Cobblestone mouth: An exuberant oral presentation of pemphigus vegetans

Mendes‐Bastos, Pedro; Amaro, Cristina; Fernandes, Carolina

doi:10.1016/j.ad.2014.05.004

Cited by 4 publications

(3 citation statements)

References 3 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to de Almeida, the involvement of the vermilion border of the lips is a clinical hallmark of oral involvement. The tongue may also be involved with scrotal or cerebriform‐like changes . Oral involvement as in our case may mimic pyostomatitis vegetans.…”

Section: Discussionmentioning

confidence: 66%

Multiple vegetating plaques on a Cesarean section scar

et al. 2018

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 66%

Multiple vegetating plaques on a Cesarean section scar

et al. 2018

View full text Add to dashboard Cite

“…To compare our patient's antibody profile with autoimmunological findings of previously described patients suffering from PVeg, we reviewed the Anglophone literature from December 1988 to January 2017, considering all available full-text publications providing information on mucous membranes and/or skin involvement and autoantibody levels (at least anti-Dsg1 and/or anti-Dsg3 reactivity; Table 1) [2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34]. …”

Section: Review Of the Literature And Discussionmentioning

confidence: 99%

Atypical Clinical and Serological Manifestation of Pemphigus Vegetans: A Case Report and Review of the Literature

et al. 2017

View full text Add to dashboard Cite

Pemphigus vegetans (PVeg) is a rare variant of pemphigus vulgaris characterized by pustules and/or papillomatous vegetations, preferentially affecting intertriginous and periorificial areas. Exceptional manifestations may be misdiagnosed resulting in delayed diagnosis and treatment. Diagnosis is confirmed by immunofluorescence and detection of anti-desmoglein (Dsg) 3 and/or anti-Dsg1 antibodies. We herein report an unusual manifestation of PVeg. At the time of first presentation, lesions were restricted to the right ring finger’s tip. Although mucous membranes were initially not affected, high levels of anti-Dsg3 antibodies were detected while anti-Dsg1 and anti-desmocollin (Dsc) 1, 2, and 3 antibodies were absent. To compare our immunological findings with previous reports, all accessible Anglophone literature published since December 1988 was evaluated. We identified 52 patients suffering from PVeg, 7 of these showed anti-Dsg3 antibodies without any mucous membrane involvement. Notably, the detection of anti-Dsg1 and anti-Dsg3 antibodies does not necessarily correlate with the involvement of skin and/or mucous membranes. This might be due to more specific and complex antibody constellations in nonclassical or atypical pemphigus.

show abstract

“…Mucosal involvement may not always be seen. Involvement of the vermillion border of the lips is the clinical hallmark of oral involvement [54]. Nail involvement is rarely described [50].…”

Section: Clinical Featuresmentioning

confidence: 99%

Pemphigus: Subtypes, Clinical Features, Diagnosis, and Treatment

Kılıç¹

2018

Autoimmune Bullous Diseases

View full text Add to dashboard Cite

Pemphigus is a group of autoimmune blistering disorders associated with autoantibodies against the keratinocyte cell surface. Pemphigus has three major variants: pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP) which all have further subtypes. The variants of pemphigus are classified depending upon the clinical and histological features, immunofluorescence staining pattern, and autoantibody profile of the disease. The onset and course of pemphigus appear on the basis of interaction between genetic predisposition and various triggering factors. Pemphigus vulgaris is the most commonly seen and representative clinical form of pemphigus. Together with clinical manifestations, the histopathological and immunopathological data support the diagnosis. As though some pemphigus variants, particularly pemphigus vulgaris and paraneoplastic pemphigus, have a mortality risk, early diagnosis is necessary and onset of treatment should be promptly initiated. In this chapter, firstly, classification of pemphigus is described. After then, clinical features, histopathological and immunopathological findings, target antigens, etiopathogenesis and comorbidities of each pemphigus variant are discussed briefly.Keywords: pemphigus, pemphigus variants, clinical manifestations, pathogenesis, histopathology, immunopathology IntroductionPemphigus is a distinct organ-specific autoimmune blistering disorder involving skin and mucous membranes associated with autoantibodies directed against desmosomes-intercellular adhesive molecule complex localized on the keratinocyte cell surface [1][2][3][4].© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Pemphigus has three major variants, which are classified depending on the basis of the clinical, histological features, immunofluorescence staining pattern and autoantibody profile of the disease including pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP), which all have further subtypes. Less frequently seen and newer variants of pemphigus include IgA pemphigus (IGAP) and pemphigus herpetiformis (PH) [1-6].The term "pemphigus" origins from the Greek word "pemphix", which has a meaning of "blister" [1]. It is a chronic potentially life-threating bullous disorder if not treated on time [4,7,8]. The phenotypes of pemphigus represent a complex spectrum with multiple genetic and environmental factors playing a role in disease pathogenesis [9,10].Together with clinical manifestations, the histopathological and immunopathological data support the diagnosis of the disease. The best site for the cutaneous biopsy for the appropriate histopathological examination is a fresh (< 24 h) small vesicle or 1/3 of the peripheral portion of the blister including the perilesional normal appearing s...

show abstract

Cobblestone mouth: An exuberant oral presentation of pemphigus vegetans

Cited by 4 publications

References 3 publications

Multiple vegetating plaques on a Cesarean section scar

Multiple vegetating plaques on a Cesarean section scar

Atypical Clinical and Serological Manifestation of Pemphigus Vegetans: A Case Report and Review of the Literature

Pemphigus: Subtypes, Clinical Features, Diagnosis, and Treatment

Contact Info

Product

Resources

About