Co-phenylcaine as an alternative to Brompton's solution in rigid nasendoscopy: a pilot study

Abstract

There was no difference between the two agents with regard to nasal analgesia and vasoconstriction during rigid nasal endoscopy.

Assessing the safety and efficacy of drugs used in preparing the nose for diagnostic and therapeutic procedures: a systematic review

“…However, preparations such as co‐phenylcaine, which contain lignocaine and phenylephrine as its active constituents, have been trialled as safer, more easily administered alternatives in nasendoscopy applied 10 min pre‐op . Numerous studies have shown co‐phenylcaine to be as effective as cocaine and often more tolerable for flexible/rigid nasendoscopy, nasogastric tube insertion and in flexible bronchoscopy …”

A double‐blind randomised controlled trial assessing the efficacy of topical lidocaine in extended flexible endoscopic nasal examinations

“…In addition to this, it is unclear if the results would be similar if a rigid endoscopic examination was performed. Previous studies assessing the rigid endoscopic examination demonstrate similar levels of discomfort compared with flexible endoscopic nasal examinations 15–17 . However, these studies assessing the rigid endoscope contain many of the confounding variables present in studies assessing flexible examinations.…”

Topical anaesthesia before nasendoscopy: a randomized controlled trial of co‐phenylcaine compared with lignocaine

“…Because of the sensitivity of the nasal mucosa it is common practice for this procedure to be performed after the application of topical anaesthesia. Several studies have compared the efficacy of different topical agents used during outpatient nasendoscopy performed with either rigid or flexible nasendoscopes 1–3 . These studies have not found any difference between the efficacy of cocaine, lignocaine and co‐phenylcaine (lignocaine 5% and phenylephrine 0.5% in combination) regarding either the discomfort experienced by the patient or the ease of obtaining an adequate view.…”