Cobalt related interstitial lung disease

Adams, Traci N.; Butt, Yasmeen M.; Batra, Kiran; Glazer, Craig S.

doi:10.1016/j.rmed.2017.06.008

Cited by 32 publications

(21 citation statements)

References 49 publications

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“…Hard metal has been widely used in industry since its development by the Germans in 1920s (Nemery et al, 2001). Since then, workers with ILD under hard metal dust exposure were recognized in Germany in 1940s (Adams et al, 2017). Later on, HMLD was firstly described by Liebow and Carrington (1969) with the histological term GIP.…”

Section: Discussionmentioning

confidence: 99%

“…Hard metal is a generic term for a synthetic compound that contains approximately 90% of tungsten carbide and 10% of cobalt and other metals such as tantalum, titanium, nickel, niobium, and chrome. As it has the unusual hardness of the matrix, with great strength, heat resistance, and resistance to oxidation, hard metal has widespread applications such as drill bits, grinding wheels, cut tools, and engines in industries (Adams et al, 2017). The exposure to hard metal dust may induce allergic disorders, such as contact dermatitis, and occupational asthma and interstitial lung disease (ILD), namely HMLD with a histologic pattern of giant cell interstitial pneumonia (GIP).…”

Section: Introductionmentioning

confidence: 99%

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Cobalt-related interstitial lung disease or hard metal lung disease: A case series of Chinese workers

Liu

Jin

et al. 2021

Toxicol Ind Health

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Hard metal lung disease (HMLD) is rarely diagnosed and is caused by the occupational inhalation of hard metal dust, mainly cobalt. The diagnosis of HMLD is based on a thorough occupational dust exposure combined with clinical–radiological–histological findings. We present a series of four Chinese workers who had occupational exposure to cobalt acid lithium or cobalt and tungsten dust. Four patients all complained of intermittent cough, chest tightness, or shortness of breath on exertion. High-resolution computed tomography scans presented bilateral ground-glass attenuation, consolidations, and/or reticular opacities with diffuse small nodules. Histologic findings showed that interstitial inflammation and fibrotic lesions distributed peribronchioles. The infiltrations by macrophages as well as visible multinucleated giant cells indicated giant cell interstitial pneumonia (GIP). Cobalt was detectable in the lung tissues of two patients measured by inductively-coupled plasma mass spectrometry. The first patient was diagnosed with cobalt-related interstitial lung disease (ILD), while the others were HMLD. GIP is the classic pathology of cobalt-related ILD or HMLD. One of the patients showed spontaneous remission after the cessation of exposure, while the other three recovered within 6–32 weeks after avoiding occupational exposure and using corticosteroids. At follow-up, all four patients showed no recurrence. A multidisciplinary diagnostic panel including occupational cobalt exposure evaluation is beneficial to recognize cobalt-related ILD or HMLD and to indicate the necessity of prevention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cobalt-related interstitial lung disease or hard metal lung disease: A case series of Chinese workers

Liu

Jin

et al. 2021

Toxicol Ind Health

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“…Exposure to hard metal causes asthmatic reaction, hypersensitivity pneumonitis, and pulmonary fibrosis [30]. Patients typically present with hard metal interstitial lung disease after 10-12 years of exposure, but the disease can occur in as little as 2 years [31].…”

Section: Hard Metal Pneumoconiosismentioning

confidence: 99%

“…Peripheral cystic spaces are reported in some cases [28,33,40]. Lymph node enlargement and spontaneous pneumothorax have been reported [30].…”

Section: Hard Metal Pneumoconiosismentioning

confidence: 99%

Imaging diagnosis of classical and new pneumoconiosis: predominant reticular HRCT pattern

Akira

2021

Insights Imaging

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Our understanding of the manifestations of pneumoconioses is evolving in recent years. Associations between novel exposures and diffuse interstitial lung disease have been newly recognized. In advanced asbestosis, two types of fibrosis are seen, probably related to dose of exposure, existence of pleural fibrosis, and the host factor status of the individual. In pneumoconiosis of predominant reticular type, nodular opacities are often seen in the early phase. The nodular pattern is centrilobular, although some in metal lung show perilymphatic distribution, mimicking sarcoidosis. High-resolution computed tomography enables a more comprehensive correlation between the pathologic findings and clinically relevant imaging findings. The clinician must understand the spectrum of characteristic imaging features related to both known dust exposures and to historically recent new dust exposures.

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“…Despite the established CDC criteria to assist in identifying EVALI cases, there are a variety of respiratory diseases that may present similarly or even in association with EVALI [15,19]. The differential diagnosis, outside of community acquired pneumonia (CAP) and viral pneumonia, includes parenchymal lung diseases such as acute eosinophilic pneumonia, organizing pneumonia, hypersensitivity pneumonia, lipoid pneumonia, diffuse alveolar hemorrhage, giant cell pneumonitis, and RB-ILD, and cardiac causes such as congestive heart failure [11,13,15,20,21,[35][36][37][38][39][40].…”

Section: Diagnosismentioning

confidence: 99%

E-cigarette, or vaping, product use-associated lung injury: a review

et al. 2020

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Background E-cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI) is a disease entity related to the use of battery-operated or superheating devices that create an aerosolized form of nicotine and tetrahydrocannabinol (THC) and/or other substances for inhalation. Methods We performed a literature review to document epidemiology, pathogenesis and risk factors, diagnosis, clinical presentation, evaluation and management of EVALI. Results In the summer of 2019, an outbreak of EVALI cases brought this disease entity into the national spotlight. Since being recognized as a serious pulmonary disease with public health implications, more than 2600 cases have been reported to CDC with 68 deaths as of February 2020. The pathophysiology of EVALI remains unknown. Substances such as Vitamin E acetate have been implicated as a possible causes of lung injury. The CDC has established case definitions of “confirmed EVALI” cases to help guide identification of the disease and assist in surveillance. While clinical judgement by healthcare providers is imperative in the identification of EVALI cases, the heterogeneous presentations of EVALI make this difficult as well. Ultimately most investigative studies should be aimed at ruling out other disease processes that can present similarly. Treatment is centered around removing the offending substance and providing supportive care. Conclusions EVALI is a serious pulmonary disease with public health implications. Diagnosis requires a high degree of suspicion to diagnose and exclusion of other possible causes of lung disease. It may be beneficial to involve a pulmonary specialist early in the management of this disease which is generally supportive care.

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Cobalt related interstitial lung disease

Cited by 32 publications

References 49 publications

Cobalt-related interstitial lung disease or hard metal lung disease: A case series of Chinese workers

Cobalt-related interstitial lung disease or hard metal lung disease: A case series of Chinese workers

Imaging diagnosis of classical and new pneumoconiosis: predominant reticular HRCT pattern

E-cigarette, or vaping, product use-associated lung injury: a review

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