Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome

Bayrami, Abolfazl; Shirdel, Arezoo; Mahmoudi, Fariba; Habibi‐Yangjeh, Aziz; Singh, Ramesh P.; Raman, Abdul Aziz Abdul

doi:10.1016/j.msec.2020.111351

Cited by 13 publications

(10 citation statements)

References 48 publications

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“…In another study, researchers loaded the Foeniculum vulgare Mill. extract on chitosan-engaged tripolyphosphate ions as a cross-linking molecule and found that this encapsulated formulation was better in controlling the symptoms of PCOS as compared to fennel-alone extract (Bayrami et al, 2020). 9.3.23 Ferula asafoetida (Falc.)…”

Section: Foeniculum Vulgare Mill [Apiaceae]mentioning

confidence: 99%

Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies

et al. 2022

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Polycystic ovary syndrome (PCOS) is a very common, complex, and heterogeneous endocrine disorder of women that involves a combination of environmental and genetic factors. PCOS affects women of growing age particularly at the early to late reproductive stage (15–35 years). Currently, PCOS affects 1 in every 10 women worldwide. It is characterized majorly by a raised level of androgens such as testosterone and a large number of ovarian cysts (more than 10) that cause anovulation, infertility, and irregular menstrual cycle. PCOS is also related to other endocrine and metabolic abnormalities, such as obesity, hirsutism, acne, diabetes, insulin resistance, and glucose impairment. PCOS can be treated with allopathic, ayurvedic, and natural or herbal medications along with lifestyle modifications. Herbal medicines remained in demand for numerous reasons such as high cost and side effects associated with the use of allopathic medicine and our traditional norms, which have helped humans to use more herbal products for their health benefits. Estrogenic and nonestrogenic phytochemicals present in various plant species such as Glycyrrhiza glabra L. [Fabaceae], Aloe vera (L.) Burm. f. [Asphodelaceae], Silybum marianum (L.). Gaertn. [Asteraceae], Serenoa repens (W.Bartram) Small [Arecaceae], Actaea racemosa L. [Ranunculaceae], and Angelica sinensis (Oliv.) Diels [Apiaceae] are effective and harmless. Herbal medicines are found to be cost-effective, efficacious, and a highly esteemed source of management/treatment for PCOS than allopathic medicines. In this literature review, diagnosis, signs, and symptoms of PCOS; causes of hormonal imbalance; and risk factors associated with PCOS and their management are discussed briefly, and the focus was to find out the role of herbal remedies in PCOS management.

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Section: Foeniculum Vulgare Mill [Apiaceae]mentioning

confidence: 99%

Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies

et al. 2022

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“…Particle size, polydispersity index, and zeta potential measurements. The dynamic light scattering method was used to measure the mean size and polydispersity index (PDI) of NPs [35], and the electrophoretic light scattering method was used to determine the zeta potential of NPs, and these measurements were performed using the Zetasizer (Zetasizer Nano ZS, Malvern, UK) instrument [36]. Measurements were carried out in triplicate, automatically, at 25 °C ± 0.1 °C with using 0.8872 cP of viscosity and 1.330 of refractive index for the solutions.…”

Section: Preparation Of Ktz-loaded Plga Npsmentioning

confidence: 99%

Ketoconazole-loading strategy to improve antifungal activity and overcome cytotoxicity on human renal proximal tubular epithelial cells

Coksu,

Bozkurt,

Akmayan

et al. 2023

Nanotechnology

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Ketoconazole (KTZ), an antifungal agent used to treat localized or systemic fungal infections by inhibiting ergosterol synthesis, exhibits restricted efficacy within eukaryotic cells owing to its elevated toxicity and limited solubility in water. This study aims to improve the biological activity and overcome cytotoxic effects in the renal system of the hydrophobic KTZ by incorporating it into poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) utilizing biomaterial nano-engineering techniques. KTZ-loaded PLGA NPs (KTZ-NPs) were prepared by single emulsion solvent evaporation method and characterized by using dynamic light scattering (DLS), electrophoretic light scattering (ELS), Fourier transform-infrared (FT-IR) spectroscopy and scanning light microscopy (SEM). Particle size and zeta potential of KTZ-NPs were determined as 182.0 ± 3.27 nm and −27.4 ± 0.56 mV, respectively. Antifungal activity was analyzed with the time-kill and top agar dilution methods on Candida albicans (C. albicans) and Aspergillus flavus (A. flavus). Both KTZ and KTZ-NPs caused a significant decrease in A. flavus cell growth; however, the same effect was only observed in time-killing analysis on C. albicans, indicating a methodological difference in the antifungal analysis. According to the top agar method, the MIC value of KTZ-NPs against A. flavus was 9.1 μg ml−1, while the minimum inhibition concentration (MIC) value of KTZ was 18.2 μg ml−1. The twofold increased antifungal activity indicates that nanoparticular drug delivery systems enhance the water solubility of hydrophobic drugs. In addition, KTZ-NPs were not cytotoxic on human renal proximal tubular epithelial cells (HRPTEpCs) at fungistatic concentration, thus reducing fungal colonization without cytotoxic on renal excretion system cells.

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“… Reduced cystic follicles. Improvement of folliculogenesis and regulation of gonadotropins synthesis [ 62 ] Plant Majoram extract Origanum majorana Wistar rats 20 mg/kg/day; 24 days Beneficial ameliorative effects against PCOS ↑SOD, GPx ↓IL-6 [ 63 ] Plant Pergularia daemia ethanol extract Pergularia daemia Wistar rats 300 mg/kg/day; 28 days Improvement of ovulation and menstrual irregularity ↓follicle-stimulating hormone, progesterone [ 61 ] Plant Chitosan-engaged tripolyphosphate ions and concurrent loading of the biomolecules of the ethanolic extract of fennel seed Foeniculum vulgare Wistar rats 50 mg/kg/day; 15 days Regulation of the hormonal and biochemical changes of PCOS ↑FSH, HDL ↓Insulin, LH, FBS, [ 58 ] Decoction Combination of Gymnema sylvestre, Pergularia daemia ethanol extract Gymnema sylvestre, Pergularia daemia Wistar rats 400 mg/kg/day; 28 days Synergistic effects against PCOS ↑Luteinizing hormone, testosterone, estrogen [ 61 ] Plant Actaea racemosa and Vitamin C Cimicifuga racemosa Wistar rats AR extract 7.14 mg/kg, vitamin C 500 mg/kg; 28days Alleviation of PCOS without hepatic adverse effect ↑GSH, Ki-67, Cyp19a1 ↓MDA [ ...…”

Section: The Promising Evidence Of Natural Products In Modern Drug Di...mentioning

confidence: 99%

Effects of natural products on polycystic ovary syndrome: From traditional medicine to modern drug discovery

Jung,

Choi,

Kim

et al. 2023

Heliyon

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Co-regulative effects of chitosan-fennel seed extract system on the hormonal and biochemical factors involved in the polycystic ovarian syndrome

Cited by 13 publications

References 48 publications

Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies

Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies

Ketoconazole-loading strategy to improve antifungal activity and overcome cytotoxicity on human renal proximal tubular epithelial cells

Effects of natural products on polycystic ovary syndrome: From traditional medicine to modern drug discovery

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