In our present investigation, we extend the idea of q-symmetric derivative operators to multivalent functions and then define a new subclass of multivalent q-starlike functions. For this newly defined function class, we discuss some useful properties of multivalent functions, such as the Hankel determinant, symmetric Toeplitz matrices, the Fekete–Szego problem, and upper bounds of the functional ap+1−μap+12 and investigate some new lemmas for our main results. In addition, we consider the q-Bernardi integral operator along with q-symmetric calculus and discuss some applications of our main results.