Coated Interpenetrating Blend Microparticles of Chitosan and Guar Gum for Controlled Release of Isoniazid

Abstract

This work reports on the novel development of IPN microparticles of chitosan (CS) and guar gum (GG) that are enteric coated with NaAlg and magnesium aluminum silicate (MAS) for controlled release of isoniazid. The matrices have been characterized by X-ray diffraction (XRD) to understand drug distribution, DSC for thermal stability, and Fourier transform infrared spectroscopy (FTIR) for investigating the chemical interactions of drug with the matrices. Surface morphology was investigated by scanning electron microscopy. These microparticles exhibited encapsulation efficiencies from 47 to 58%. Equilibrium swelling as well as in vitro release trends of the formulations studied in pH 1.2 and 7.4 buffer media showed the dependence of drug release on cross-linking, blend ratio of the matrix and coating, all of which affected the release time of drug from 1 to 4 h up to 50 h. The coated microparticles have reduced the burst release in gastric media to enhance in intestinal media.

Novel Composite Microparticles of Alginate Coated with Chitosan for Controlled Release and Protection of Ascorbic Acid

“…This could be explained that the characteristic peaks of AA had merged with the polymer blend matrix after the AA-loaded formulations, and finally inducing the amorphous nature of the phase. XRD results suggested a successfully molecular level dispersion of AA in the polymer blend matrix 42 and were consistent with the FT-IR data.…”

Novel Anti-Tubercular Compounds Based on Substituted 1,3,4-Thiadiazole are on the Uptrend

“…For instance, the coated Interpenetrating blend microparticles of chitosan and guar gum have effectively controlled released the INH in intestine [6]. Also, some novel pH-and temperature-responsive blend microspheres of sodium alginate and PNIPAAm-g-GG for controlled release of INZ have shown improved slow release profiles [7].…”

Application of N-hexoyl chitosan derivatives with high degree of substitution in the preparation of super-disintegrating pharmaceutical matrices

“…The resultant co-excipient was found to have much higher compressibility and disintegrating power than CS itself [24,27,53,54]. Furthermore, in order to enhance CS controlled release activity, it was mixed with other polymers such as sodium alginate [8,28], xanthan gum [4,23], hydroxyethyl cellulose [7], carrageenan [40], and guar gum [9].…”