Co-occurrence of decrements in physical and cognitive function is common in older oncology patients receiving chemotherapy

Utne, Inger; Cooper, Bruce A.; Ritchie, Christine S.; Wong, Melisa L.; Dunn, Laura B.; Løyland, Borghild; Grov, Ellen Karine; Hammer, Marilyn J.; Paul, Steven M.; Levine, Jon D.; Conley, Yvette P.; Kober, Kord M.; Miaskowski, Christine

doi:10.1016/j.ejon.2020.101823

Cited by 5 publications

(2 citation statements)

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“…59 Of note, although neither the subjective nor objective measures of physical function were associated with changes in cognitive function, in a previous study of older breast cancer patients, 12 higher levels physical function decreased the odds of long-term cognitive decline and that an accelerated cognitive decline was associated with decrements of physical function. In addition, in our previous study with a different sample, 63 more than 50% of the older patients had decrements in physical and cognitive function over 2 cycles of chemotherapy. Given our relatively small sample size and the known associations between physical and cognitive function, 22,23,25,27,28 future studies with larger samples need to evaluate the relative contribution of physical function to changes in cognitive function in older oncology patients.…”

Section: Discussionmentioning

confidence: 76%

Changes in Subjective Measures of Cognitive Function in Older Adults From the Initiation Through 12 Months After the Receipt of Chemotherapy

et al. 2022

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Background Cognitive impairment has a negative impact on older patients with cancer. Objectives The aim of this study was to evaluate for interindividual differences in 2 subjective measures of cognitive function in older patients (n = 112), as well as determine which demographic, clinical, and symptom characteristics, and levels of physical function, were associated with initial levels and with the trajectory of each of these 2 measures. Methods Cognitive function was assessed using the cognitive function scale from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the Attentional Function Index at the initiation of chemotherapy and at 1, 3, 6, 9, and 12 months after its initiation. Hierarchical linear modeling was used to assess for interindividual differences in and characteristics associated with initial levels and changes in cognitive function. Results Characteristics associated with decreases in Quality of Life Questionnaire Core 30 scores at the initiation of chemotherapy were longer time since the cancer diagnosis and higher depression scores. Characteristics associated with poorer Attentional Function Index scores at enrollment were lower levels of education and higher depression scores. No characteristics were associated with worse trajectories of either cognitive function measure. Conclusion Some older patients undergoing chemotherapy experience decrements in cognitive function. Implications for Practice Our findings suggest that clinicians need to assess for depressive symptoms in older patients before the initiation of chemotherapy. Evidence-based interventions (eg, cognitive stimulation, increased physical activity) can be recommended to maintain and increase cognitive function in older oncology patients.

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Section: Discussionmentioning

confidence: 76%

Changes in Subjective Measures of Cognitive Function in Older Adults From the Initiation Through 12 Months After the Receipt of Chemotherapy

et al. 2022

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“…While the exact relationships between various brain functions and gait are not well understood, research suggests that higher levels of CF and memory are needed to organize mobility [41]. In addition, a prior study of older adults found associations between CF and PF [42]. As noted in one review [41], compared to other age-related changes, a decrease in gray matter had the strongest association with poorer gait.…”

Section: Discussionmentioning

confidence: 95%

Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy

Torstveit

Miaskowski

Løyland

et al. 2022

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Purpose Study purposes were to evaluate for inter-individual variability in the trajectories of three objective measures of physical function (PF) in older patients receiving chemotherapy (n = 112) and determine which characteristics were associated with worse PF. Methods Balance, gait speed, and chair-stand test were evaluated at initiation and 1, 3, 6, 9, and 12 months following chemotherapy. Hierarchical linear modeling was used to assess inter-individual variability in the trajectories of the three tests. Demographic, clinical, and symptom characteristics, and levels of cognitive function associated with initial levels and changes over time in each of the tests were determined. Results Gait speed and chair-stand tests improved over time. Balance declined until month 6, then increased. Characteristics associated with decreases in balance scores at initiation of chemotherapy were lower level of education and lower Karnofsky Performance Status (KPS) score. For initial levels of poorer gait speed, older age, poorer Trail Making Test B (TMTB), and worse Attentional Function Index scores were the associated characteristics. Lower KPS scores, higher body mass index, and poorer TMTB scores were associated with poorer chair-stand times at initiation of chemotherapy. Worse trajectories of chair-stand times were associated with poorer chair-stand time at enrollment. Characteristic associated with lower initial levels and improved trajectories of balance was older age at enrollment. Conclusions Determination of characteristics associated with decrements in balance, gait speed, and chair-stand can assist clinicians to identify older oncology patients at risk for decrements in PF. Interventions to maintain and improve PF need to be implemented with higher risk patients.

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Common and distinct characteristics associated with self-reported functional status in older patients with cancer receiving chemotherapy

Torstveit

Miaskowski

Løyland

et al. 2021

European Journal of Oncology Nursing

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Co-occurrence of decrements in physical and cognitive function is common in older oncology patients receiving chemotherapy

Cited by 5 publications

References 75 publications

Changes in Subjective Measures of Cognitive Function in Older Adults From the Initiation Through 12 Months After the Receipt of Chemotherapy

Changes in Subjective Measures of Cognitive Function in Older Adults From the Initiation Through 12 Months After the Receipt of Chemotherapy

Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy

Common and distinct characteristics associated with self-reported functional status in older patients with cancer receiving chemotherapy

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