2010
DOI: 10.3233/jad-2010-1333
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Co-Localization of Reelin and Proteolytic AβPP Fragments in Hippocampal Plaques in Aged Wild-Type Mice

Abstract: Reelin is a large extracellular glycoprotein required for proper neuronal positioning during development. In the adult brain, Reelin plays a crucial modulatory role in the induction of synaptic plasticity and successful formation of long-term memory. Recently, alterations in Reelin-mediated signaling have been suggested to contribute to neuronal dysfunction associated with Alzheimer's disease (AD). We previously reported that aging in several species is characterized by a decline in Reelin-expressing interneur… Show more

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Cited by 38 publications
(53 citation statements)
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“…Given that we found that they do not stain with Thioflavin S or with Hylite-AF488, and that Aβ-staining is a mistake due to the presence of the contaminant IgM, we conclude that there is no deposition of Aβ in these granular structures. It should be noted that Doehner et al (2010) reported that these granules stained with Thioflavin S, but we did not observe this positivity either in granules from SAMP8 mice or in those from APP/PS1 mice. In the latter, amyloid plaques were used as a positive control for Thioflavin S staining.…”
Section: Discussioncontrasting
confidence: 90%
“…Given that we found that they do not stain with Thioflavin S or with Hylite-AF488, and that Aβ-staining is a mistake due to the presence of the contaminant IgM, we conclude that there is no deposition of Aβ in these granular structures. It should be noted that Doehner et al (2010) reported that these granules stained with Thioflavin S, but we did not observe this positivity either in granules from SAMP8 mice or in those from APP/PS1 mice. In the latter, amyloid plaques were used as a positive control for Thioflavin S staining.…”
Section: Discussioncontrasting
confidence: 90%
“…We have reported in aged rodents and nonhuman primates a pronounced reduction of Reelin-expressing interneurons and concomitant accumulation of Reelin in amyloid-like deposits, colocalizing with proteolytic APP fragments and associated with a reduction in basal forebrain projection neurons that selectively target Reelin-positive hippocampal interneurons Madhusudan et al, 2009;Doehner et al, 2010). The course and magnitude of the plaque load correlated with cognitive performance and was modulated by exacerbated inflammatory responses and genetic mutations favoring A␤ peptide production ).…”
Section: Introductionmentioning
confidence: 98%
“…A 15 min pepsin pretreatment (0.15 mg/ml in 0.2N HCl at 37°C) was applied to all the free-floating sections for epitope unmasking and reduction of nonspecific staining (Doehner et al, 2010). Sections were then briefly washed with PBS, pH 7.4, and processed for immunohistochemistry.…”
Section: Methodsmentioning
confidence: 99%
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“…Abnormal tau expression and hyperphosphorylation are common features in AD and DS (Khatoon et al, 1994;Oyama et al, 1994), causing abnormalities in the cytoskeleton. In addition, increases in tau expression have been reported in other mouse models of AD and aging (Manich et al, 2011;Doehner et al, 2010;Madhusudan et al, 2009). …”
Section: Accepted Manuscriptmentioning
confidence: 99%