Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteins

Wey, K; Schirrmann, R; Diesing, Detlef; Lang, Stephan; Brandau, Sven; Hansen, Stefan; Epple, Matthias

doi:10.1016/j.biomaterials.2021.121009

Cited by 7 publications

(7 citation statements)

References 85 publications

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“…In another study by Wey et al, a CI electrode coated with calcium phosphate (CaP) nanoparticles modified by DNA encoding neurotrophic factors was fabricated through the layer-by-layer technique. 77 To prevent the degradation of alien DNA by nuclease in vivo, the nanoparticles were prepared by precipitation method, and polyethylene imine or carboxymethyl cellulose was used as the substrate to stabilize DNA. 79 It was suggested that the electrode coating with nanoparticles carrying nucleic acids promoted the outgrowth of SGNs, thereby improving the transmission of electrical pulses (Figure 6B).…”

Section: Electrode Coatingmentioning

confidence: 99%

Section: Electrical Stimulationmentioning

confidence: 99%

“… 76 Their results demonstrated that the modified CI resulted in the reduced impedance, promoted charge transfer, and released brain derived neurotrophic factor into the cochlea, indicating a great improvement in device performance after the above coating. In another study by Wey et al., a CI electrode coated with calcium phosphate (CaP) nanoparticles modified by DNA encoding neurotrophic factors was fabricated through the layer‐by‐layer technique 77 . To prevent the degradation of alien DNA by nuclease in vivo, the nanoparticles were prepared by precipitation method, and polyethylene imine or carboxymethyl cellulose was used as the substrate to stabilize DNA 79 .…”

Section: Biomedical Engineering Technologies For Hearing Reconstructionmentioning

confidence: 99%

Section: Biomedical Engineering Technologies For Hearing Reconstructionmentioning

confidence: 99%

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Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction

Hu,

Fang,

Zhang

et al. 2023

Smart Medicine

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Hearing impairment is a global health problem that affects social communications and the economy. The damage and loss of cochlear hair cells and spiral ganglion neurons (SGNs) as well as the degeneration of neurites of SGNs are the core causes of sensorineural hearing loss. Biotechnologies and biomedical engineering technologies provide new hope for the treatment of auditory diseases, which utilizes biological strategies or tissue engineering methods to achieve drug delivery and the regeneration of cells, tissues, and even organs. Here, the advancements in the applications of biotechnologies (including gene therapy and cochlear organoids) and biomedical engineering technologies (including drug delivery, electrode coating, electrical stimulation and bionic scaffolds) in the field of hearing reconstruction are presented. Moreover, we summarize the challenges and provide a perspective on this field.

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Section: Electrode Coatingmentioning

confidence: 99%

Section: Electrical Stimulationmentioning

confidence: 99%

Section: Biomedical Engineering Technologies For Hearing Reconstructionmentioning

confidence: 99%

Section: Biomedical Engineering Technologies For Hearing Reconstructionmentioning

confidence: 99%

See 2 more Smart Citations

Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction

Hu,

Fang,

Zhang

et al. 2023

Smart Medicine

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“…Calcium phosphate nanoparticle (CaP nanoparticles) is an excellent drug delivery system with good safety, biocompatibility and biodegradability [7][8][9]. CaP nanoparticles, namely amorphous calcium phosphate (ACP), can be formed by Ca 2+ and PO 4 3− in aqueous solution at room temperature [10].…”

Section: Introductionmentioning

confidence: 99%

MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer

et al. 2021

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Background Colon cancer is a most common malignant cancer in digestive system, and it is prone to develop resistance to the commonly used chemotherapy drugs, leading to local recurrence and metastasis. Paris saponin VII (PSVII) could not only inhibit the proliferation of colon cancer cells but also effectively induce apoptosis of drug-resistant colon cancer cells and reduce the metastasis of drug-resistant colon cancer cells as well. However, PSVII was insoluble in water and fat. It displayed no selective distribution in body and could cause severe hemolysis. Herein, colon cancer targeting calcium phosphate nanoparticles were developed to carry PSVII to treat drug-resistant colon cancer. Results PSVII carboxymethyl-β-cyclodextrin inclusion compound was successfully encapsulated in colon cancer targeting calcium phosphate nanoparticles (PSVII@MCP-CaP) by using modified citrus pectin as stabilizer agent and colon cancer cell targeting moiety. PSVII@MCP-CaP significantly reduced the hemolysis of PSVII. Moreover, by specific accumulating in orthotopic drug-resistant colon cancer tissue, PSVII@MCP-CaP markedly inhibited the growth of orthotopic drug-resistant colon cancer in nude mice. PSVII@MCP-CaP promoted the apoptosis of drug-resistant colon cancer cells through mitochondria-mediated apoptosis pathway. Moreover, PSVII@MCP-CaP significantly inhibited the invasion and migration of drug-resistant colon cancer cells by increasing E-cadherin protein expression and reducing N-cadherin and MMP-9 protein expression. Conclusion PSVII@MCP-CaP has great potential in the treatment of drug-resistant colon cancer. This study also explores a new method to prepare active targeting calcium phosphate nanoparticles loaded with a fat and water insoluble compound in water. Graphical Abstract

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A Review on Health Care Applications of Biopolymers

Vijesh

Isloor

2022

Biodegradable Materials and Their Applications

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Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteins

Cited by 7 publications

References 85 publications

Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction

Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction

MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer

A Review on Health Care Applications of Biopolymers

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