Co-Expression of Cyclooxygenase-2 and Vascular Endothelial Growth Factor in Inflamed Human Pulp: An Immunohistochemical Study

Vascular Endothelial Growth Factor Receptor–2 Expression in the Pulp of Human Primary and Young Permanent Teeth

“…The uniform immunostaining observed in some endothelial cells could be solely explained by the receptor's physiologic expression. Güven et al (30), with immunohistochemistry, found moderate expression of the protein VEGF in the pulps of sound third molars. Those authors suggested that this expression would be indicative of physiologic pulpal angiogenesis, which corroborates the findings of the present study referring to VEGFR-2.…”

“…The presence of a co-receptor on the cell surface is required for signal transmission of LTA and LPS molecules. Toll-like receptor-4 is a necessary co-receptor to transmit LPS signal (29), and toll-like receptor-2 might be a signal component of a cellular LTA receptor (30).…”

Host–Mineral Trioxide Aggregate Inflammatory Molecular Signaling and Biomineralization Ability

“…Vascular endothelial growth factor (VEGF) is a glycoprotein with the ability to increase the permeability of blood vessels, an important vascular change observed during inflammation (12). Therefore, VEGF also plays a critical role in angiogenesis and neovascularization by participating in critical biological processes, such as tissue repair (13).…”

The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients

“…VEGF is a prominent GF for angiogenesis, a process fundamental for both tissue development and wound healing (1). VEGF expression in the cells of normal healthy pulp and in the cases of irreversible pulpitis was detected immunohistochemically (8,9). Studies with experimentally induced inflammation or hypoxia of pulp tissue reported increased the expression of VEGF in different pulp cells (10)(11)(12).…”