Coccidioidomycosis in a Lung Transplant Recipient Acquired From the Donor Graft in France

Brugière, Olivier; Forget, Elisabeth; Biondi, Giuseppina; Métivier, Anne-Cécile; Mal, Hervé; Dauriat, Gaëlle; Faussart, Alexandra; Dupont, B.; Lortholary, Olivier; Dromer, Françoise

doi:10.1097/tp.0b013e3181bc22e1

Cited by 33 publications

(32 citation statements)

References 5 publications

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“…Since then, two cases of disseminated coccidioidomycosis from a single donor were reported in 2003 (102). Another fatal case was reported in 2004 (103), as well as one in France that occurred at nearly 1 year posttransplantation (104). Three other patients developed coccidioidomycosis from one donor within 3 weeks of transplantation (105), and three of five patients who received organs from a single donor developed active infection, two of which disseminated (106).…”

Section: Specific Immune Deficits Associated With Coccidioidomycosismentioning

confidence: 99%

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

et al. 2013

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SUMMARY Coccidioidomycosis is the endemic mycosis caused by the fungal pathogens Coccidioides immitis and C. posadasii . This review is a summary of the recent advances that have been made in the understanding of this pathogen, including its mycology, genetics, and niche in the environment. Updates on the epidemiology of the organism emphasize that it is a continuing, significant problem in areas of endemicity. For a variety of reasons, the number of reported coccidioidal infections has increased dramatically over the past decade. While continual improvements in the fields of organ transplantation and management of autoimmune disorders and patients with HIV have led to dilemmas with concurrent infection with coccidioidomycosis, they have also led to advances in the understanding of the human immune response to infection. There have been some advances in therapeutics with the increased use of newer azoles. Lastly, there is an overview of the ongoing search for a preventative vaccine.

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Section: Specific Immune Deficits Associated With Coccidioidomycosismentioning

confidence: 99%

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

et al. 2013

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“…Coccidioidomycosis occurs in 1.5-8.7% of the transplant recipients in endemic areas, typically in the first posttransplant year (81). Several cases of donor-derived coccidioidomycosis in transplant recipients have been reported (49,(82)(83)(84)(85)(86)(87)(88)(89)(90) (92). Further assessment to define the presence of extrapulmonary infection may be warranted in such instances, with particular attention to the CNS, cutaneous and osteoarticular infections.…”

Section: Coccidioidomycosismentioning

confidence: 99%

Donor-Derived Fungal Infections in Organ Transplant Recipients: Guidelines of the American Society of Transplantation, Infectious Diseases Community of Practice

Singh

Huprikar

Burdette

et al. 2012

American Journal of Transplantation

149

154

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“…The most common sites of dissemination include skin, lymph nodes, bones, and joints; nonetheless, the most feared complication is extension to the central nervous system. Besides acquisition of infection through the respiratory route, there are rare reports of direct inoculation of skin, giving rise to primary cutaneous lesions, or acquisition through transplanted organs (21,102,116).…”

Section: Coccidioidomycosis (I) Epidemiologic and Clinical Situationmentioning

confidence: 99%

Histopathologic Diagnosis of Fungal Infections in the 21st Century

2011

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SUMMARY Fungal infections are becoming more frequent because of expansion of at-risk populations and the use of treatment modalities that permit longer survival of these patients. Because histopathologic examination of tissues detects fungal invasion of tissues and vessels as well as the host reaction to the fungus, it is and will remain an important tool to define the diagnostic significance of positive culture isolates or results from PCR testing. However, there are very few instances where the morphological characteristics of fungi are specific. Therefore, histopathologic diagnosis should be primarily descriptive of the fungus and should include the presence or absence of tissue invasion and the host reaction to the infection. The pathology report should also include a comment stating the most frequent fungi associated with that morphology as well as other possible fungi and parasites that should be considered in the differential diagnosis. Alternate techniques have been used to determine the specific agent present in the histopathologic specimen, including immunohistochemistry, in situ hybridization, and PCR. In addition, techniques such as laser microdissection will be useful to detect the now more frequently recognized dual fungal infections and the local environment in which this phenomenon occurs.

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Coccidioidomycosis in a Lung Transplant Recipient Acquired From the Donor Graft in France

Cited by 33 publications

References 5 publications

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

Donor-Derived Fungal Infections in Organ Transplant Recipients: Guidelines of the American Society of Transplantation, Infectious Diseases Community of Practice

Histopathologic Diagnosis of Fungal Infections in the 21st Century

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