Cocooning

Grizas, Alexandra P.; Camenga, Deepa R.; Vázquez, Marietta

doi:10.1097/mop.0b013e32834e8fe9

Cited by 42 publications

(7 citation statements)

References 32 publications

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“…Other factors can prevent influenza in infants such as the effect of breast-feeding [45] and immunization of all the infant's close contacts, also known as cocooning [46]. To avoid confounding and enable comparison, groups should be set by randomization.…”

Section: Discussionmentioning

confidence: 99%

Influenza Vaccination in Pregnant Women: A Systematic Review

Galvão

Zimmermann

Lopes³

et al. 2013

ISRN Preventive Medicine

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Objective. To assess the effects of the inactivated influenza virus vaccine on influenza outcomes in pregnant women and their infants. Methods. We performed a systematic review of the literature. We searched for randomized controlled trials and cohort studies in the MEDLINE, Embase, and other relevant databases (inception to September 2013). Two researchers selected studies and extracted the data independently. We used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the quality of the evidence. Results. We included eight studies out of 1,967 retrieved records. Influenza vaccination in pregnant women significantly reduced the incidence of influenza-like illness in mothers and their infants when compared with control groups (high-quality evidence) and reduced the incidence of laboratory-confirmed influenza in infants (moderate-quality evidence). No difference was found with regard to influenza-like illness with fever higher than 38°C (moderate-quality evidence) or upper respiratory infection (very-low-quality evidence) in mothers and infants. Conclusions. Maternal vaccination against influenza was shown to prevent influenza-like illness in women and infants; no differences were found for other outcomes. As the quality of evidence was not high overall, further research is needed to increase confidence and could possibly change these estimates.

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Section: Discussionmentioning

confidence: 99%

Influenza Vaccination in Pregnant Women: A Systematic Review

Galvão

Zimmermann

Lopes³

et al. 2013

ISRN Preventive Medicine

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“…For high-risk individuals who are unable to be vaccinated, herd immunity represents a life-saving protection strategy against many infections. An alternative strategy, cocooning, has been employed with limited success for pertussis and influenza ( Grizas et al, 2012 ), where their close/household contacts are vaccinated to prevent transmission.…”

Section: Health Benefits Of Vaccinationmentioning

confidence: 99%

Impact of Vaccines; Health, Economic and Social Perspectives

2020

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In the 20th century, the development, licensing and implementation of vaccines as part of large, systematic immunization programs started to address health inequities that existed globally. However, at the time of writing, access to vaccines that prevent life-threatening infectious diseases remains unequal to all infants, children and adults in the world. This is a problem that many individuals and agencies are working hard to address globally. As clinicians and biomedical scientists we often focus on the health benefits that vaccines provide, in the prevention of ill-health and death from infectious pathogens. Here we discuss the health, economic and social benefits of vaccines that have been identified and studied in recent years, impacting all regions and all age groups. After learning of the emergence of SARS-CoV-2 virus in December 2019, and its potential for global dissemination to cause COVID-19 disease was realized, there was an urgent need to develop vaccines at an unprecedented rate and scale. As we appreciate and quantify the health, economic and social benefits of vaccines and immunization programs to individuals and society, we should endeavor to communicate this to the public and policy makers, for the benefit of endemic, epidemic, and pandemic diseases.

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“…The effectiveness of cocooning as a strategy to achieve lasting control of infections hinges upon several key factors, including healthcare provider advocacy, patient education, the implementation and enforcement of policies, and the development of cost-effective programs. 23 The mother’s status of already being vaccinated against influenza is the main factor that increases the acceptance rate of the cocoon by the household. 24 In our study, we observed that if there are vaccinated individuals in the family, mothers are always one of the vaccinated individuals, which means that mothers are much more motivated about protection of their babies.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of cocoon strategy vaccination on prevention of influenza-like illness in young infants

Oguz,

Senel

2024

Human Vaccines & Immunotherapeutics

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During the initial half-year of their existence, infants cannot receive the influenza vaccine, yet they face the greatest susceptibility to severe influenza complications. In this study, we seek to determine whether influenza vaccination of maternal and household contacts is associated with a reduced risk of influenza-like illness (ILI) and severe acute respiratory infection (SARI) in infants. This work was prospectively conducted during the influenza season. A total of 206 infants were included in this study. The percentage of infants with only the mother vaccinated is 12.6% (n:26), and the percent of infants with all household contacts vaccinated is 16% (n:33). Among the infants with only the mother vaccinated, the effectiveness of influenza vaccine is estimated as 35.3% for ILI and 41.3% for SARI. Among infants with all household contacts vaccinated, the effectiveness is estimated as 48.9% for ILI and 76.9% for SARI. Based on the results of multivariate logistic regression analysis, all-household vaccination is a protective factor against SARI (OR: 0.07 95% CI [0.01–0.56]), household size (OR: 1.75, 95% CI [1.24–2.48]) and presence of secondhand smoke (OR: 2.2, 95% CI [1.12–4.45]) significant risk factors for SARI in infants. The mother alone being vaccinated is not a statistically significant protective factor against ILI (OR: 0.46, 95% CI [0.19–1.18]) or SARI (OR: 0.3, 95% CI [0.11–1.21]). Along with the obtained results and analysis, this study provides clear evidence that influenza vaccination of all household contacts of infants aged 0–6 months is significantly associated with protecting infants from both ILI and SARI.

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Cocooning

Cited by 42 publications

References 32 publications

Influenza Vaccination in Pregnant Women: A Systematic Review

Influenza Vaccination in Pregnant Women: A Systematic Review

Impact of Vaccines; Health, Economic and Social Perspectives

Effectiveness of cocoon strategy vaccination on prevention of influenza-like illness in young infants

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