Coagulation Gene Predictors of Photodynamic Therapy for Occult Choroidal Neovascularization in Age-Related Macular Degeneration

Parmeggiani, Francesco; Costagliola, Ciro; Gemmati, Donato; D’Angelo, Stefano; Perri, Paolo; Campa, Claudio; Catozzi, Linda; Federici, Federica; Sebastiani, Adolfo; Incorvaia, Carlo

doi:10.1167/iovs.07-1654

Cited by 38 publications

(50 citation statements)

References 60 publications

(58 reference statements)

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“…Unlike many previous studies [10][11][12][13][14], we classified PDT responders and nonresponders based on objective findings including fundus photography, FA and OCT. The classifications between "PDT-responder" and "nonresponder" according with objective (anatomical) findings are also seen in recent publications [25,26].…”

Section: Discussionmentioning

confidence: 85%

Positive Association of Complement Factor H Gene Variants with the Effect of Photodynamic Therapy in Polypoidal Choroidal Vasculopathy

Bessho¹,

Honda²,

Kondo³

et al. 2011

J Clinic Experiment Ophthalmol

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Purpose: To clarify the association of complement factor H (CFH) gene polymorphisms with the effects of photodynamic therapy (PDT) in polypoidal choroidal vasculopathy (PCV).Methods: Ninety-three PCV subjects treated with PDT were recruited. Patients who showed anatomical success after the treatments with a single or two consecutive PDT sessions were classified as PDT responders. All others were classified as non-PDT responders. Three single nucleotide polymorphisms (SNPs), rs800292 (I62V), rs1061170 (Y402H) and rs1410996 were genotyped using the TaqMan assay. Results:The genotype and allelic frequency of rs1061170 (Y402H) and rs1410996 were significantly different between PDT responders and non-responders. In these SNPs, the risk alleles for PCV prevalence were beneficial for PDT response. In the time course analysis, the cases with C/C genotype in rs1410996 showed a significant increase of mean visual acuity at 6 and 12 months after the first PDT. Conclusions:The coding variants in CFH may be associated with the effects of PDT in PCV. genetic variations in the CFH region including Asian populations, and the association between these CFH variants and the ability of PDT to regress PCV in a Japanese population was analyzed.

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Section: Discussionmentioning

confidence: 85%

Positive Association of Complement Factor H Gene Variants with the Effect of Photodynamic Therapy in Polypoidal Choroidal Vasculopathy

Bessho¹,

Honda²,

Kondo³

et al. 2011

J Clinic Experiment Ophthalmol

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“…Of six gene polymorphisms genotyped, thrombophilic factor V G1691A, factor XIII-A G185T, methionine synthase A2756G, methionine synthase reductase A66G, methylenetetrahydrofolate reductase C677T and prothrombin G20210A, the latter two were identified to be more prevalent within responders. Hyperfibrinolytic factor XIII-A G185T was clearly overrepresented in the nonresponder fraction [176,177].…”

Section: Genetic Studiesmentioning

confidence: 91%

Platelets, photosensitizers, and PDT

Senge

Radomski

2013

Photodiagnosis and Photodynamic Therapy

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SummaryPhotodynamic therapy (PDT) has both direct cell and indirect vascular effects. Both are well established and the latter has given rise to specifically target angiogenesis in PDT treatments. While the vascular effects are well understood, further advances in antiangiogenesis require a detailed understanding of PDT effects at the microvasculature level. Although some of the earliest investigations of PDT noted effects on platelet aggregation the importance of their interaction with endothelial cells and the crucial role of various signaling pathways is only now emerging. This review aims to give a general overview of PDT related studies on platelets, vascular effects, and their interaction with endothelial cells to indicate the potential for studies in this area.Abbreviations: ALA --aminolevulinic acid; AMD -age-related macular degeneration; ANET -anti-neovascular therapy; BGF -basic fibroblast growth factor; DHEdihaematoporphyrin ether; EDRF -endothelium-derived relaxing factor; epithelial growth factor -EGF; HIF-1 -hypoxia-inducible factor 1; HpD -haematoporphyrin derivative; IL -interleukin; PAF -platelet activating factor; PDT -photodynamic therapy; PS -photosensitizer; transforming growth factor 1 -TGF-1; TNF -tumor necrosis factor.

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“…Variants in genes predisposing to hypercoagulability, including prothrombin 20210A and factor V 1691A alleles, have been associated with improved responses to therapy, and the C677T polymorphism in the gene for methylenetetrahydrofolate reductase associates with increased responses in classic CNV. 95,96 Rather unsurprisingly, variations predisposing to increased fibrinolysis, notably the G185T mutation of factor XIII-A, have been linked to nonresponse to treatment. 95,96 Dry Age-Related Macular Degeneration…”

Section: Photodynamic Therapymentioning

confidence: 99%

“…95,96 Rather unsurprisingly, variations predisposing to increased fibrinolysis, notably the G185T mutation of factor XIII-A, have been linked to nonresponse to treatment. 95,96 Dry Age-Related Macular Degeneration…”

Section: Photodynamic Therapymentioning

confidence: 99%

Genetics in Age-Related Macular Degeneration

Broadhead

Chang²,

McCluskey³

2012

Asia-Pacific Journal of Ophthalmology

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Age-related macular degeneration (AMD) remains a leading cause of visual loss in the developed world, and genetic factors are known risks for disease development, as well as affecting response to therapy. Here, we review genetic factors associated with AMD and the influence of genetics on the understanding of AMD pathogenesis. The potential role of genetics in assisting in the management of AMD and future research avenues are also discussed.

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Coagulation Gene Predictors of Photodynamic Therapy for Occult Choroidal Neovascularization in Age-Related Macular Degeneration

Abstract: These data provide evidence of the presence of a pharmacogenetic relationship between peculiar coagulation-balance genetic backgrounds and different levels of PDT-V effectiveness in patients with AMD with occult CNV.

Cited by 38 publications

References 60 publications

Positive Association of Complement Factor H Gene Variants with the Effect of Photodynamic Therapy in Polypoidal Choroidal Vasculopathy

Positive Association of Complement Factor H Gene Variants with the Effect of Photodynamic Therapy in Polypoidal Choroidal Vasculopathy

Platelets, photosensitizers, and PDT

Genetics in Age-Related Macular Degeneration

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