Coagulation support algorithm with rapid TEG and functional fibrinogen TEG in critical bleeding: more results and less time

Blasio, E De; Pellegrini, C; Federico, Alessandro Di; Rocco, Vincenzo; Fumi, Maurizio; Pancione, Ylenia; Sale, Silvia; Liberti, D

doi:10.1186/cc14432

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…The assays include Kaolin TEG, Kaolin TEG with heparinase, Rapid-TEG ® , and TEG Functional fibrinogen ® [3]. By superimposing the results of different assays, a detailed clinical picture of haemostasis can be seen in as little as 10 min [4]. The TEG6S measures clot viscoelasticity throughout the coagulation process by using resonance technology, exposing the blood sample to a fixed vibration frequency [5, 6].…”

Section: Introductionmentioning

confidence: 99%

Assessment of agreement and interchangeability between the TEG5000 and TEG6S thromboelastography haemostasis analysers: a prospective validation study

Lloyd-Donald

Чурилов²,

Zia

et al. 2019

BMC Anesthesiol

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Background TEG6S ® and TEG5000 ® (Haemonetics Corp, USA) are haemostasis analysers that measure viscoelasticity properties of whole blood. Both use different mechanisms to assess similar components of the coagulation process. The aim of this study was to assess agreement and interchangeability between the TEG6S and TEG5000 analysers. Methods 3.5 mL whole blood was collected from 25 adult patients in a tertiary intensive care unit (ICU). Analysis was performed using TEG6S and TEG5000 haemostatic platforms. Agreement between platforms was measured using Lin’s concordance coefficient (Lin’s CC), further validated using intraclass correlation coefficients and reduced major axis regression (RMAR). Results Sixteen (64%) patients were male; mean (range) age: 59yo (23–86). TEG6S and TEG5000 systems were broadly interchangeable. The majority of TEG variables demonstrated almost perfect or substantial agreement and minimal proportional bias (maximum amplitude demonstrated a fixed bias). LY30%, however, demonstrated poor agreement and a proportional bias. Lin’s CC coefficients (95% CI, RMAR slope, intercept) between TEG6S and TEG5000 variables were: R time: 0.78 (0.64–0.92, 0.76, 0.92); K time: 0.82 (0.69–0.94, 1.30, − 0.93); alpha angle: 0.79 (0.64–0.95, 1.04, − 1.43); maximum amplitude (MA): 0.90 (0.83–0.96, 0.99, − 5.0); LY30%: 0.34 (0.1–0.58, 0.43, 0.04). Conclusions Adult patients with critical illness demonstrate almost perfect agreement in the R time and MA, substantial agreement in K time and alpha angle, but poor agreement in LY30%, as measured by the TEG6S and TEG5000 analysers. With the exception of LY30%, the TEG6S and TEG5000 platforms appear interchangeable. This has important implications for use in clinical practice and multi-site research programs. Trial registration ANZCRT number: 12617000062325 , registered 12/Jan17. Retrospectively registered. Electronic supplementary material The online version of this article (10.1186/s12871-019-0717-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Assessment of agreement and interchangeability between the TEG5000 and TEG6S thromboelastography haemostasis analysers: a prospective validation study

Lloyd-Donald

Чурилов²,

Zia

et al. 2019

BMC Anesthesiol

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“…This process is fully automated, which eliminates the need for manual pipetting, simplifying and standardising the process. From a single blood sample, the TEG6S also enables multiple assays (citrated kaolin, heparinase kaolin, rapid TEGs and functional fibrinogen) to be performed simultaneously, in contrast to the TEG5000 system that only permits a single assay to be run at a given time 7,8 .…”

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confidence: 99%

Assessing TEG6S reliability between devices and across multiple time points: A prospective thromboelastography validation study

Lloyd-Donald

Чурилов

Cheong

et al. 2020

Sci Rep

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The TEG6S is a novel haemostasis analyser utilising resonance technology. It offers potentially greater coagulation information and ease of use, however has not been independently validated in a clinical setting. We aimed to determine if the TEG6S is reliable between devices and across time points. We performed a prospective observational study with ethical approval. For interdevice reliability, we performed simultaneous analysis on two TEG6S devices on 25 adult ICU patients. For time point reliability, we performed repeated sampling across five different time points on 15 adult participants. Blood was collected with informed consent, or as standard care, before four-channel citrated kaolin analysis. We observed almost perfect interdevice reliability across all TEG parameters.

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Whole Blood Assay: Thromboelastometry – Basics

Görlinger

Iqbal

Dirkmann

et al. 2021

Management of Bleeding Patients

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Coagulation support algorithm with rapid TEG and functional fibrinogen TEG in critical bleeding: more results and less time

Cited by 3 publications

References 3 publications

Assessment of agreement and interchangeability between the TEG5000 and TEG6S thromboelastography haemostasis analysers: a prospective validation study

Assessment of agreement and interchangeability between the TEG5000 and TEG6S thromboelastography haemostasis analysers: a prospective validation study

Assessing TEG6S reliability between devices and across multiple time points: A prospective thromboelastography validation study

Whole Blood Assay: Thromboelastometry – Basics

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