Co‐infection with COVID‐19 and <i>influenza A</i> virus in two died patients with acute respiratory syndrome, Bojnurd, Iran

Hashemi, Seyed Ahmad; Safamanesh, Saghar; Ghafouri, Majid; Taghavi, Mohamad Reza; Heydari, Mina Sadat Mohajer Zadeh; Ahmadabad, Hasan Namdar; Ghasemzadeh‐Moghaddam, Hamed; Azimian, Amir

doi:10.1002/jmv.26014

Cited by 70 publications

(66 citation statements)

References 5 publications

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“…Moreover, we have seen a dramatic decline on the circulating respiratory viruses, likely due to the impact of social distancing measures on respiratory virus transmission 7 . Additionally, consistent with the results from Hashemi, et.al and Ozaras et.al, 6,8 the clinical manifestations in patients coinfected SARS‐CoV‐2 with influenza present similar symptoms with single SARS‐CoV‐2 infection, which further indicates that timely influenza virus detection in patients with COVID‐19 is necessary so as to distinguish other respiratory pathogen infection and take appropriate treatment measures earlier. Notably, it was found that patients coinfected with SARS‐CoV‐2 and influenza B virus were more likely to develop into severe‐type illness compared with those coinfected with influenza A virus and single SARS‐CoV‐2 infection.…”

Section: Discussionsupporting

confidence: 85%

The epidemiology and clinical characteristics of co‐infection of SARS‐CoV‐2 and influenza viruses in patients during COVID‐19 outbreak

Yue

Zhang

Liu

et al. 2020

Journal of Medical Virology

161

139

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In this study, we performed a single-centered study of 307 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. It was found that co-infection of SARS-CoV-2 and influenza virus was common during COVID-19 outbreak. And patients coinfected with SARS-CoV-2 and influenza B virus have a higher risk of developing poor outcomes so a detection of both viruses was recommended during COVID-19 outbreak.

show abstract

Section: Discussionsupporting

confidence: 85%

The epidemiology and clinical characteristics of co‐infection of SARS‐CoV‐2 and influenza viruses in patients during COVID‐19 outbreak

Yue

Zhang

Liu

et al. 2020

Journal of Medical Virology

161

139

View full text Add to dashboard Cite

show abstract

“…If individuals are coinfected with both SARS-CoV-2 and influenza, this could lead to more severe disease outcomes. Since the beginning of the SARS-CoV-2 pandemic, a number of case reports of SARS-CoV-2 and influenza coinfection with severe outcomes have been published 1,[9][10][11][12][13] . However, there is a propensity for case reports to highlight more severe cases and there has been no systematic analysis of disease outcomes in coinfected patients compared to non-coinfected controls.…”

Section: Introductionmentioning

confidence: 99%

Interactions between SARS-CoV-2 and Influenza and the impact of coinfection on disease severity: A test negative design

Stowe

Tessier

Zhao

et al. 2020

Preprint

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Background: The potential impact of COVID-19 alongside influenza on morbidity, mortality and health service capacity is a major concern as the Northern Hemisphere winter approaches. This study investigates the interaction between influenza and COVID-19 during the latter part of the 2019-20 influenza season in England. Methods: Individuals tested for influenza and SARS-CoV-2 were extracted from national surveillance systems between 20/01/2020 and 25/04/2020. To estimate influenza infection on the risk of SARS-CoV-2 infection, univariable and multivariable analyses on the odds of SARS-CoV-2 in those who tested positive for influenza compared to those who tested negative for influenza. To assess whether a coinfection was associated with severe SARS-CoV-2 outcome, univariable and multivariable analyses on the odds of death adjusted for age, sex, ethnicity, comorbidity and coinfection status. Findings: The risk of testing positive for SARS-CoV-2 was 68% lower among influenza positive cases, suggesting possible pathogenic competition between the two viruses. Patients with a coinfection had a risk of death of 5.92 (95% CI, 3.21-10.91) times greater than among those with neither influenza nor SARS-CoV-2 suggesting possible synergistic effects in coinfected individuals. The odds of ventilator use or death and ICU admission or death was greatest among coinfection patients showing strong evidence of an interaction effect compared to SARS-CoV-2/influenza acting independently. Interpretation: Cocirculation of these viruses could have a significant impact on morbidity, mortality and health service demand. Testing for influenza alongside SARS-CoV-2 and maximising influenza vaccine uptake should be prioritised to mitigate these risks.

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“…Influenza and COVID-19 can present with similar symptoms, and co-infections with a more severe course, complications or a fatal outcome have been recorded [11] , [12] . Beyond that, COVID-19 and seasonal influenza share the same high-risk groups and both can prove detrimental for older persons and persons with chronic co-morbidities, including obese persons and residents of long-term care facilities [13] , [14] .…”

mentioning

confidence: 99%

Influenza immunization and COVID-19

Maltezou

Theodoridou

Poland

2020

Vaccine

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Co‐infection with COVID‐19 and influenza A virus in two died patients with acute respiratory syndrome, Bojnurd, Iran

Cited by 70 publications

References 5 publications

The epidemiology and clinical characteristics of co‐infection of SARS‐CoV‐2 and influenza viruses in patients during COVID‐19 outbreak

The epidemiology and clinical characteristics of co‐infection of SARS‐CoV‐2 and influenza viruses in patients during COVID‐19 outbreak

Interactions between SARS-CoV-2 and Influenza and the impact of coinfection on disease severity: A test negative design

Influenza immunization and COVID-19

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