Coarse-grained modeling of cell division in 3D: influence of density, medium viscosity, and inter-membrane friction on cell growth and nearest neighbor distribution

Madhikar, Pranav; Åström, Jan; Westerholm, Jan; Baumeier, Björn; Karttunen, Mikko

doi:10.1080/1539445x.2019.1706565

Cited by 5 publications

(6 citation statements)

References 95 publications

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“…A large number of different models has been used to describe cellular growth [29]. Here, we use the CELLSIM3D off-lattice growth model and simulator to study epithelial tissue growth [30,31]. In this model, cells can migrate, deform, divide, and interact with each other and their environment mechanically via adhesion and friction.…”

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confidence: 99%

In silico testing of the universality of epithelial tissue growth

Mazarei

Åström²,

Westerholm³

et al. 2022

Phys. Rev. E

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The universality of interfacial roughness in growing epithelial tissue has remained a controversial issue. Kardar-Parisi-Zhang (KPZ) and molecular beam epitaxy (MBE) universality classes have been reported among other behaviors including a total lack of universality. Here, we simulate tissues using the CELLSIM3D kinetic division model for deformable cells to investigate cell-colony scaling. With seemingly minor model changes, it can reproduce both KPZ-and MBE-like scaling in configurations that mimic the respective experiments. Tissue growth with strong cell-cell adhesion in a linear geometry is KPZ like, while weakly adhesive tissues in a radial geometry are MBE like. This result neutralizes the apparent scaling controversy.

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confidence: 99%

In silico testing of the universality of epithelial tissue growth

Mazarei

Åström²,

Westerholm³

et al. 2022

Phys. Rev. E

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“…The division algorithm is accounts for the planar expansion of epithelial tissue: The division plane is selected by randomly sampling a vector from a circle in the plane defined by the vector normal to the epithelial plane. To prevent buckling during growth, three-dimensional cells are confined between two frictionless plates with repulsion in the direction normal to the plates [42,48]. More details of the theoretical basis, the code implementation, and the mapping of the parameters can be found in Refs.…”

Section: A Cellsim3d Simulator and Modelmentioning

confidence: 99%

“…More details of the theoretical basis, the code implementation, and the mapping of the parameters can be found in Refs. [42,43,48]. Parameters for the simulations performed in this study are provided in Table I.…”

Section: A Cellsim3d Simulator and Modelmentioning

confidence: 99%

Effect of substrate heterogeneity and topology on epithelial tissue growth dynamics

Mazarei¹,

Åström²,

Westerlund³

et al. 2023

Preprint

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Tissue growth kinetics and interface dynamics depend on the properties of the tissue environment and cell-cell interactions. In cellular environments, substrate heterogeneity and geometry arise from a variety factors, such as the structure of the extracellular matrix and nutrient concentration. We used the CellSim3D model, a kinetic division simulator, to investigate the growth kinetics and interface roughness dynamics of epithelial tissue growth on heterogeneous substrates with varying topologies. The results show that the presence of quenched disorder has a clear effect on the colony morphology and the roughness scaling of the interface in the moving interface regime. In a medium with quenched disorder, the tissue interface has a smaller interface roughness exponent, α, and a larger growth exponent, β. The scaling exponents also depend on the topology of the substrate and cannot be categorized by well-known universality classes.

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“…A large number of different models has been used to describe cellular growth [29]. Here, we use the CellSim3D off-lattice growth model and simulator to study epithelial tissue growth [30,31]. In this model, cells can migrate, .…”

mentioning

confidence: 99%

“…This is consistent with earlier results in the sense that very rich growth behaviour and diverse tissues appear with modest changes, and, e.g., non-trivial dependencies in initial conditions, nutrients, apoptosis, disorder and mechanical forces from various sources cause changes in both quantitative and qualitative behaviors, see, e.g., Refs. [2,28,31,32,34].…”

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confidence: 99%

Epithelial Tissue Growth Dynamics: Universal or Not?

Mazarei¹,

Åström²,

Westerholm³

et al. 2022

Preprint

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Universality of interfacial roughness in growing epithelial tissue has remained a controversial issue. Kardar-Parisi-Zhang (KPZ) and Molecular Beam Epitaxy (MBE) universality classes have been reported among other behaviors including total lack of universality. Here, we utilize a kinetic division model for deformable cells to investigate cell-colony scaling. With seemingly minor model changes, it can reproduce both KPZ-and MBE-like scaling in configurations that mimic the respective experiments. This result neutralizes the apparent scaling controversy. It can be speculated that this diversity in growth behavior is beneficial for efficient evolution and versatile growth dynamics.

show abstract

Coarse-grained modeling of cell division in 3D: influence of density, medium viscosity, and inter-membrane friction on cell growth and nearest neighbor distribution

Cited by 5 publications

References 95 publications

In silico testing of the universality of epithelial tissue growth

In silico testing of the universality of epithelial tissue growth

Effect of substrate heterogeneity and topology on epithelial tissue growth dynamics

Epithelial Tissue Growth Dynamics: Universal or Not?

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