Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Ji, Yaping; Hu, Bo; Li, Jiyun; Traub, Richard J.

doi:10.1016/j.jpain.2018.02.007

Cited by 59 publications

(54 citation statements)

References 118 publications

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“…39 Visceral hypersensitivity induced by stress persisted several weeks in females but only a few days in males, and facilitated by orchiectomy and injection of E2 in males. 26 E2 replacement is an essential factor in increasing the expression of 5-HT 3A receptor in the spinal cord in this study, which is consistent with the observation that the development of somatic hyperalgesia in the E2 + FS group. However, repeated FS alone in this study also induced short period hyperalgesia in rats.…”

Section: Discussionsupporting

confidence: 92%

Spinal 5-HT₃receptor contributes to somatic hyperalgesia induced by sub-chronic stress

Yang

Tao

et al. 2019

Mol Pain

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Stress facilitates pain perception and sensitizes pain pathways, but the underlying mechanism is still unclear. The purpose of this study was to investigate whether the activation of 5-hydroxytryptamine (5-HT) subtype-3 receptor in the spinal cord contributes to somatic hyperalgesia induced by repeated three-day forced swim in the estradiol replacement rats after ovariectomy. Somatic sensitivity was assessed by thermal withdrawal latency to radiant heat and mechanical withdrawal threshold to von Frey filaments. The expression of 5-HT 3A receptor in the L4–L5 dorsal spinal cord was examined by Western blot. Repeated forced swim stress reduced the thermal withdrawal latency and mechanical withdrawal threshold, and the presence of estradiol exaggerated this hyperalgesia. The expression of 5-HT 3A receptor in the L4–L5 dorsal spinal cord increased significantly following repeated forced swim in estradiol replacement rats. Intrathecal injection of 5-HT 3 receptor antagonist Y-25130 blocked the somatic hyperalgesia induced by forced swim stress. These data indicate that 5-HT 3 receptor activation through the descending facilitation system contributes to the somatic hyperalgesia evoked by forced swim stress. The results may provide a new therapeutic avenue for alleviating pain induced by stress.

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Section: Discussionsupporting

confidence: 92%

Spinal 5-HT₃receptor contributes to somatic hyperalgesia induced by sub-chronic stress

Yang

Tao

et al. 2019

Mol Pain

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“…The reasons of these gender differences are not completely understood. Gonadal sex hormones such as estradiol seem to enhance sensitivity and pain perception . It is also shown that the menstrual cycle influences IBS symptom occurrence and severity .…”

Section: Discussionmentioning

confidence: 99%

Irritable bowel syndrome, mental health, and quality of life: Data from a population‐based survey in Germany (SHIP‐Trend‐0)

Schauer

Grabe

Ittermann

et al. 2018

Neurogastroenterology Motil

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Background Irritable bowel syndrome (IBS) is associated with reduced quality of life and high healthcare costs. This study aimed to assess the prevalence and risk factors for IBS in a general adult population. Methods The Study of Health in Pomerania (SHIP) is a population‐based cohort study in northeastern Germany. SHIP‐Trend‐0 participants enrolled from 2008 to 2012 were grouped according to Rome III criteria (main criteria: abdominal discomfort or crampy or bloating pain for at least six months plus 2/3 additional criteria). Factors associated with IBS were assessed using survey‐weighted backward stepwise logistic regression. Key Results The final data set included 4194 records. IBS prevalence was 3.5% (3.0%‐4.2%). Unemployment (OR: 2.02, 1.26‐3.21), headaches (OR: 2.37, 1.59‐3.52), mental quality of life (OR: 0.95 per unit increase, 0.93‐0.97), and interactions between gender and physical quality of life (P = 0.004) and gender and alexithymia (P = 0.002) predicted IBS probability. The model resulted in a good discrimination (area under the curve = 75.4%) and model fit (F = 0.72, P = 0.69). History of depression (OR: 2.77, 1.94‐3.95), back pain (OR: 2.38, 1.69‐3.35), early trauma (OR: 1.03, 1.02‐1.04), and duration of inpatient treatment within the last twelve months (OR: 1.02, 1.01‐1.04) lost their significance in multivariable analysis. Conclusions & Inferences IBS prevalence was relatively low compared to other studies. Factors predicting IBS were of biological, psychological, and social nature. The association between IBS and pain in different areas of the body indicates a potential underlying complex somatic symptom disorder.

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“…Previous studies in animals have shown that stress increases visceral sensitivity 7,16,22,31,32,46,57,70,71 . The visceromotor response (VMR) is a contraction of core muscles in response to hollow organ distension recorded as a change in magnitude of the abdominal muscle EMG.…”

Section: Introductionmentioning

confidence: 96%

“…It is generally accepted that colonic inflammation following intracolonic administration of exogenous substances (e.g., TNBS, mustard oil, capsaicin) increases the VMR in rats and mice to colorectal distension by sensitizing colonic afferents and visceroceptive dorsal horn neurons 29,33 . Likewise, neonatal stress or chronic stress in adults increases the magnitude of the VMR to visceral stimulation 15,16,31,32,47,57,60 . Stress activates the HPA axis and sympathomedullary axis increasing release of inflammatory mediators in the colon and altering corticotrophin releasing factor (CRF)/CRF receptor signaling, degranulation of mast cells and release of serotonin suggesting stress sensitizes colonic afferents and dorsal horn neurons contributing to visceral hypersensitivity 4,31,55,66 .…”

Section: Introductionmentioning

confidence: 99%

Differential Activation of Colonic Afferents and Dorsal Horn Neurons Underlie Stress-Induced and Comorbid Visceral Hypersensitivity in Female Rats

Cao

Yang

et al. 2021

The Journal of Pain

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Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Cited by 59 publications

References 118 publications

Spinal 5-HT₃receptor contributes to somatic hyperalgesia induced by sub-chronic stress

Spinal 5-HT₃receptor contributes to somatic hyperalgesia induced by sub-chronic stress

Irritable bowel syndrome, mental health, and quality of life: Data from a population‐based survey in Germany (SHIP‐Trend‐0)

Differential Activation of Colonic Afferents and Dorsal Horn Neurons Underlie Stress-Induced and Comorbid Visceral Hypersensitivity in Female Rats

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Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Cited by 59 publications

References 118 publications

Spinal 5-HT3receptor contributes to somatic hyperalgesia induced by sub-chronic stress

Spinal 5-HT3receptor contributes to somatic hyperalgesia induced by sub-chronic stress

Irritable bowel syndrome, mental health, and quality of life: Data from a population‐based survey in Germany (SHIP‐Trend‐0)

Differential Activation of Colonic Afferents and Dorsal Horn Neurons Underlie Stress-Induced and Comorbid Visceral Hypersensitivity in Female Rats

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Spinal 5-HT₃receptor contributes to somatic hyperalgesia induced by sub-chronic stress

Spinal 5-HT₃receptor contributes to somatic hyperalgesia induced by sub-chronic stress