEBM thickness and age, and sex. METHODS:The study included 100 patients (mean age 50.0±13.3 years; male, 34; female, 66) with miscellaneous gastrointestinal symptoms, and normal colonic mucosal appearance in colonoscopic evaluation. Biopsies were taken from five different regions of the colon. SEBM was measured with a calibrated eyepiece on specimens prepared with specific stains for collagen. Intensity of inflammatory cells was graded semiquantitatively. Differences in SEBM thickness among the different colon regions, and relationships between SEBM thickness and age, sex, and density of inflammatory cells were statistically evaluated. RESULTS:The cecum and rectum showed the largest amounts of infiltrate. None of the specimens showed histologic findings of collagenous colitis. The SEBM thicknesses measured for each case ranged from 3-20 µm. The biggest thickness was observed in rectal mucosa (median value: 10 µm). Cecum and ascending colon showed similar SEBM thickness (median value: 5 µm). SEBM thickness was not correlated with patient age or sex, but was positively correlated with the intensity of inflammatory cells in each colon segment. CONCLUSION:In this patient group from southern Turkey, SEBM was thickest in the rectum. Our results indicate that, in this population, SEBM thickness is not correlated with age or sex, but is positively correlated with severity of inflammation. The findings also support the concept that measuring SEBM thickness at one segment in the colon is inadequate and may be misleading.Kayaselcuk F, Serin E, Gumurdulu Y, Ozer B, Tuncer I, Boyacioglu S. Subepithelial basement membrane thickness in patients with normal colonic mucosal appearance in colonoscopy: Results from southern Turkey.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Subepithelial basement membrane thickness in patients with normal colonic mucosal appearance in colonoscopy: Results from southern Turkey

Kayaselçuk¹,

Serin²,

Gümürdülü³

et al. 2004

WJG

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Microscopic Colitis

Hoentjen

Mulder

Bouma

2012

Textbook of Clinical Gastroenterology and Hepatology

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Short- and long- term follow-up of treatment for lymphocytic and collagenous colitis

et al. 2007

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Summary:Collagenous colitis and lymphocytic colitis cause chronic watery diarrhea. Multiple therapies have been found to improve symptoms but there have been few long-term followup studies. Our goal was to obtain long-term clinical follow-up on a cohort of patients with independently confirmed typical histopathologic changes. Pathology slides from 32 cases of collagenous or lymphocytic colitis patients from 1988-1992 were independently reviewed. Twenty-five cases were confirmed by both groups of pathologist as collagenous or lymphocytic colitis. For these 25 patients, charts were reviewed and telephone follow-up interviews were performed in 1992 and 1995. Seven of 32 (22%) of the original cases were not confirmed on independent pathologic interpretation. A 15.8% discordance rate was found between the different groups of pathologists. Patient demographics were similar to previously published reports except one-half of our patients had diarrhea of only 6 months or less. Eighty-one percent of patients receiving 5-ASA agents reported improvement as well as 100% of those receiving prednisone. At 23 month follow-up 86% of patients reported improvement in diarrhea and only 32% required routine medications. At 47 month follow-up all patients reported improved diarrhea and only 29% required routine medications. Collagenous and lymphocytic colitis can sometimes be identified in patients with relatively brief duration diarrhea. Clinical parameters and response to therapy are similar for collagenous or lymphocytic colitis. Most patients with lymphocytic and collagenous colitis improve with therapy such as 5-ASA preparations or steroids. Over a follow-up period of several years, most patients have improvement in diarrhea and generally do not require maintenance medications. Independent pathologic confirmation of the diagnosis should be obtained in patients not responding to therapy.

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A Review of Collagenous Colitis

Cited by 57 publications

References 74 publications

Subepithelial basement membrane thickness in patients with normal colonic mucosal appearance in colonoscopy: Results from southern Turkey

Subepithelial basement membrane thickness in patients with normal colonic mucosal appearance in colonoscopy: Results from southern Turkey

Microscopic Colitis

Short- and long- term follow-up of treatment for lymphocytic and collagenous colitis

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