Cobalt(II) catalyzed dehydration of aldoximes: A highly efficient practical procedure for the synthesis of nitriles

Half‐Sandwich Guanidinate–Osmium(II) Complexes: Synthesis and Application in the Selective Dehydration of Aldoximes

“…[13] More appealing protocols have emerged in recent years employing metal catalysts, which usually operate under milder reaction conditions and with higher functional group compatibility. In this context, efficient catalytic systems involving Re, [14] Fe, [15] Ru, [16] Co, [17] Rh, [18] Ni, [19] Pd, [20] Cu, [21] Zn, [22] Ga, [23] and In [24] have been reported. To the best of our knowledge, complexes 3a-m are the first examples of osmium compounds able to catalyze the dehydration of aldoximes.…”

Silica supported heteropolyacid catalyzed dehydration of aldoximes to nitriles and alcohols to alkenes

“…Alternatively, nitriles are also synthesized by dehydration of aldoximes and this transformation has been widely studied. Various catalytic systems including CoCl 2 (15), KF/Al 2 O 3 (16), WÁSn hydroxide (17), ZnO/CH 3 COCl (18), metal triflates (19,20), clay (21), and zeolites (22), are reported for dehydration of aldoximes to nitriles. Some non-conventional techniques like use of microwaves (23,24) have also been reported.…”

Application of Infrared Spectroscopy in Catalysis: Impacts on Catalysts’ Selectivity

“…The most efficient route for the synthesis of nitriles is the dehydration of aldoximes that can easily be obtained from the corresponding aldehydes. Homogeneous catalytic systems such as Pd(II) complexes with a phosphino-oxime ligand [38], Co(II)Cl 2 [39], Ga(OTf) 3 [40], and Fe(ClO 4 ) 3 [41] are employed with interesting performance but presenting important limitations such as catalyst recovery, use of hazardous organic solvents, and long reaction time. Therefore, a lot of attention is paid in developing alternative heterogeneous catalysts.…”