Coating of pellets with micronized ethylcellulose particles by a dry powder coating technique

Pearnchob, Nantharat; Bodmeier, Roland

doi:10.1016/j.ijpharm.2003.07.012

Cited by 78 publications

(18 citation statements)

References 22 publications

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“…Some coating processes like hotmelting coating (17), compression coating (18,19) and dry powder coating (20,21) have been investigated and widely used within the paint and automobile industries.…”

Section: Discussionmentioning

confidence: 99%

Sustained release vancomycin-coated titanium alloy using a novel electrostatic dry powder coating technique may be a potential strategy to reduce implant-related infection

Yang

Wang

et al. 2017

BST

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Section: Discussionmentioning

confidence: 99%

Sustained release vancomycin-coated titanium alloy using a novel electrostatic dry powder coating technique may be a potential strategy to reduce implant-related infection

Yang

Wang

et al. 2017

BST

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“…[22][23][24] EC has been used widely as a coating material for drugs. 25,26 Using SEM, the microparticles produced were seen to be smooth and spherical. EDS confirmed the presence of calcium hydroxide in all microparticles.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of biodegradable microcapsules for the controlled delivery of calcium hydroxide

et al. 2011

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This study aimed to synthesize and characterize biodegradable microcapsules based on poly(lactic acid) (PLA) and ethylcellulose (EC) for a controlled delivery of calcium hydroxide. Phase separation technique was adopted to synthesize calcium hydroxide-loaded PLA/EC microcapsules. Four PLA/EC blends (4/1, 1/1, 1/4, pure EC) were used as shell materials and the input ratio of calcium hydroxide to shell polymer was 4:1 for all microcapsules. The morphology and composition were studied using SEM-EDS and TEM. Particle size distribution, glass-transition temperature, drug loading, and encapsulation efficiency were characterized. In vitro release of the microcapsules was evaluated using a pH microelectrode and an auto-biochemistry analyzer. SEM images of microcapsules showed uniform spherical structures with smooth surfaces. Core-shell, hetero-structures were confirmed using TEM. The presence of calcium in the microcapsules was verified with EDS. Pure calcium hydroxide was 160 nm in diameter and the particle size of the microcapsules ranged between 500 nm and 4 μm. With an increase of PLA in PLA/EC blend, the size of microcapsules increased accordingly. Encapsulation efficiency of these microcapsules was higher than 57% and drug loading was higher than 80%, which were not significantly different among four microcapsules. Pure calcium hydroxide powder was used as a control and 90% was released within 48 h, while release of calcium hydroxide from microcapsules took between 168 and 456 h, depending on the PLA/EC ratio. Compared with calcium hydroxide powder, the calcium hydroxide-loaded microcapsules showed a sustained and prolonged release, which could be controlled via the regulation of the PLA/EC ratio.

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“…18 Drug release from the formulation is depends on the nature and type of polymers used in it. The coating polymers which were used in the study was Eudragit RL-100 (ERL) and S100 (ERS).…”

Section: Discussionmentioning

confidence: 99%

Effect of curing time on ph and time dependant coated pellets

Kadam¹,

Gattani²

2010

Int J Health Res

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an online international journal allowing free unlimited access to abstract and full-text of published articles. The journal is devoted to the promotion of health sciences and related disciplines (including medicine, pharmacy, nursing, biotechnology, cell and molecular biology, and related engineering fields). It seeks particularly (but not exclusively) to encourage multidisciplinary research and collaboration among scientists, the industry and the healthcare professionals. It will also provide an international forum for the communication and evaluation of data, methods and findings in health sciences and related disciplines. The journal welcomes original research papers, reviews and case reports on current topics of special interest and relevance. All manuscripts will be subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication) will be published without delay. The maximum length of manuscripts should normally be 10,000 words (20 single-spaced typewritten pages) for review, 6,000 words for research articles, 3,000 for technical notes, case reports, commentaries and short communications. Submission of Manuscript:The International Journal of Health Research uses a journal management software to allow authors track the changes to their submission. All manuscripts must be in MS Word and in English and should be submitted online at http://www.ijhr.org. Authors who do not want to submit online or cannot submit online should send their manuscript by e-mail attachment (in single file) to the editorial office below. Submission of a manuscript is an indication that the content has not been published or under consideration for publication elsewhere. Authors may submit the names of expert reviewers or those they do not want to review their papers. Enquiries Original Research Article Effect of Curing Time on pH and Time Dependant Coated PelletsReceived: 29-Dec-08Revised: 10-Jan-09 Accepted: 11-Jan-09Abstract PURPOSE: The drug release from coated pellets depends on many process and formulation variables, including plasticization, curing treatment, and properties of the core. In this study, effect of currying on eudragit coated pellets was investigated. METHODS: Theophylline loaded pellets were coated with a non aqueous time and pH dependant eudragit solution. The coated pellets were cured at constant process parameters (45°C) for different time periods (05, 10, or 20 min) and the drug release profile and other characteristics of formulation were evaluated. RESULTS:In vitro release studies shows retardation of drug release from the coated pellets. The DSC thermogram revealed no interaction between the polymer and drug in the formulation. The SEM data shows no change in the surface topography after 20 min curing. CONCLUSION:In general, curing reduced the drug release and resulted in stable drug release profiles.

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Coating of pellets with micronized ethylcellulose particles by a dry powder coating technique

Cited by 78 publications

References 22 publications

Sustained release vancomycin-coated titanium alloy using a novel electrostatic dry powder coating technique may be a potential strategy to reduce implant-related infection

Sustained release vancomycin-coated titanium alloy using a novel electrostatic dry powder coating technique may be a potential strategy to reduce implant-related infection

Synthesis and characterization of biodegradable microcapsules for the controlled delivery of calcium hydroxide

Effect of curing time on ph and time dependant coated pellets

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