Sustained release vancomycin-coated titanium alloy using a novel electrostatic dry powder coating technique may be a potential strategy to reduce implant-related infection

Yang, Yi; Lu, Jinghao; Wang, Chenzhong; Xie, Yi; Zheng, Xuebin; Yao, Zhenjun; Zhang, Chi

doi:10.5582/bst.2017.01061

Cited by 26 publications

(18 citation statements)

References 22 publications

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“…Although TiO 2 itself has a certain degree of antibacterial effects when induced by UV light, the effects are limited since the photocatalytic effect of TiO 2 alone is extremely transient 12 , 38 . Researchers have introduced antibiotics and metal nanoparticles onto titanium implant scaffolds to enhance bacteriostatic efficacy, but these studies still exhibit various drawbacks 14 , 15 . In this study, we changed the zeta potential of TiO 2 nanofibers to positive and the charge of a novel two-dimensional carbon-based nanomaterial, GDY, to negative to synthesize a GDY-combined TiO 2 heterojunction to enhance the photocatalytic effect 39 , 40 .…”

Section: Discussionmentioning

confidence: 99%

“…Theoretically, TiO 2 as a photocatalytic material can produce reactive oxygen species (ROS) to kill bacteria under UV irradiation 12 , while the recombination of generated electrons and holes reduces the photocatalytic performance of TiO 2 and restricts its practical antibacterial effects 13 . Recently, researchers have loaded antibiotics, metal nanoparticles, and other antimicrobial elements onto TiO 2 surfaces for antibacterial applications [13][14][15][16] . However, the bacterial resistance arising from antibiotic application and the potential cytotoxicity of metal nanoparticles limit their clinical applications.…”

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confidence: 99%

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Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

et al. 2020

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Titanium implants have been widely used in bone tissue engineering for decades. However, orthopedic implant-associated infections increase the risk of implant failure and even lead to amputation in severe cases. Although TiO2 has photocatalytic activity to produce reactive oxygen species (ROS), the recombination of generated electrons and holes limits its antibacterial ability. Here, we describe a graphdiyne (GDY) composite TiO2 nanofiber that combats implant infections through enhanced photocatalysis and prolonged antibacterial ability. In addition, GDY-modified TiO2 nanofibers exert superior biocompatibility and osteoinductive abilities for cell adhesion and differentiation, thus contributing to the bone tissue regeneration process in drug-resistant bacteria-induced implant infection.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

et al. 2020

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“…The development of antibacterial metals has been in use with antibacterial metal ions such as silver and copper, or antibacterial agents such as iodine and vancomycin ( Ando et al, 2010 ; Shirai et al, 2011 ; Han et al, 2017 ; Wang et al, 2019 ). However, there is a risk that these added toxic substances have the potential to leak into the bloodstream and result in subsequent side effects ( Punjataewakupt et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Kurishima

Mori

Inoue

et al. 2022

Front. Bioeng. Biotechnol.

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In this study, we anodized a TiNbSn alloy with low Young’s modulus in an electrolyte of sodium tartrate with and without hydrogen peroxide (H2O2). The photo-induced characteristics of the anodized alloy were analyzed for crystallinity and electrochemical conditions with comparisons to the effect with the addition of H2O2. The antibacterial activity was evaluated using methicillin-resistant Staphylococcus aureus and other pathogenic bacteria according to ISO 27447, and time decay antibacterial tests were also conducted. The anodized oxide had a porous microstructure with anatase- and rutile-structured titanium dioxide (TiO2). In contrast, the peaks of rutile-structured TiO2 were accelerated in the anodized TiNbSn alloy with H2O2. The formation of hydroxyl radicals and methylene blue breaching performance under ultraviolet irradiation was confirmed in the anodic oxide on TiNbSn alloy with and without H2O2. The anodic oxide on TiNbSn alloy had a robust antibacterial activity, and no significant difference was detected with or without H2O2. We conclude that anodized TiNbSn alloy with sodium tartrate electrolyte may be a functional biomaterial with a low Young’s modulus and an antibacterial function.

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“…A local release system on the implant surface is an excellent idea as its local drug infusion and barrier effect on resisting biofilm formation which cause implant-related infections [30]. In order to tackle the implant-related infection, a sustained release antibacterial coated implant might support systemic antibiotic prophylaxis in preventing implant-associated infection [31].…”

Section: Discussionmentioning

confidence: 99%

Transglutaminase Cross-Linked Gelatin-Alginate-Antibacterial Hydrogel as the Drug Delivery-Coatings for Implant-Related Infections

Sun

Lin

et al. 2021

Polymers

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Implant-related infection may be catastrophic and result in poor functional outcome, chronic osteomyelitis, implant failure or even sepsis and death. Based on a transglutaminase (TGase) cross-linked/antibiotics-encapsulated gelatin-alginate hydrogel, the main aim of this study is to establish an effective antibiotic slow-release system. The second aim is to evaluate the efficacy of a hydrogel-encapsulated antibiotic-containing titanium pin in preventing implant-related infections in a rat model. The prepared gelatin/alginate/gentamicin or vancomycin hydrogel was covalently cross-linked with transglutaminase (TGase). Its drug release profile and cytotoxicity were determined and the Wistar rat animal model was performed to validate its efficacy by radiographic examination, Micro-CT (computed tomography) evaluation and histo-morphological analysis at 12 weeks after surgery. When gelatin and alginate were thoroughly mixed with TGase, both 0.5% and 1.0% TGase can effectively cross link the hydrogel; the release of antibiotic is slowed down with higher degree of TGase concentration (from 20 min to more than 120 h). In the animal study, antibiotic-impregnated hydrogel is effective in alleviating the implant-related infections. Relative to that of a positive control group, the experimental group (vancomycin treatment group) showed significant higher bone volume, more intact bony structure with only mild inflammatory cell infiltration. This newly designed hydrogel can effectively deliver antibiotics to reduce bacterial colonization and biofilm formation on the implant surface. The remaining challenges will be to confer different potent antibacterial medications with good biocompatibility and fulfill the safety, practical and economic criteria for future clinical translation.

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Sustained release vancomycin-coated titanium alloy using a novel electrostatic dry powder coating technique may be a potential strategy to reduce implant-related infection

Cited by 26 publications

References 22 publications

Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Transglutaminase Cross-Linked Gelatin-Alginate-Antibacterial Hydrogel as the Drug Delivery-Coatings for Implant-Related Infections

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