Co-infection with <i>Anaplasma platys, Bartonella henselae, Bartonella koehlerae</i> and ‘<i>Candidatus</i> Mycoplasma haemominutum’ in a cat diagnosed with splenic plasmacytosis and multiple myeloma

Qurollo, Barbara A.; Balakrishnan, N.; Cannon, Coralie Zegre; Maggi, Ricardo G.; Breitschwerdt, Edward B.

doi:10.1177/1098612x13519632

Cited by 32 publications

(25 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, further investigation with additional phylogeny and amplification of multiple and longer genes are needed, in order to definitively prove the identity of this pathogen. In this case, as well as in the previous feline case reports [56, 57], the pathogenic role of A. platys in cats is not clear.…”

Section: Discussionmentioning

confidence: 49%

See 1 more Smart Citation

Prevalence study and risk factor analysis of selected bacterial, protozoal and viral, including vector-borne, pathogens in cats from Cyprus

et al. 2017

View full text Add to dashboard Cite

BackgroundFeline infectious agent studies are lacking in Cyprus. The aims of this study were to determine the prevalence and risk factors for various feline infectious agents, including feline vector-borne pathogens (FVBP), in cats from Cyprus.MethodsA cross-sectional, descriptive, multicentre study was performed on 174 feline samples [138 owned and 36 shelter-feral, including both healthy (43) and non-healthy (131), cats] from private veterinary clinics from all six districts of Cyprus. Real-time quantitative polymerase chain reaction (qPCR) assays were used to detect Mycoplasma haemofelis (Mhf), “Candidatus Mycoplasma haemominutum” (CMhm) and “Candidatus Mycoplasma turicensis” (CMt). The population was tested for four FVBP including Bartonella henselae and Leishmania spp. using qPCR, while conventional PCR assays were used to detect Ehrlichia/Anaplasma spp. and Hepatozoon spp. Serological assays were performed to detect Leishmania infantum antibodies, feline leukaemia virus (FeLV) antigen and feline immunodeficiency virus (FIV) antibodies. Statistical analysis was performed to test associations and possible risk factors between variables and infectious agents.ResultsNinety-six (55.2%) of the 174 cats were PCR-positive for at least one infectious agent. Forty-six cats (26.4%) were haemoplasma positive, including 13 (7.5%) for Mhf, 36 (20.7%) for CMhm and 12 (6.9%) for CMt. Sixty-six cats (37.9%) were positive for Hepatozoon spp., while 19 (10.9%) were positive for B. henselae, four (2.3%) for Leishmania spp. and one (0.6%) for Ehrlichia/Anaplasma spp. Sequencing revealed the presence of Hepatozoon felis, L. infantum and Anaplasma platys. Of the 164 cats that underwent retroviral serology, 10 (6.1%) were FeLV-positive and 31 (18.9%) were FIV-positive, while L. infantum serology was positive in 7 (4.4%) of the 160 cats tested. Multivariable logistic regression revealed significant associations for various infectious agents including L. infantum with each of Hepatozoon spp. and CMt infection.ConclusionsA high prevalence of infectious agents was found in cats from Cyprus with Mhf, CMhm, CMt, L. infantum, B. henselae, H. felis, A. platys, FeLV and FIV infections reported for the first time. The significant associations between different pathogens provide a better understanding of similarities in the epidemiology of these pathogens and interactions between them.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2063-2) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 49%

“…There are sporadic reports of this canine pathogen in cats from North America and Brazil [7, 56, 57], and recently A. platys- like strains were identified in cats from Sardinia, Italy [58]. In this study, we report a case of presumptive A. platys infection in a cat from Cyprus based on partial sequencing of 16S rRNA gene.…”

Section: Discussionmentioning

confidence: 91%

Prevalence study and risk factor analysis of selected bacterial, protozoal and viral, including vector-borne, pathogens in cats from Cyprus

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Because Bartonella spp. occur as co‐infections with other vector‐borne organisms, comprehensive serology and PCR testing should be considered when pursuing a diagnosis of vector‐borne illness …”

Section: Clinical Findingsmentioning

confidence: 99%

“…51 Monoclonal gammopathies have been reported in association with bartonellosis in cats, dogs and humans. 52,53 In a study that compared Bartonella bacteraemic dogs to non-Bartonella bacteraemic dogs, suspected of a vectorborne infection, hypogammaglobulinemia was the only statistically significant laboratory finding that discriminated between the two groups. 47 Similar to cats and humans, Bartonella bacteraemia can be detected in healthy dogs being screened as blood donors.…”

Section: Clinical Findingsmentioning

confidence: 99%

Bartonellosis, One Health and all creatures great and small

Breitschwerdt

2017

Veterinary Dermatology

113

118

View full text Add to dashboard Cite

Background Bartonellosis is a zoonotic infectious disease of worldwide distribution, caused by an expanding number of recently discovered Bartonella spp. Objectives This review serves as an update on comparative medical aspects of this disease, including the epidemiology, pathogenesis, clinical diagnosis, treatment and challenges. Results Of comparative medical importance, Bartonella spp. are transmitted by several arthropod vectors, including fleas, keds, lice, sand flies, ticks and, potentially, mites and spiders. Prior to 1990, there was only one named Bartonella species (B. bacilliformis), whereas there are now over 36, of which 17 have been associated with an expanding spectrum of animal and human diseases. Recent advances in diagnostic techniques have facilitated documentation of chronic bloodstream and dermatological infections with Bartonella spp. in healthy and sick animals, in human blood donors, and in immunocompetent and immunocompromised human patients. The field of Bartonella research remains in its infancy and is rich in questions, for which patient relevant answers are badly needed. Directed Bartonella research could substantially reduce a spectrum of chronic and debilitating animal and human diseases, and thereby reduce suffering throughout the world. Conclusion A One Health approach to this emerging infectious disease is clearly needed to define disease manifestations, to establish the comparative infectious disease pathogenesis of this stealth pathogen, to validate effective treatment regimens and to prevent zoonotic disease transmission.

show abstract

“…51 Monoclonal gammopathies have been reported in association with bartonellosis in cats, dogs and humans. 52,53 In a study that compared Bartonella bacteraemic dogs to nonBartonella bacteraemic dogs, suspected of a vector-borne infection, hypogammaglobulinemia was the only statistically significant laboratory finding that discriminated between the two groups. 47 Similar to cats and humans, Bartonella bacteraemia can be detected in healthy dogs being screened as blood donors.…”

Section: Clinical Findingsmentioning

confidence: 99%

Bartonellosis, One Health and all creatures great and small

Breitschwerdt

2017

Advances in Veterinary Dermatology

View full text Add to dashboard Cite

Background -Bartonellosis is a zoonotic infectious disease of worldwide distribution, caused by an expanding number of recently discovered Bartonella spp.Objectives -This review serves as an update on comparative medical aspects of this disease, including the epidemiology, pathogenesis, clinical diagnosis, treatment and challenges.Results -Of comparative medical importance, Bartonella spp. are transmitted by several arthropod vectors, including fleas, keds, lice, sand flies, ticks and, potentially, mites and spiders. Prior to 1990, there was only one named Bartonella species (B. bacilliformis), whereas there are now over 36, of which 17 have been associated with an expanding spectrum of animal and human diseases. Recent advances in diagnostic techniques have facilitated documentation of chronic bloodstream and dermatological infections with Bartonella spp. in healthy and sick animals, in human blood donors, and in immunocompetent and immunocompromised human patients. The field of Bartonella research remains in its infancy and is rich in questions, for which patient relevant answers are badly needed. Directed Bartonella research could substantially reduce a spectrum of chronic and debilitating animal and human diseases, and thereby reduce suffering throughout the world.

show abstract

Co-infection with Anaplasma platys, Bartonella henselae, Bartonella koehlerae and ‘Candidatus Mycoplasma haemominutum’ in a cat diagnosed with splenic plasmacytosis and multiple myeloma

Cited by 32 publications

References 42 publications

Prevalence study and risk factor analysis of selected bacterial, protozoal and viral, including vector-borne, pathogens in cats from Cyprus

Prevalence study and risk factor analysis of selected bacterial, protozoal and viral, including vector-borne, pathogens in cats from Cyprus

Bartonellosis, One Health and all creatures great and small

Bartonellosis, One Health and all creatures great and small

Contact Info

Product

Resources

About