2022
DOI: 10.1016/j.molstruc.2021.132266
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Cobalt(II), nickel(II), copper(II) and zinc(II) complexes of thiadiazole based Schiff base ligands: Synthesis, structural characterization, DFT, antidiabetic and molecular docking studies

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Cited by 82 publications
(34 citation statements)
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“…The in vitro antimicrobial activity of the synthesized Schiff base ligands ( 1–3 ) and their corresponding diorganotin(IV) complexes ( 4–15 ) was evaluated against two Gram-positive ( Staphylococcus aureus MTCC 2901 and Bacillus subtilis MTCC 441), two Gram-negative ( Escherichia coli MTCC 732 , Pseudomonas aeruginosa MTCC 424) bacterial and two fungal ( Candida albicans MTCC 227 , Aspergillus niger MTCC 9933) strains using serial dilution method [ 32 – 34 ]. The results were reported in terms of MIC (µmol/mL).…”
Section: Methodsmentioning
confidence: 99%
“…The in vitro antimicrobial activity of the synthesized Schiff base ligands ( 1–3 ) and their corresponding diorganotin(IV) complexes ( 4–15 ) was evaluated against two Gram-positive ( Staphylococcus aureus MTCC 2901 and Bacillus subtilis MTCC 441), two Gram-negative ( Escherichia coli MTCC 732 , Pseudomonas aeruginosa MTCC 424) bacterial and two fungal ( Candida albicans MTCC 227 , Aspergillus niger MTCC 9933) strains using serial dilution method [ 32 – 34 ]. The results were reported in terms of MIC (µmol/mL).…”
Section: Methodsmentioning
confidence: 99%
“…Deswal et al, (2022) [ 78 ] recently reported a study on transition metal complexes, namely cobalt (II), nickel(II), copper(II), and zinc(II), with SB ligands and their potential antidiabetic activity by in vitro experiments on α-amylase and α-glucosidase enzymes. Complexes 25 and 26 showed good activities with IC 50 values close to those of the standard acarbose (IC 50 = 1.28 ± 0.05 and 0.58 ± 0.06 μmol/mL, respectively).…”
Section: Mononuclear Sbs Complexesmentioning
confidence: 99%
“…These studies concluded that transition metal complex can increase the tolerance of pancreatic 𝛽-cells against oxidative stress, which is one of the responsible agents of diabetes. [22][23][24] Some complex triazole derivatives increase in glucose tolerance and consequently decrease in blood glucose level. [25] The mechanism of action of some transition metals has been suggested that metal ion treats hyperglycemia by activating the phosphoinositide 3-kinase pathway.…”
Section: In Vitro Antidiabetic Activitymentioning
confidence: 99%