Co-infection and Clinical Impact of Human Herpesvirus 5 and 6 in Liver Transplantation

Sampaio, Aline Araújo; Guardia, A.C.; Milan, Arlete; Sasaki, Akira; Andrade, Paula Durante; Bonon, Sandra Helena Alves; Stucchi, Raquel Silveira Bello; Costa, Sueli I. R.; Boin, I.F.S.F.

doi:10.1016/j.transproceed.2012.07.034

Cited by 16 publications

(15 citation statements)

References 23 publications

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“…Co-infections are frequently detected in immunocompromised patients as the altered host immune response is unable to control latent viruses (Bissinger et al, 2005; Pliquett et al 2012). However, the exact implications of co-infections with regard to the pathogenesis of transplantation-associated diseases are not well known (Sampaio et al, 2012). In the present study, CMV was associated with viral co-infections in blood, which may be predictable, since CMV replication is known to increase the risk of other opportunistic infections (50).…”

Section: Discussionmentioning

confidence: 99%

Prospective, comprehensive, and effective viral monitoring in Cuban children undergoing solid organ transplantation

et al. 2014

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PurposeIn Cuba, viral monitoring in the post-transplant period was not routinely performed. The aim of this research is to identify the most frequent viruses that affect transplanted Cuban children, by implementing a viral follow-up during the post-transplant period.MethodsThe study population included all Cuban pediatric patients who underwent solid organ transplantation (SOT) between November 2009 and December 2012. A total of 34 transplanted pediatric patients of kidney (n = 11) and liver (n = 23) were prospectively monitored during a 34-week period for viral DNAemia and DNAuria by simultaneous detection of cytomegalovirus (CMV), Epstein-Barr virus, herpes simplex virus type 1 and 2, varicella zoster virus, human herpesvirus 6, human adenovirus, and polyomaviruses (BKV and JCV) using quantitative real-time polymerase chain reaction (qRT-PCR).ResultsViral genome of at least one virus was detected in 21 of 34 recipients, 18 patients excreted virus in urine while 12 presented DNAemia. CMV (41.2%) and BKV (35.3%) were the most frequent viruses detected during the follow-up. CMV was the virus mainly associated with clinical symptoms and DNAemia. Its excretion in urine (with cut off value of 219 copies/mL) was associated with detection in plasma (p < 0.001); furthermore, CMV viruria was predictive of CMV viremia (OR:8.4, CI:2.4-29.1, p = 0.001). There was no association between high viral load and clinical complications, due to the prompt initiation of preemptive ganciclovir. Conclusion: This comprehensive viral monitoring program effectively prevents the development of critical viral disease, thus urge the implementation of qRT-PCR as routine for viral monitoring of transplanted Cuban organ recipients.

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Section: Discussionmentioning

confidence: 99%

Prospective, comprehensive, and effective viral monitoring in Cuban children undergoing solid organ transplantation

et al. 2014

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“…47 Of the six patients who displayed an acute cellular rejection episode, four had concomitant bacterial infections and three experienced graft rejection episodes. 47 Those who reactivated HHV-6 were 3.5 times (P=.02) more likely to suffer from severe CMV-associated disease. 48 In a prospective study of 33 consecutive liver transplants, HHV-6 was detected in PBMCs by qualitative PCR in 11 (33%) patients.…”

Section: Co-infection and Diseasementioning

confidence: 99%

“…A 2012 study of 45 liver transplant recipients reported CMV infection in 23 (51.1%) and HHV‐6 infection in 12 (26.7%) patients . Of the six patients who displayed an acute cellular rejection episode, four had concomitant bacterial infections and three experienced graft rejection episodes . Those who reactivated HHV‐6 were 3.5 times ( P =.02) more likely to suffer from severe CMV‐associated disease .…”

Section: Conditions Associated With Hhv‐6 In Liver Transplant Patientsmentioning

confidence: 99%

“…HHV‐6 antigenaemia regularly precedes CMV antigenaemia and has been implicated as the probable cause of graft dysfunction . A 2012 study of 45 liver transplant recipients reported CMV infection in 23 (51.1%) and HHV‐6 infection in 12 (26.7%) patients . Of the six patients who displayed an acute cellular rejection episode, four had concomitant bacterial infections and three experienced graft rejection episodes .…”

Section: Conditions Associated With Hhv‐6 In Liver Transplant Patientsmentioning

confidence: 99%

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HHV‐6 in liver transplantation: A literature review

Phan

Lautenschlager

Razonable

et al. 2017

Liver International

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Human herpesvirus 6 (HHV-6A and HHV-6B) can cause primary infection or reactivate from latency in liver transplant recipients, which can result in a variety of clinical syndromes, including fever, hepatitis, encephalitis and higher rates of graft dysfunction as well as indirect effects including increased risks of mortality, CMV disease, hepatitis C progression and greater fibrosis scores. Although HHV-6 infection is currently diagnosed by quantifying viral DNA in plasma or blood, biopsy to demonstrate

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“…The coinfection of HCMV and HHV-6 often results in severe morbidity in SOTs [136,137]. Prospective studies are required to investigate the influence of other herpesvirus on reactivation of HCMV in patients with clinical complications.…”

Section: Pathophysiology Relevance Of Hcmv Latencymentioning

confidence: 99%

Epigenetic Regulation of Human Cytomegalovirus Latency: an Update

Kumar

Herbein

2014

Epigenomics

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Human cytomegalovirus (HCMV) is a ubiquitous virus which infects 50-90% of the population worldwide. In immunocompetent hosts, HCMV either remains unnoticed or causes mild symptoms. Upon primary infection it establishes latent infection in a few cells. However, in certain situations where immunity is either immature or compromised, HCMV may reactivate and cause mortality and morbidity. Therefore, it is utmost important to understand how HCMV establishes latent infection and associated mechanisms responsible for its reactivation. Several mechanisms are involved in the regulation of latency including chromatin remodeling by an array of enzymes and microRNAs. Here we will describe the epigenetic regulation of HCMV latency. Further we will discuss the unique HCMV latency signature and patho-physiological relevance of latent HCMV infection.

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Co-infection and Clinical Impact of Human Herpesvirus 5 and 6 in Liver Transplantation

Abstract: HHV-5/6-infected patients displayed more allograft rejection episodes, coinfections, and concomitant bacterial infections, besides an higher risk for CMV disease.

Cited by 16 publications

References 23 publications

Prospective, comprehensive, and effective viral monitoring in Cuban children undergoing solid organ transplantation

Prospective, comprehensive, and effective viral monitoring in Cuban children undergoing solid organ transplantation

HHV‐6 in liver transplantation: A literature review

Epigenetic Regulation of Human Cytomegalovirus Latency: an Update

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