Coagulopathy and Brain Injury Pathogenesis in Post-Covid-19 Syndrome

Marzoog, Basheer Abdullah; Власова, Т. И.

doi:10.2174/1871525720666220405124021

Cited by 11 publications

(5 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…71 In turn, SARS-CoV-2 infection can be associated with an increased risk of thrombosis, also in the context of post-COVID-19 syndrome. 72 Importantly, the conducted investigations also demonstrated increased seroprevalence of anti-prothrombin antibodies in convalescents, which are implicated in the risk of thrombosis. 73 There are also reports on the autoantibodies against ACE2 that serves as the receptor for cellular entry of SARS-CoV-2.…”

Section: Autoantibodies Against Components Of the Cardiovascular Systemmentioning

confidence: 95%

“…It is known that these autoantibodies can be associated with coagulopathies and cardiac dysfunction 71 . In turn, SARS‐CoV‐2 infection can be associated with an increased risk of thrombosis, also in the context of post‐COVID‐19 syndrome 72 . Importantly, the conducted investigations also demonstrated increased seroprevalence of anti‐prothrombin antibodies in convalescents, which are implicated in the risk of thrombosis 73 …”

Section: Autoantibodies Against Components Of the Cardiovascular Systemmentioning

confidence: 99%

See 1 more Smart Citation

Overview of autoantibodies in COVID‐19 convalescents

Dobrowolska

Zarębska-Michaluk

Siller‐Matula

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

Accumulating evidence shows that SARS‐CoV‐2 can potentially trigger autoimmune processes, which can be responsible for the long‐term consequences of COVID‐19. Therefore, this paper aims to review the autoantibodies reported in COVID‐19 convalescents. Six main groups were distinguished: (i) autoantibodies against components of the immune system, (ii) autoantibodies against components of the cardiovascular system, (iii) thyroid autoantibodies, (iv) autoantibodies specific for rheumatoid diseases, (v) antibodies against G‐protein coupled receptors, and (vi) other autoantibodies. The evidence reviewed here clearly highlights that SARS‐CoV‐2 infection may induce humoral autoimmune responses. However, the available studies share number of limitations, such as: (1) the sole presence of autoantibodies does not necessarily implicate the clinically‐relevant risks, (2) functional investigations were rarely performed and it is often unknown whether observed autoantibodies are pathogenic, (3) the control seroprevalence, in healthy, noninfected individuals was often not reported; thus it is sometimes unknown whether the detected autoantibodies are the result of SARS‐CoV‐2 infection or the accidental post‐COVID‐19 detection, (4) the presence of autoantibodies was rarely correlated with symptoms of the post‐COVID‐19 syndrome, (5) the size of the studied groups were often small, (6) the studies focused predominantly on adult populations, (7) age‐ and sex‐related differences in seroprevalence of autoantibodies were rarely explored, (8) genetic predispositions that may be involved in generation of autoantibodies during SARS‐CoV‐2 infections were not investigated, and (9) the autoimmune reactions following infection with SARS‐CoV‐2 variants that vary in the clinical course of infection remain unexplored. Further longitudinal studies are advocated to assess the link between identified autoantibodies and particular clinical outcomes in COVID‐19 convalescents.

show abstract

Section: Autoantibodies Against Components Of the Cardiovascular Systemmentioning

confidence: 95%

Section: Autoantibodies Against Components Of the Cardiovascular Systemmentioning

confidence: 99%

Overview of autoantibodies in COVID‐19 convalescents

Dobrowolska

Zarębska-Michaluk

Siller‐Matula

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…The pathophysiology of MI involves an imbalance between myocardial oxygen demand and supply [11,12]. Subsequently, cardiac cells experience ischemia, leading to sequelae such as oxidative stress due to mitochondrial and cellular membrane deterioration [7,[13][14][15][16][17][18][19][20][21][22][23]. The lipid content of membranes plays a crucial role in cardiac cells regarding ischemia tolerance.…”

Section: Introductionmentioning

confidence: 99%

“…The pathophysiology of myocardial infarction includes a mismatch between the demand and supply of heart tissue with the blood [7,8] . Subsequently, cardiac cells start to suffer ischemia and is associated with sequalae, such as oxidative stress due to the deterioration of the mitochondrial bilayer membrane and cell membrane [3,9,18,19,[10][11][12][13][14][15][16][17] . The lipid content of membranes plays an essential role in cardiac cells in terms of ischemia, and, at the same time, maintaining stability during ischemia has a protective effect against ischemia [20] .…”

Section: Introductionmentioning

confidence: 99%

Early Prognostic Instrumental and Laboratory Biomarkers in Post-MI

Marzoog,

Vanichkina

2023

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Post-myocardial infarction (MI) changes have been reported frequently in the literature and are associated with the determination of the prognosis. Aims: To find a prognosis marker for the determination of the medium-term outcomes favorability in patients with acute MI. Objectives: MI victims prognosis is poorly understood and required further elaboration. Materials and methods: A single cross-sectional study involved 211 patients medical history with acute MI have been evaluated retrospectively for 76 parameters for the period 2014-2019. The data has been collected from the republic rehabilitation Mordovian hospital. Measurement units are used in the local laboratories has been used to describe the gotten values. The descriptive values are described in the mean average and standard deviation. For statistical analysis, descriptive statistics, t-test independent by groups and dependent by numerical variables for repeated analysis for the same patients, Pearsons correlation coefficient, ROC analysis, Stepwise Model Builder- logistic regression analysis, and for clarification purposes used diagrams and bar figures. For statistical analysis used the Statistica program. Results: Descriptive statistics showed a proportion of men to female 7:3. The mean age of the MI victims was 61,50 years (Std.Dev. 10,6875) and the mean height of the sample was 171,00 cm (Std.Dev. 7,2007). The mean body weight of the sample is 83,62 kg (Std.Dev. 12,3526) and the body mass index (BMI) is 29,02 kg/m2 (Std.Dev. 5,0791). The mean total hospitalization days is 14,79 (Std.Dev. 3,4125) days. The mean heart rate (HR) beat per minute (bpm) 79,03 (Std.Dev. 15,6370) and mean blood pressure 138,53/84,09 mmHg (Std.Dev. 28,6691/12,7971). On the complete blood count (CBC), the mean level of the hemoglobin (Hb) 136,332 g/l (Std.Dev. 15,2923), the mean level of the leukocytes (WBC) 8,768 /microL (Std.Dev. 2,7771), the mean level of the red blood cells (RBC) 4,559 /microL (Std.Dev. 0,5211), the mean level of the lymphocytes 24,469 % (Std.Dev. 9,0153), and the mean level of the thrombocytes 207,877 /microL (Std.Dev. 64,0350). The means erythrocytes segmentation rate (ESR) 18,990 mm/hr (Std.Dev. 12,1630). Conclusions: The gender plays an essential role for the development of ischemic heart disease including MI. The cut age in which females develop MI ≥73 years old. Patients with concomitant diseases have a high diastolic blood pressure and right ventricle size enlargement. The observed early post MI complication include left ventricle aneurysm and reinfarction. Others: a high calcium level is not a marker in hypertensive patients.

show abstract

“…Recently emerging data indicate that microclotting and localized neuroinflammation are complementary factors in the development of persistent Long neurological COVID (Marzoog 2022). Markers of systemic inflammation (e.g., serum-derived IL-6, IL-8, galectin-9, etc.)…”

Section: Introductionmentioning

confidence: 99%

Post-Concussion Assessment as a diagnostic and mechanistic framework for treating patients with Long COVID

Davidson

Noteboom

Pierro

et al. 2022

Preprint

View full text Add to dashboard Cite

IntroductionDespite first coming into view over two years ago, effective diagnostic and treatment pathways for Long COVID continue to evade the medical community. The overlap in neurological-based symptoms and neuroinflammatory origin indicates that the framework of post-concussion syndrome may provide insight into new diagnostics and treatment for patients with Long COVID. The objective of this investigation was to determine whether tools from the four common domains of concussion assessment were sensitive to differentiate between patients with Long COVID from a reference group who was infected with Sars-CoV-2 and does not have Long COVID.MethodsIn this prospective cohort design, each participant self reported their group (Acute, n=28) and Long COVID Group (n=33). Each participant underwent an examination in four assessment categories: symptoms, vestibular nystagmography, Automated Neuropsychological Assessment Metrics (ANAM), and a series of balance tasks.ResultsTotal Symptom scores were separated into functional classifications and showed clear success as a tool to differentiate between Acute and Long COVID. Five of the 33 people in the Long COVID had detectable central lesions, which increases the risk of developing long COVID by 64% (Relative Risk=1.64). A wide variety of objective and quantitative measures from post-concussion care are sensitive to the Long COVID condition. Prolonged latency during random saccades eye tracking was present (p<0.01, d=0.87) in the Long COVID group corresponding to the King-Devick rapid reading test, which was highly sensitive to Long COVID (p<0.01, d=1.34). ANAM reaction time subtests had similarly large effects (p<0.01, d=0.93-1.09). Balance performance with corrupted sensory feedback was also sensitive (p<0.01, d=0.96).DiscussionOur results indicate that long-standing and validated post-concussion symptom questionnaires may be used for quantifying the severity of Long COVID. Some of the most sensitive measures (especially the King-Devick rapid reading test) are easy to implement clinically and may be effective at tracking patient progress in the context of Long COVID treatment. The results point to wide deficits in motor integration and provide a rationale for treating the subset of Long COVID patients with similar rehabilitation strategies as patients with post-concussion syndrome.

show abstract

Coagulopathy and Brain Injury Pathogenesis in Post-Covid-19 Syndrome

Cited by 11 publications

References 106 publications

Overview of autoantibodies in COVID‐19 convalescents

Overview of autoantibodies in COVID‐19 convalescents

Early Prognostic Instrumental and Laboratory Biomarkers in Post-MI

Post-Concussion Assessment as a diagnostic and mechanistic framework for treating patients with Long COVID

Contact Info

Product

Resources

About