Coactivation of μ- and κ-Opioid Receptors May Mediate the Protective Effect of Testosterone on the Development of Temporomandibular Joint Nociception in Male Rats

Macedo, Cristina Gomes de; Fanton, Letícia Esmanhoto; Fischer, Luana; Tambeli, Cláudia Herrera

doi:10.11607/ofph.1298

Cited by 19 publications

(9 citation statements)

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“…In ovariectomized rats fluctuating plasma E2 levels from a bolus injection increased visceral sensitivity, but high steady state levels from implanted pellets did not 96 . In contrast, testosterone has consistently been shown to be anti-nociceptive in animals 4, 5, 35, 41, 62, 67 , and clinical studies suggest a protective/antinociceptive action of testosterone 3, 115 . In a recent study, it was reported that the protective effect of endogenous testosterone on the development of TMJ nociception in male rats was mediated by the activation of central opioid mechanisms 67 .…”

Section: Discussionmentioning

confidence: 99%

Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Hu²,

et al. 2018

The Journal of Pain

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SIVH is more robust in female rats. Estradiol facilitates whereas testosterone dampens the development of SIVH. This could partially explain the greater prevalence of certain chronic visceral pain conditions in women. An increase in spinal BDNF is concomitant with increased stress-induced pain. Pharmaceutical interventions targeting this molecule could provide promising alleviation of SIVH in women.

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Section: Discussionmentioning

confidence: 99%

Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Hu²,

et al. 2018

The Journal of Pain

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“…Recently, a possible role of the central opioid system in the protective effect of testosterone was described. After treatment with naloxone, gonadectomized male rats on testosterone replacement that received formalin TMJ injection presented increased behavioral response, while the opioid antagonist had no effect on gonadectomized animals without hormonal replacement [7]. Additional evidence of a relationship between androgens and opioid system supports this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…The observation that patients with temporomandibular chronic pain and low testosterone levels display higher pain expression indicates that this hormone may modulate pain [6, 7]. In male rats, testosterone presented an antinociceptive effect in models of inflammatory pain (carrageenan, formalin and Freud’s adjuvant) [7–10]. The mechanisms underlying such effects of sex hormones, however, are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Influence of androgenic blockade with flutamide on pain behaviour and expression of the genes that encode the NaV1.7 and NaV1.8 voltage-dependent sodium channels in a rat model of postoperative pain

et al. 2019

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Background Experimental studies suggest that testosterone reduces the nociceptive response after inflammatory and neuropathic stimuli, however the underlying mechanisms have not been fully elucidated. The aims of this study were to evaluate the effect of peripheral blockade of testosterone on pain behaviour and on expression levels of the genes that encode the NaV1.7 and NaV1.8 channels, in dorsal root ganglia in an acute postoperative pain model, as well as the influence of androgen blockade on the expression of these genes. Methods Postoperative pain was induced by a plantar incision and the study group received flutamide to block testosterone receptor. The animals were submitted to behavioural evaluation preoperatively, 2 h after incision, and on the 1st, 2nd, 3rd and 7th postoperative days. Von Frey test was used to evaluate paw withdrawal threshold after mechanical stimuli and the guarding pain test to assess spontaneous pain. The expression of the genes encoding the sodium channels at the dorsal root ganglia was determined by real time quantitative polymerase chain reaction. Results Animals treated with flutamide presented lower paw withdrawal threshold at the 1st, 2nd, 3rd, and 7th postoperative days. The guarding pain test showed significant decrease in the flutamide group at 2 h and on the 3rd and 7th postoperative days. No difference was detected between the study and control groups for the gene expression. Conclusions Our data suggest an antinociceptive effect of androgens following plantar incision. The expression of genes that encode voltage-gated sodium channels was not influenced by androgen blockade.

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“…In females, the resilience phenotype confers only a small protection to stress-induced muscle pain. Since sex hormones also play a role in neuropathic 8, 32, 63 and inflammatory 1, 6, 16, 35 pain, exploring the interaction between androgens and NH-induced resilience in preclinical models of these pain syndromes is an important future direction.…”

Section: Resultsmentioning

confidence: 99%

Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats

Álvarez

Green

Levine

2018

The Journal of Pain

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Coactivation of μ- and κ-Opioid Receptors May Mediate the Protective Effect of Testosterone on the Development of Temporomandibular Joint Nociception in Male Rats

Cited by 19 publications

References 0 publications

Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Influence of androgenic blockade with flutamide on pain behaviour and expression of the genes that encode the NaV1.7 and NaV1.8 voltage-dependent sodium channels in a rat model of postoperative pain

Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats

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