Coagulation factor levels and venous thrombosis in the black population

Patel, Raj; Ford, Elizabeth; Thumpston, Jill; Arya, Roopen

doi:10.1055/s-0037-1614274

Cited by 10 publications

(6 citation statements)

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“…In fact, racial differences in fibroid growth and severity have been recognized for a long time . As hypothesized, most women in our group had no identifiable thrombophilia except for high FVIII levels as previously reported in patients with similar ethnicity .…”

Section: Single Centre Experience Showing the Details Of The Thrombossupporting

confidence: 72%

Is there an Association between Thrombosis and Fibroids? A single centre experience and literature review

Riat

Chowdary

Mavrides

et al. 2012

Int J Lab Hematology

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Section: Single Centre Experience Showing the Details Of The Thrombossupporting

confidence: 72%

Is there an Association between Thrombosis and Fibroids? A single centre experience and literature review

Riat

Chowdary

Mavrides

et al. 2012

Int J Lab Hematology

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“…When compared with Whites, Blacks have higher levels of fibrinogen, [35,36,38] factor VIII, [37,38,44] von Willebrand factor [37,38,44], and plasma fibrin D-dimer [38,45,46], and lower levels of protein C [36]. Moreover, among Blacks, VTE has been associated with increased levels of fibrinogen, [29] factor VIII [47], and plasma fibrin D-dimer [48]. Although the lower prevalence of a family history of VTE among Blacks when compared with Whites might argue against a heritable component, this observation could also be explained by the frequent incomplete penetrance of inherited thrombophilia [14,[49][50][51].…”

Section: Discussionmentioning

confidence: 99%

Comparison of characteristics from White‐ and Black‐Americans with venous thromboembolism: A cross sectional study

Heit¹,

Beckman²,

Bockenstedt³

et al. 2010

American J Hematol

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have darker skin than White-Americans, they have lower serum D] levels, with mean value of 16 ng/mL compared with 26 ng/mL for White-Americans [2]. Lower serum 25(OH)D levels are a risk factor for cardiovascular disease in general [3] and venous thrombotic events in particular [4], as well as Type 2 diabetes mellitus [3]. A recent review concluded that the disparities in serum 25(OH)D levels can account for most of the 25% higher mortality rates for Black-Americans compared with White-Americans [5]. If Black-Americans were to supplement with 2,000-5,000 IU/day of vitamin D3, which would raise serum 25(OH)D levels from a mean value of 16 ng/mL to 30-50 ng/mL, they would significantly reduce their risk of venous thromboembolism, other cardiovascular diseases, Type 2 diabetes mellitus, many types of cancer, and a number of bacterial and infectious diseases [3,5]. Acute lymphoblastic leukemia in a patient with type 1 Gaucher disease developing 1 year after discontinuation of enzyme replacement therapy WILLIAM B. GRANTTo the editor: Gaucher disease (GD) is the commonest lysosomal storage disorder resulting because of the deficiency of an enzyme beta glucocerebrosidase. The progressive glucocerebroside accumulation in the macrophages provides a chronic antigenic stimulus to the immune system resulting in lymphoproliferation and impaired cellular immunity. This could lead to the pathogenesis of hematological malignancy; the mean age of presentation for which is reported to be 57 years [1]. Enzyme replacement therapy (ERT) is the standard of treatment in GD, but it is unknown if it has a role in mitigating cancer development. Our patient was a 31-year-old male with a family history of GD and was diagnosed to have type 1 GD at age 14. The patient had been relatively free from any significant complications associated with the disease. He presented

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“…Pieper et al (2000) tested d ‐dimer in older patients and found blacks to have a 40% higher d ‐dimer compared to age‐matched white subjects. A study in the UK black population found significantly higher d ‐dimer levels in those with DVT compared to healthy controls (Patel et al , 2004). Furthermore, d ‐dimer levels above the 90th centile of healthy controls were associated with a more than four‐fold increased risk of DVT.…”

Section: Biomarkers Associated With Vtementioning

confidence: 99%

“…Elevated d-dimer most likely reflects underlying activation of coagulation and fibrinolysis, rather than a direct causal link to VTE. Clustering of d-dimer, fibrinogen and factor VIII (FVIII), reported in healthy Europeans (Van Hylckama Vleig et al, 2003), was not demonstrable within the UK black population (Patel et al, 2004). Unless an ethnically appropriate reference range is determined, using d-dimer to stratify VTE recurrence risk could result in many black DVT patients being erroneously considered at high risk of recurrence and potentially treated with extended anticoagulation.…”

Section: D-dimermentioning

confidence: 99%

Venous thromboembolism and ethnicity

2009

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SummaryVenous thromboembolism (VTE) has long been considered a disease that affects predominantly white populations, a misconception resulting from a paucity of epidemiological data from non-Western countries, and the low incidence of hereditary thrombophilia in those of non-Caucasian background. Over the last decade, interest has grown in this area with the emergence of evidence that VTE is as prevalent, if not more so, in the black population and is also common in Asian groups. Much is still to be learned, as our current knowledge of hereditary thrombophilia and acquired risk factors do not fully explain the risk of VTE in non-Caucasian groups. This review summarises the current understanding of ethnic variation in VTE and highlights the need for further research in this area.

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Coagulation factor levels and venous thrombosis in the black population

Cited by 10 publications

References 0 publications

Is there an Association between Thrombosis and Fibroids? A single centre experience and literature review

Is there an Association between Thrombosis and Fibroids? A single centre experience and literature review

Comparison of characteristics from White‐ and Black‐Americans with venous thromboembolism: A cross sectional study

Venous thromboembolism and ethnicity

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