Co-interventions withClostridium butyricumand soluble dietary fiber targeting the gut microbiota improve MAFLDviathe Acly/Nrf2/NF-κB signaling pathway

Abstract

Purpose: The pathogenesis of metabolic associated fatty liver disease (MAFLD) is complex. The lipid metabolic disorder, chronic inflammation, and oxidative stress are the core events for MAFLD. Dietary intervention is...

Inverse relationship between dietary fiber intake and environmental exposure to acrylamide

“…Second, epidemiological study showed that acrylamide exposure was positively associated with systemic in ammatory mediator plasma C-reactive protein. Animal experiments demonstrated that dietary ber mediated oxidation by activating the Acly/Nrf2/NF-κB signaling pathway, which exerted antiin ammatory effects by inhibiting the differentiation of macrophages into pro-in ammatory M1 macrophages (Shao et al 2022). Thus, it is plausible to consider that the pathogenesis of dietary ber may be related to decreased concentrations of AA hemoglobin biomarkers's through its anti-in ammatory effects.…”

Perillartine protects against metabolic associated fatty liver in high-fat diet-induced obese mice

“…To further investigate the effects of perillartine on fat accumulation in vivo, mice were fed a normal diet or a high-fat diet supplemented with perillartine, with normal and high-fat diets serving as controls. [25][26][27] Compared with the high-fat diet, which showed rapid weight gain, the addition of perillartine could slow down the rate of weight gain in a dose-dependent manner, and there was a significant difference in body weight between the groups after 6 weeks of the high-fat diet. However, no difference in body weight was observed between the three groups given the normal diet (Fig.…”

Crosstalk between liver macrophages and gut microbiota: An important component of inflammation-associated liver diseases

“…The microbial metabolite, indole-3-acetic acid (I3A), which is elevated after sleeve gastrostomy, was found to promote M2 differentiation both in vivo and in vitro , relieving obesity-associated NAFLD ( Wang Y. et al, 2021 ). Further, coadministration of Clostridium butyricum and soluble dietary fiber reduced the percentage of KCs and the activation of M1 macrophages in liver by suppressing the TLR4/NF-κB signaling ( Shao et al, 2022 ).…”

“…In general, KCs are responsible for sensing and processing biochemical signals, such as pathogen components, cell fragments, and endo/exogenous metabolites (Diehl et al, 2020;Li W. et al, 2022). They can trigger primary inflammation and secrete chemokines to recruit MoMφs for further inflammatory responses (Wen et al, 2021;Zhou J. et al, 2022). Hepatic macrophages can also regulate inflammatory responses when stimulated with anti-inflammatory factors.…”

“…Reduces obesity-associated liver inflammation Moya-Perez et al (2015)Clostridium butyricum (plusing soluble dietary fiber)Decreases the percentage of KCs and the activation of M1 macrophages in liver with inhibited TLR4/NF-κB signaling pathway. Alleviates liver inflammation in NAFLD miceShao et al (2022) Pediococcus pentosaceus CGMCC 7049 Decreases and monocytes/macrophages related MIP-1 and MCP-1. Improves SCFAs production and liver inflammation in ALD.…”