Cobalt-Catalyzed Stereospecific C–N/C–O Bond Formation of Oxiranes with Diaziridines

Abstract

Co-catalyzed stereospecific C−N and C−O bond formation of oxiranes with diaziridines has been accomplished to furnish tetrahydro-[1,3,4]-oxadiazines at room temperature. Optically active oxiranes can be coupled with high optical purities (>96% ee). Stereoselectivity, functional group tolerance, mechanistic studies using DFT, and natural product modification are the important practical features.

Enthalpy of formation of 6-phenyl-1,5-diazabicyclo[3.1.0]hexane by combustion calorimetry and theoretical approach for efficient prediction of thermochemistry of diaziridines

“…These transformations can be induced by diverse reagents, thermolysis, microwave heating and catalysts. 1–9 A wide range of pharmaceuticals, agrochemicals and other biologically active compounds can be produced using these different types of transformations. In particular, diaziridine derivatives exhibit neurotropic activity and new efficient antidepressant drugs have been created on the basis of these compounds.…”