Venous thromboembolism and ethnicity

Roberts, Lara N.; Patel, Raj; Arya, Roopen

doi:10.1111/j.1365-2141.2009.07786.x

Cited by 82 publications

(75 citation statements)

References 123 publications

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“…In this study, 6.95% (40/575) of affected women and none of the healthy controls showed the presence of FVL mutation. The prevalence rates were lower than most other western studies due to differences in ethnic distributions of these genetic mutations in Asian populations [5,8,9]. Mutations in the FV gene excluding FV Leiden, particularly at the other cleavage sites of FV, Arg306 and Arg679 have the potential to contribute to the APCR phenotype.…”

Section: Discussionmentioning

confidence: 53%

Factors contributing to APC-resistance in women with recurrent spontaneous miscarriages: Indian perspective

Sharma¹,

Singh²,

Mahapatra³

et al. 2015

Blood Cells, Molecules, and Diseases

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Section: Discussionmentioning

confidence: 53%

Factors contributing to APC-resistance in women with recurrent spontaneous miscarriages: Indian perspective

Sharma¹,

Singh²,

Mahapatra³

et al. 2015

Blood Cells, Molecules, and Diseases

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“…Venous thromboembolism has been considered a disease affecting predominantly White populations 25. However, in recent years, many studies have been done among a small number of ethnic groups 26, 27, 28, 29, 30, 31, 32, 33, 34.…”

Section: Discussionmentioning

confidence: 99%

Immigration, region of origin, and the epidemiology of venous thromboembolism: A population‐based study

Lazo‐Langner

Liu

Shariff

et al. 2018

Research and Practice in Thrombosis and Haemostasis

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BackgroundVenous thromboembolism (VTE) epidemiology has been mainly studied in populations largely of European ancestry.ObjectivesTo assess the epidemiology of VTE in immigrants to Ontario, Canada.Patients/MethodsWe conducted a population‐based retrospective cohort study using linked health‐care and administrative databases. We included 1 195 791 immigrants to Ontario and 1 195 791 nonimmigrants, matched on age, sex, and place of residence. The main exposure was ethnicity according to world region of origin, using a previously validated algorithm. The main outcome was incident onset of VTE during the period of observation. Risk ratios (RR) were calculated using Poisson regression models.ResultsThe incidence rate (IR) of VTE was lower among immigrants (0.87 per 1000 PY; 95% confidence interval [CI] 0.85‐0.89) than nonimmigrants (1.59 per 1000 PY; 95% CI 1.56‐1.61). Age‐ and sex‐standardized IR were lower among East and South Asian immigrants. Compared to immigrants for predominantly White regions, age‐ and sex‐specific RRs were consistently lower for East Asian (0.18‐0.30) and South Asian (0.29‐0.75) immigrants. In contrast, the RRs of VTE among Black (0.38‐1.50), Latin American (0.29‐1.25), Arab/Middle Eastern (0.44‐1.08) and West Asian (0.31‐1.16) immigrants were not significantly different from White immigrants.ConclusionsIn Ontario, the incidence of VTE is lower among immigrants compared to nonimmigrants. East and South Asian immigrants have a lower risk of VTE compared to White immigrants.

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“…A racial component is also well characterized, with white and black patients at significantly higher risk than Asian and Hispanic patients. 49 The full risk conveyed by a history of first-degree relative with VTE is not fully explained by these known associations, suggesting that further genetic loci remain to be identified. 47 Although data concerning medical patients specifically are not available, in other patient populations the antithrombin III deficiency and protein C deficiency have proven most significantly predictive of VTE events.…”

Section: Inherent Thrombophiliamentioning

confidence: 99%