Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors

Lakatos, Anita; Prinster, Steven C.; Vicentic, Aleksandra; Hall, Randy A.; Kuhar, Michael J.

doi:10.1016/j.neulet.2005.04.072

Cited by 96 publications

(69 citation statements)

References 15 publications

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“…No receptor for CART peptides has yet been identified, but some cellular effects have been observed, such as the induction of c-Fos activity in brain areas that are related to feeding and energy expenditure [159] or the induction of phosphorylation of ERK in AtT20 cells [160] which activates the MAP kinase pathways.…”

Section: Cartmentioning

confidence: 99%

Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

Fernández-Santos¹,

García-Marín²,

Utrilla³

et al. 2012

Thyroid Hormone

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Section: Cartmentioning

confidence: 99%

Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

Fernández-Santos¹,

García-Marín²,

Utrilla³

et al. 2012

Thyroid Hormone

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“…Moreover, the binding of the agonist CART peptide was reduced in the presence of excess GTP analogue, but not in the presence of excess ATP analogue, indicating that the CART receptor being studied in the AtT20 cells was a G protein-coupled receptor. Furthermore, pertussis toxin inhibited CART signaling indicating that the GPCR was coupled with a Gi or a Go protein [9]. More recently, another laboratory found CART receptor binding in differentiated PC12 cells [43].…”

Section: A Search For the Cart Receptormentioning

confidence: 98%

“…After taking a new approach, that is exploring cell lines for CART-induced signaling events, it was found that application of CART55-102 to AtT20 cells resulted in an increase in P-ERK-1 and P-ERK-2 [9]. Shortly thereafter, Vicentic et al [10] identified specific binding in the same cell line under the same conditions ( Figure 2).…”

Section: A Search For the Cart Receptormentioning

confidence: 99%

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CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system

Hubert

Jones

Moffett

et al. 2008

Biochemical Pharmacology

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CART (cocaine-and amphetamine-regulated transcript) peptides are peptidergic neurotransmitters that are widely but specifically distributed throughout the brain, gut and other parts of the body. They are found in many brain regions associated with drug addiction including the nucleus accumbens, ventral tegmental area and ventral pallidum. Injections of CART 55-102 into the nucleus accumbens have no effect on basal locomotor activity. However, an injection of CART just before an i.p. injection of cocaine reduces the locomotor activating effects of cocaine. These and other data suggest that CART in the accumbens blunts the effects of cocaine. A hypothesis is that CART is homeostatic in the accumbens and tends to oppose large increases in dopamine signaling. These actions would therefore be able to regulate the effects of some abused drugs such as the psychostimulants.

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“…Rogge et al proposed in 2008 [159] a signaling mechanism for such potential receptors. Due to the observation that signaling induced by CART can be inhibited by pertussis toxin a G i /o protein coupled mechanism has been suggested but also activation of MEK and ERK ½ has been demonstrated in mouse pituitary cell lines [160]. CART itself is presumed to be involved in reward and reinforcement, feeding, stress and neuroendocrine control [161].…”

Section: Cart and Its Potential Receptormentioning

confidence: 99%

Non-peptide ligands in the characterization of peptide receptors at the interface between neuroendocrine and mental diseases

Pissarek¹,

Disko²

2013

WJNS

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Hypothalamic receptors for neuropeptide Y, melaninconcentrating hormone, melanocortins and orexins/ hypocretins as well as for the downstream signaling corticotrophic factor have been discussed broadly for their influence on food intake and reward but also on several psychiatric disorders. For the development of non-peptide ligands for the in vivo detection of alterations in density and affinity of such G-protein coupled (GPCRs) peptide receptors the requirements to affinity and pharmacokinetics have been shifted to thresholds markedly distict from classical GPCRs to dissociation constants < 0.5 nM, partition coefficients log P < 3.5 and transcellular transport ratios, e.g. for the permeability glycoprotein transporter, below 3. Nevertheless, a multitude of compounds has been reported originally as potential therapeutics in the treatment of obesity among which some are suitable candidates for labeling as PET or SPECT-tracers providing receptor affinities even below 0.1 nM. These could be unique tools not only for better understanding of the mechanism of obesity but also for investigations of extrahypothalamic role of "feeding receptors" at the interface between neuroendocrine and mental diseases.

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Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors

Cited by 96 publications

References 15 publications

Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system

Non-peptide ligands in the characterization of peptide receptors at the interface between neuroendocrine and mental diseases

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