2020
DOI: 10.1021/acsinfecdis.0c00321
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Codelivery of Sustainable Antimicrobial Agents and Platelet-Derived Growth Factor via Biodegradable Nanofibers for Repair of Diabetic Infectious Wounds

Abstract: More than half of diabetic wounds demonstrate clinical signs of infection at presentation and lead to poor outcomes. This work develops coaxial sheath-core nanofibrous poly­(lactide-co-glycolide) (PLGA) scaffolds that are loaded with bioactive antibiotics and platelet-derived growth factor (PDGF) for the repair of diabetic infectious wounds. PDGF and PLGA/antibiotic solutions were pumped, respectively, into two independent capillary tubings for coaxial electrospinning to prepare biodegradable sheath-core nanof… Show more

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Cited by 44 publications
(32 citation statements)
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“… Biodegradable sheath-core nanofibers. [ 60 ] EGF OHA and SCS hydrogels Promotion of fibroblast proliferation and tissue internal structure integrity, as well as the deposition of collagen and myofibrils. pH-responsive hydrogel.…”
Section: Substances Applied In Diabetic Wound Healingmentioning
confidence: 99%
“… Biodegradable sheath-core nanofibers. [ 60 ] EGF OHA and SCS hydrogels Promotion of fibroblast proliferation and tissue internal structure integrity, as well as the deposition of collagen and myofibrils. pH-responsive hydrogel.…”
Section: Substances Applied In Diabetic Wound Healingmentioning
confidence: 99%
“…In this regard, preparation of wound dressing with high antibacterial property is needed. Delivery of antimicrobial agents and a platelet-derived growth factor via biodegradable nanofibers for repair of diabetic infectious wounds was investigated [15]. e use of herbal extracts with several therapeutic effects and few side effects is highly suggested compared to chemical and synthetic drugs [16].…”
Section: Introductionmentioning
confidence: 99%
“…For the sheath-core nanofibrous layer, PLGA (896 mg) and lidocaine (224 mg) were dissolved in 4 mL of HFIP as the sheath material, while the core mixture consisted of 1 mL of CTGF (20 μg) mixed with 1 mL of phosphate-buffered saline (PBS). A dedicated co-axial electrospinning apparatus that concurrently conveys two mixtures to a collection sheet was employed to spin the nanofibers [ 17 ]. The sheath-layer PLGA/lidocaine and the core CTGF mixtures were charged into two separate feeding syringes.…”
Section: Methodsmentioning
confidence: 99%