Codelivery of Phytochemicals with Conventional Anticancer Drugs in Form of Nanocarriers

Abstract

Anticancer drugs in monotherapy are ineffective to treat various kinds of cancer due to the heterogeneous nature of cancer. Moreover, available anticancer drugs possessed various hurdles, such as drug resistance, insensitivity of cancer cells to drugs, adverse effects and patient inconveniences. Hence, plant-based phytochemicals could be a better substitute for conventional chemotherapy for treatment of cancer due to various properties: lesser adverse effects, action via multiple pathways, economical, etc. Various preclinical studies have demonstrated that a combination of phytochemicals with conventional anticancer drugs is more efficacious than phytochemicals individually to treat cancer because plant-derived compounds have lower anticancer efficacy than conventional anticancer drugs. Moreover, phytochemicals suffer from poor aqueous solubility and reduced bioavailability, which must be resolved for efficacious treatment of cancer. Therefore, nanotechnology-based novel carriers are employed for codelivery of phytochemicals and conventional anticancer drugs for better treatment of cancer. These novel carriers include nanoemulsion, nanosuspension, nanostructured lipid carriers, solid lipid nanoparticles, polymeric nanoparticles, polymeric micelles, dendrimers, metallic nanoparticles, carbon nanotubes that provide various benefits of improved solubility, reduced adverse effects, higher efficacy, reduced dose, improved dosing frequency, reduced drug resistance, improved bioavailability and higher patient compliance. This review summarizes various phytochemicals employed in treatment of cancer, combination therapy of phytochemicals with anticancer drugs and various nanotechnology-based carriers to deliver the combination therapy in treatment of cancer.

Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies

“…These are made up of either solid lipids or a combination of lipids and surfactants [64]. They may also contain an aqueous phase, surface modifiers, co-surfactants, stealthing agents, and cryoprotective chemicals [65]. A hydrophobic medication, or combination of hydrophobic drugs, is confined within the solid lipid matrix of SLNs, providing physical stability by shielding the molecule from chemical deterioration.…”

“…They have certain structural and chemical characteristics such size (less than 100 nm), shape, and molecular weight. Dendrimers have the potential to prolong drug release, increase the solubility of hydrophobic compounds, and improve the permeability of nanoconjugates across a variety of biological barriers [65]. Although several dendrimers have been applied for drug delivery in various diseases, polyamidoamine (PAMAM) and polypropylene imine (PPI) are extensively used owing to their hydrophilic nature, biocompatibility, and non-immunogenicity [92].…”

Integrating natural compounds and nanoparticle‐based drug delivery systems: A novel strategy for enhanced efficacy and selectivity in cancer therapy

“…Traditional cancer treatments, including chemotherapy, radiation therapy, and surgery have several drawbacks, such as systemic toxicity, poor pharmacokinetics, and drug resistance. Therefore, there is a rising interest in the conception of innovative cancer treatments that are more efficient, less harmful, and better tolerated 2,3 . Utilizing natural chemicals, which are chemical compounds produced from plants or other naturally occurring sources, is one viable strategy 4 …”

“…Therefore, there is a rising interest in the conception of innovative cancer treatments that are more efficient, less harmful, and better tolerated. 2,3 Utilizing natural chemicals, which are chemical compounds produced from plants or other naturally occurring sources, is one viable strategy. 4 Natural compounds are bioactive molecules derived from various sources, including plants, fungi, and marine organisms.…”

Amomum subulatum Fruit Extract Mediated Green Synthesis of Silver and Copper Oxide Nanoparticles: Synthesis, Characterization, Antibacterial and Anticancer Activities

“…Similarly, cancer is the second leading cause of mortality across the globe, accounting for 7.6 million deaths, with the number expected to climb to almost 13.1 million by 2030 [3,4]. Surgery, radiation, chemotherapy, and a combination of these treatments are the mainstays of traditional treatment, and chemotherapeutic treatment is widely accepted for the treatment of cancer.…”