2010
DOI: 10.1523/jneurosci.0418-10.2010
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Reduced Reelin Expression Accelerates Amyloid-  Plaque Formation and Tau Pathology in Transgenic Alzheimer's Disease Mice

Abstract: In addition to the fundamental role of the extracellular glycoprotein Reelin in neuronal development and adult synaptic plasticity, alterations in Reelin-mediated signaling have been suggested to contribute to neuronal dysfunction associated with Alzheimer's disease (AD). In vitro data revealed a biochemical link between Reelin-mediated signaling, Tau phosphorylation, and amyloid precursor protein (APP) processing. To directly address the role of Reelin in amyloid-␤ plaque and Tau pathology in vivo, we crossed… Show more

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Cited by 111 publications
(121 citation statements)
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“…In agreement with these in vitro findings, genetically reduced Reelin levels in APP swe,arc mice increased the production of Aβ peptide and significantly aggravated the plaque pathology (Kocherhans et al, 2010). Moreover, Reelin reduction in these mice, expressing endogenous mouse Tau protein, induced the formation of PHF-like accumulations in the vicinity of the plaques (Kocherhans et al, 2010).…”
Section: Dysfunctional Reelin Signaling and Its Role In Ad Etiologysupporting
confidence: 68%
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“…In agreement with these in vitro findings, genetically reduced Reelin levels in APP swe,arc mice increased the production of Aβ peptide and significantly aggravated the plaque pathology (Kocherhans et al, 2010). Moreover, Reelin reduction in these mice, expressing endogenous mouse Tau protein, induced the formation of PHF-like accumulations in the vicinity of the plaques (Kocherhans et al, 2010).…”
Section: Dysfunctional Reelin Signaling and Its Role In Ad Etiologysupporting
confidence: 68%
“…While its expression during brain development is largely restricted to CajalRetzius cells in the marginal zone, Reelin expression in the adult brain is confined to olfactory and limbic pathways (Fig. 1C), where it modulates spine dynamics and synaptic plasticity, as well as suppresses Tau hyperphosphorylation (Herz and Chen, 2006, Forster et al, 2010, Knuesel, 2010. As documented previously (Alcantara et al, 1998, Martinez-Cerdeno et al, 2002, Ramos-Moreno et al, 2006, Reelin is expressed by granule, mitral and tufted cells of the olfactory bulb.…”
Section: Reelin Expression Within Olfactory-limbic Pathwaysmentioning
confidence: 57%
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“…Importantly, ApoE4 strongly interferes with these synapse-enhancing functions of Reelin by sequestering ApoE receptors in intracellular compartments (Chen et al 2010) (Fig. 3), thus providing a novel mechanism by which accelerated spine loss, increased tau phosphorylation (Kocherhans et al 2010), loss of network homeostasis Palop and Mucke 2010), and earlier disease onset through loss of neuroprotective compensatory bandwidth (Korwek et al 2009) can be readily explained. This mechanism is also consistent with the finding that ApoE4 reduces spine density and dendritic complexity in cortical neurons in vivo (Dumanis et al 2009).…”
Section: Apoe Receptors As Antagonists Of Ab-induced Synaptic Suppresmentioning
confidence: 99%