Cocaine and Lidocaine as Topical Urethral Anesthetics

Pliskin, Marc; Kreder, Karl J.; Desmond, Patricia; Dresner, Martin L.

doi:10.1097/00132586-199002000-00019

Cited by 6 publications

(6 citation statements)

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“…In this study, TUSB was found to be superior to intraurethral lidocaine jelly in reducing pain during rigid cystoscopy even when the intraurethral lidocaine jelly volume and dwell time was 30 cc and 30 min, respectively. This superiority is not related to differences in age between the two groups, as it has been shown that older men tolerated rigid cystoscopy more than younger men [15]. The mean age of patients receiving TUSB was statistically similar to the age of men receiving lidocaine jelly (Table 1).…”

Section: Discussionmentioning

confidence: 58%

An assessment of the clinical utility of transperineal urethrosphincteric block (TUSB) in outpatient rigid cystoscopy: a single-blind, randomized study

et al. 2008

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Section: Discussionmentioning

confidence: 58%

An assessment of the clinical utility of transperineal urethrosphincteric block (TUSB) in outpatient rigid cystoscopy: a single-blind, randomized study

et al. 2008

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“…Cocaine (4%) combined with lidocaine jelly (2%) was compared with lidocaine jelly (2%) alone as a urethral anaesthetic by Pliskin et al (1989). Using a scoring scale of 1 (no discomfort) to 10 (severe discomfort) no significant difference was observed between regimens.…”

Section: Clinical Usementioning

confidence: 99%

Clinical Use of Cocaine

Middleton

Kirkpatrick

1993

Drug Safety

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Following the isolation of cocaine from the extract of coca leaves in the late 1700s by Albert Neiman, the local anaesthetic properties of the drug have been evaluated. The anaesthetic effect of cocaine is believed to be the result of reversible blockade of nervous impulse conduction by the prevention of sodium ion movement within the cell membrane. The many undesired effects, however, are the result of adrenergic stimulation by means of prevention of noradrenaline (norepinephrine) uptake. The clinical use of cocaine in the modern era is associated primarily with surgical procedures involving the manipulation of mucous membranes, particularly those of the upper respiratory tract. Recently, based on problems with the potential for illicit use and adverse effects, alternative regimens have been investigated. In some settings these have been superior to cocaine. Further studies comparing various anaesthetic regimens are warranted.

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“…Cocaine was reported as the first topical anesthetic agent for cystoscopy in 1884. [5,6] Historically, a lubricating gel with 2% lidocaine used as an intraurethral anesthetic has been a standard of care in men undergoing rigid cystoscopy; however, with introduction of the flexible cystoscope, the need for intraurethral anesthesia in men has been questioned. [7] The primary objective of this study was to determine whether intraurethral lubricating gel containing 2% lidocaine results in lower average pain scores compared with the plain lubricating gel in men undergoing flexible cystoscopy.…”

Section: Introductionmentioning

confidence: 99%

2% Lidocaine gel or plain lubricating gel: Which one should be used in male flexible cystoscopy?

Akkoç

Kartalmiş²,

Aydın

et al. 2016

Turkish Journal of Urology

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Objective: To investigate and compare the effects on pain of intraurethral 2% lidocaine gel and plain lubricating gel in male patients underwent flexible cystoscopy. Material and methods:The data of 220 male patients who underwent flexible cystoscopy between March 2012 and August 2014 were retrospectively analized. The patients were divided into 2 groups according to using intraurethral gel types. Group I included 120 patients who were underwent flexible cystoscopy with 2% lidocaine gel and Group II was consisted from 100 patients who underwent flexible cystoscopy with plain lubricating gel. The groups were compared according to postprocedure data including pain score, procedure time and age of patients. Results:The mean age of the patients in Group I was 50.02±11.87 years while that in Group II was 52.03±13.37 years (p= 0.492). The mean procedure times were 6.02±0.787 and 6.28±0.689 minutes in Group I and Group II respectively (p= 0.061). Pain perception scores were not statistically different between the groups (Group I: 3.10±0.980, Group II: 3.34±0.789, p= 0.132). Conclusion:Use of intraurethral 2% lidocaine gel has no advantage over plain lubricating gel in regard to pain control during flexible cystoscopy in men.

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Cocaine and Lidocaine as Topical Urethral Anesthetics

Cited by 6 publications

References 0 publications

An assessment of the clinical utility of transperineal urethrosphincteric block (TUSB) in outpatient rigid cystoscopy: a single-blind, randomized study

An assessment of the clinical utility of transperineal urethrosphincteric block (TUSB) in outpatient rigid cystoscopy: a single-blind, randomized study

Clinical Use of Cocaine

2% Lidocaine gel or plain lubricating gel: Which one should be used in male flexible cystoscopy?

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