Co(<scp>ii</scp>), Ni(<scp>ii</scp>) and Cu(<scp>ii</scp>) complexes with phenylthiazole and thiosemicarbazone-derived ligands: synthesis, structure and cytotoxic effects

Sobiesiak, Marta; Muzioł, Tadeusz; Różalski, Marcin; Krajewska, Urszula; Budzisz, Elżbieta

doi:10.1039/c4nj00977k

Cited by 35 publications

(19 citation statements)

References 39 publications

(33 reference statements)

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“…The 1 H NMR, 13 C NMR, IR spectrals data was obtained for all new complexes 2a-2d and new ligand 1b, while ligands 1a, 1c and 1d were prepared by methods described in literature. 20,23,24 The chemical shis and intensities are compatible with products obtained in the synthesis procedure. Aromatic protons of pcymene were seen in the range from 4.71 to 6.16 ppm as doublets.…”

Section: Characterization Of Ligand 1b and Half-sandwich Complexes 2a-2dmentioning

confidence: 85%

“…Ligands 1a, 1c and 1d were prepared with the use of methods described before. 20,23,24 The 1 H NMR and 13 C NMR spectra were registered in DMSO-d 6 (for all complexes) and CDCl 3 -d (for ligand 1b) using Bruker Avance III 600 MHz spectrometer. The IR spectra were recorded in KBr on the FTIR-8400S Shimadzu Spectrophotometer.…”

Section: Methodsmentioning

confidence: 99%

“…Synthesis of ligand 1-[amino(thioxo)methyl]-3,5-dimethyl-1Hpyrazole (1a), 1-[amino(thioxo)methyl]-5-hydroxy-3-phenyl-1Hpyrazole (1c) and 1-[amino(thioxo)methyl]-5-hydroxy-3-methyl-1H-pyrazole (1d) was executed as described before (Sobiesiak et al and Grazul et al) 20,23,24 with some modications.…”

Section: Synthetic Proceduresmentioning

confidence: 99%

“…The 3,5-diethyl-1H-pyrazole-1-carbothioamide was prepared according to literature. 20,23 Hydrazinocarbothioamide (1.25 g, 0.014 mol) was dissolved in 80 ml (0.2 M) hydrochloric acid solution. Next, heptane-2,4-dione was added to the stirred mixture.…”

Section: Synthetic Proceduresmentioning

confidence: 99%

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Anticancer and antimicrobial properties of novel η⁶-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization

et al. 2019

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Section: Characterization Of Ligand 1b and Half-sandwich Complexes 2a-2dmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Synthetic Proceduresmentioning

confidence: 99%

Section: Synthetic Proceduresmentioning

confidence: 99%

See 2 more Smart Citations

Anticancer and antimicrobial properties of novel η⁶-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization

et al. 2019

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“…In case of Co(II) complexes at higher temperature rapid spin lattice relaxation broadens lines [29]. The value for g||, g⊥ and giso are summarized in Table-2.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Antibacterial Investigation of Mn(II) and Co(II) Complexes of Schiffs Base Ligand

Tyagi

Chandra

2019

Asian J. Chem.

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The metal complexes of transition element derived from Schiffs base ligand widely studied as they are easily prepared, available, low cost materials, have tendency of complexation [1]. The Schiffs base compounds contains the >C=N-linkage which is generally formed by condensation reaction between amine and ketone or aldehyde [2]. From last decades, various applications like antifungal, anticancer, antioxidant, antiviral, antimalarial, anti-inflammotry and antibacterial activities were reported [3]. Schiffs bases generally used as the ligands, have strong tendency to coordinate with the main group metals and transition metals [4]. Metal complexes of Schiffs base stimulated a vigorous interest for the contributions as material [5-9], as they have various applications in the fundamental and the applied sciences [10-12] widely in coordination chemistry [13,14]. Synthesis of new ligand which have different properties and the novel reactivity was perhaps the most important step as the ligands have electron donor and electron acceptor properties, different structural functional groups [15]. Position of ligand in coordination sphere is a major factor of the different studies [16]. Complexes of the multi-donor ligands widely used as they are biological active substances [17]. Thiadiazole derivatives

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A pseudo trinuclear nickel–sodium complex containing tris(8‐methyl‐2‐oxo‐quinolidineamino ethylamine): Synthesis, spectral characterization, X‐ray crystallography and in vitro biological evaluations

Naveen

Pandiyan

Anu

et al. 2020

Applied Organom Chemis

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A new mixed nickel–sodium complex has been synthesized from Ni(ClO4)2 and tris(8‐methyl 2‐oxo‐quinolidine amino ethylamine) with a 1:1 molar ratio in methanol and has been characterized by various analytical, spectroscopy and X‐ray diffraction studies which confirmed an octahedral geometry around the nickel ion. Further, structural optimization of the complex was performed using DFT calculations. The ligand and complex were evaluated for their binding affinity with CT‐DNA and an intercalative type of binding interaction was proposed from the absorption and fluorescence titration experiments. Albumin binding interaction of the ligand and complex was determined by absorption, fluorescence and synchronous spectral techniques at room temperature, suggesting the static quenching mechanism of BSA with the compounds. Antioxidant studies revealed the radical scavenging potential of Ni(II) complex. The anticancer activity of the ligand and complex was probed via in vitro cytotoxicity against human breast (MCF7) and lung (A549) cancer cell lines by MTT assay. Further, cytological changes observed in acridine orange/ethidium bromide and DAPI staining methods validated the cytotoxic potential of the complex.

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Co(ii), Ni(ii) and Cu(ii) complexes with phenylthiazole and thiosemicarbazone-derived ligands: synthesis, structure and cytotoxic effects

Cited by 35 publications

References 39 publications

Anticancer and antimicrobial properties of novel η⁶-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization

Anticancer and antimicrobial properties of novel η⁶-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization

Synthesis and Antibacterial Investigation of Mn(II) and Co(II) Complexes of Schiffs Base Ligand

A pseudo trinuclear nickel–sodium complex containing tris(8‐methyl‐2‐oxo‐quinolidineamino ethylamine): Synthesis, spectral characterization, X‐ray crystallography and in vitro biological evaluations

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Co(ii), Ni(ii) and Cu(ii) complexes with phenylthiazole and thiosemicarbazone-derived ligands: synthesis, structure and cytotoxic effects

Cited by 35 publications

References 39 publications

Anticancer and antimicrobial properties of novel η6-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization

Anticancer and antimicrobial properties of novel η6-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization

Synthesis and Antibacterial Investigation of Mn(II) and Co(II) Complexes of Schiffs Base Ligand

A pseudo trinuclear nickel–sodium complex containing tris(8‐methyl‐2‐oxo‐quinolidineamino ethylamine): Synthesis, spectral characterization, X‐ray crystallography and in vitro biological evaluations

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Anticancer and antimicrobial properties of novel η⁶-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization

Anticancer and antimicrobial properties of novel η⁶-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization