Common and distinct characteristics associated with self-reported functional status in older patients with cancer receiving chemotherapy

Torstveit, Ann Helen; Miaskowski, Christine; Løyland, Borghild; Grov, Ellen Karine; Guren, Marianne Grønlie; Ritchie, Christine S.; Paul, Steven M.; Kleven, Anne Grethe; Utne, Inger

doi:10.1016/j.ejon.2021.102033

Cited by 5 publications

(5 citation statements)

References 72 publications

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“…As reported [25], patients (n = 112) were 70.4 (± 6.5) years of age, well-educated, and diagnosed with gynecological (90.2%) or colorectal (9.8%) cancer. Most patients were female (93.8%), married (64.3%), and not employed (83.0%).…”

Section: Patient Characteristicsmentioning

confidence: 85%

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Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy

Torstveit

Miaskowski

Løyland

et al. 2022

Support Care Cancer

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Purpose Study purposes were to evaluate for inter-individual variability in the trajectories of three objective measures of physical function (PF) in older patients receiving chemotherapy (n = 112) and determine which characteristics were associated with worse PF. Methods Balance, gait speed, and chair-stand test were evaluated at initiation and 1, 3, 6, 9, and 12 months following chemotherapy. Hierarchical linear modeling was used to assess inter-individual variability in the trajectories of the three tests. Demographic, clinical, and symptom characteristics, and levels of cognitive function associated with initial levels and changes over time in each of the tests were determined. Results Gait speed and chair-stand tests improved over time. Balance declined until month 6, then increased. Characteristics associated with decreases in balance scores at initiation of chemotherapy were lower level of education and lower Karnofsky Performance Status (KPS) score. For initial levels of poorer gait speed, older age, poorer Trail Making Test B (TMTB), and worse Attentional Function Index scores were the associated characteristics. Lower KPS scores, higher body mass index, and poorer TMTB scores were associated with poorer chair-stand times at initiation of chemotherapy. Worse trajectories of chair-stand times were associated with poorer chair-stand time at enrollment. Characteristic associated with lower initial levels and improved trajectories of balance was older age at enrollment. Conclusions Determination of characteristics associated with decrements in balance, gait speed, and chair-stand can assist clinicians to identify older oncology patients at risk for decrements in PF. Interventions to maintain and improve PF need to be implemented with higher risk patients.

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Section: Patient Characteristicsmentioning

confidence: 85%

“…A detailed description of the methods is presented in Appendix A and in previous publications [24,25].…”

Section: Methodsmentioning

confidence: 99%

Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy

Torstveit

Miaskowski

Løyland

et al. 2022

Support Care Cancer

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“…As described in our previous publication, 47 the demographic and clinical characteristics, as well as the symptom severity scores and scores for the measures of physical function for the sample (n = 112), are summarized in Table 1. Patients were 70.4 (±6.5) years old, well educated (83.9% high school or higher), and given a diagnosis of either gynecological (90.2%) or colorectal (9.8%) cancer.…”

Section: Resultsmentioning

confidence: 99%

“…As described in our previous publication, 47 the demographic and clinical characteristics, as well as the symptom severity scores and scores for the measures of physical function for the sample (n = 112), are summarized in Table 1. Patients were 70.4 On average, the patients were 1.3 (±3.9) years from their cancer diagnosis, had metastatic disease (78.6%), and had surgery before chemotherapy (54.5%).…”

Section: Patient Characteristicsmentioning

confidence: 99%

Changes in Subjective Measures of Cognitive Function in Older Adults From the Initiation Through 12 Months After the Receipt of Chemotherapy

et al. 2022

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Background Cognitive impairment has a negative impact on older patients with cancer. Objectives The aim of this study was to evaluate for interindividual differences in 2 subjective measures of cognitive function in older patients (n = 112), as well as determine which demographic, clinical, and symptom characteristics, and levels of physical function, were associated with initial levels and with the trajectory of each of these 2 measures. Methods Cognitive function was assessed using the cognitive function scale from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the Attentional Function Index at the initiation of chemotherapy and at 1, 3, 6, 9, and 12 months after its initiation. Hierarchical linear modeling was used to assess for interindividual differences in and characteristics associated with initial levels and changes in cognitive function. Results Characteristics associated with decreases in Quality of Life Questionnaire Core 30 scores at the initiation of chemotherapy were longer time since the cancer diagnosis and higher depression scores. Characteristics associated with poorer Attentional Function Index scores at enrollment were lower levels of education and higher depression scores. No characteristics were associated with worse trajectories of either cognitive function measure. Conclusion Some older patients undergoing chemotherapy experience decrements in cognitive function. Implications for Practice Our findings suggest that clinicians need to assess for depressive symptoms in older patients before the initiation of chemotherapy. Evidence-based interventions (eg, cognitive stimulation, increased physical activity) can be recommended to maintain and increase cognitive function in older oncology patients.

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“…Considering the chronic and debilitating nature of cancer, greater healthcare service utilisation, including emergency department visits and inpatient hospitalisations, is a significant contributor to the growing costs of cancer care [ 83 , 84 ]. Research should assess interventions capable of minimising the negative individual and health service-related costs; moreover, the need to investigate the impact of nursing care on functional status is also important, given that older cancer patients often have comorbidities, and they are more vulnerable to functional impairments during chemotherapy [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

What Nursing-Sensitive Outcomes Have Been Investigated to Date among Patients with Solid and Hematological Malignancies? A Scoping Review

Visintini

Palese

2023

Nursing Reports

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Nursing-sensitive outcomes are those outcomes attributable to nursing care. To date three main reviews have summarized the evidence available regarding the nursing outcomes in onco-haematological care. Updating the existing reviews was the main intent of this study; specifically, the aim was to map the state of the art of the science in the field of oncology nursing-sensitive outcomes and to summarise outcomes and metrics documented as being influenced by nursing care. A scoping review was conducted in 2021. The MEDLINE, Cumulative Index to Nursing and Allied Health, Web of Science, and Scopus databases were examined. Qualitative and quantitative primary and secondary studies concerning patients with solid/haematological malignancies, cared for in any setting, published in English, and from any time were all included. Both inductive and deductive approaches were used to analyse the data extracted from the studies. Sixty studies have been included, mostly primary (n = 57, 95.0%) with a quasi- or experimental approach (n = 26, 55.3%), conducted among Europe (n = 27, 45.0%), in hospitals and clinical wards (n = 29, 48.3%), and including from 8 to 4615 patients. In the inductive analysis, there emerged 151 outcomes grouped into 38 categories, with the top category being ‘Satisfaction and perception of nursing care received’ (n = 32, 21.2%). Outcome measurement systems included mainly self-report questionnaires (n = 89, 66.9%). In the deductive analysis, according to the Oncology Nursing Society 2004 classification, the ‘Symptom control and management’ domain was the most investigated (n = 44, 29.1%); however, the majority (n = 50, 33.1%) of nursing-sensitive outcomes that emerged were not includible in the available framework. Continuing to map nursing outcomes may be useful for clinicians, managers, educators, and researchers in establishing the endpoints of their practice. The ample number of instruments and metrics that emerged suggests the need for more development of homogeneous assessment systems allowing comparison across health issues, settings, and countries.

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Common and distinct characteristics associated with self-reported functional status in older patients with cancer receiving chemotherapy

Cited by 5 publications

References 72 publications

Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy

Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy

Changes in Subjective Measures of Cognitive Function in Older Adults From the Initiation Through 12 Months After the Receipt of Chemotherapy

What Nursing-Sensitive Outcomes Have Been Investigated to Date among Patients with Solid and Hematological Malignancies? A Scoping Review

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