Co-exposure to environmental lead and manganese affects the intelligence of school-aged children

Kim, Yeni; Kim, Boong Nyun; Hong, Yun–Chul; Shin, Min-Sup; Yoo, Hee Jeong; Kim, Jae-Won; Bhang, Soo-Young; Cho, Soo Churl

doi:10.1016/j.neuro.2009.03.012

Cited by 160 publications

(128 citation statements)

References 51 publications

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“…27 Some of the chemicals, such as lead and manganese, may have direct effects on brain functioning and hence children's ability to perform well in school. 28 However, chemicals that have other health effects, including carcinogens and those that increase the risk of respiratory disorders, may also result in absences from school and otherwise impair students' ability to perform well.…”

Section: Study Resultsmentioning

confidence: 99%

Air Pollution Around Schools Is Linked To Poorer Student Health And Academic Performance

et al. 2011

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Exposing children to environmental pollutants during important times of physiological development can lead to long-lasting health problems, dysfunction, and disease. The location of children's schools can increase their exposure. We examined the extent of air pollution from industrial sources around public schools in Michigan to find out whether air pollution jeopardizes children's health and academic success. We found that schools located in areas with the highest air pollution levels had the lowest attendance rates-a potential indicator of poor health-and the highest proportions of students who failed to meet state educational testing standards. Michigan and many other states currently do not require officials considering a site for a new school to analyze its environmental quality. Our results show that such requirements are needed. For schools already in existence, we recommend that their environmental quality should be investigated and improved if necessary.

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Section: Study Resultsmentioning

confidence: 99%

Air Pollution Around Schools Is Linked To Poorer Student Health And Academic Performance

et al. 2011

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“…The neurotoxicity of Mn has been associated with deregulation of dopaminergic and cholinergic neurotransmitter release (Finkelstein et al 2007). Kim et al (2009) showed for the first time a possible additive interaction and effect modification of environmental Pb and Mn co-exposure on the Full-Scale IQ and verbal IQ of school-aged children. The synergism between manganese and lead on neurodevelopment was also observed during early childhood that is a potentially sensitive developmental stage.…”

Section: The Effects Of Metal Co-exposurementioning

confidence: 81%

“…There is growing evidence that co-exposure to heavy metals may exert adverse effects on neurodevelopment through common pathways (Kim et al 2009;Wasserman et al 2011;Claus Henn et al 2012;Rodríguez-Barranco et al 2013). Metals often co-occur in the environment, particularly in urban or industrial regions, as well as in socioeconomically disadvantaged populations or living near hazardous waste sites .…”

Section: The Effects Of Metal Co-exposurementioning

confidence: 99%

“…Furthermore, in the utero, co-exposure to Mn and Pb increased detrimental effects on cognitive and language development in children at 2 years of age (Lin et al 2013). The two metals may synergistically act in neurodevelopment through common pathways including affection of mitochondrial function and alteration of neurotransmitters release and synaptic depolarization (Kim et al 2009). Previously, rats exposed to a mixture of Pb and Mn during pre-and postnatal life showed significant alterations in the body; brain weights; content of DNA, RNA, protein; and accumulation of both metals in the brain (Chandra et al 1983).…”

Section: The Effects Of Metal Co-exposurementioning

confidence: 99%

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The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Gorini

Muratori

Morales

2014

Rev J Autism Dev Disord

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An increasing evidence supports the role of industrial chemicals as contributors to the development of neurobehavioral disorders, including autism spectrum disorders, whose prevalence has progressively increased in recent years. Heavy metals, in particular, are recognized as neurodevelopmental toxins since they can be responsible of fetal damages which lead to neurological defects, developmental delays, learning disabilities and behavioral abnormalities. Most of the reviewed studies reported a relationship between exposure to metals during perinatal and early childhood periods and increased risk for autism. Moreover, the effects resulting from co-exposure to multiple metals should not be underestimated, especially in the assessment of children who live in developing countries or near heavily contaminated sites.

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“…There is some evidence, for example, that co-exposure to Cd and As produces greater renal damage than either metal alone (Nordberg et al, 2005). Similarly, As and Mn (Wright et al, 2006) or Mn and lead (Kim et al, 2009) may interact in producing neurotoxicity in children.…”

Section: Introductionmentioning

confidence: 99%

Concentration of metals in blood of Maine children 1–6 years old

Rice

Lincoln

Martha

et al. 2010

J Expo Sci Environ Epidemiol

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Blood lead concentrations are higher in young children than in other age groups, whereas little is known regarding concentrations of other metals in young children. We measured the concentrations of a suite of metals in the blood of children 1-6 years of age, and assessed potential differences by age, season, or region of Maine. We used blood submitted to the Maine State Health and Environmental Testing Laboratory for blood lead analysis to determine the concentrations of arsenic (As), antimony (Sb), cadmium (Cd), manganese (Mn), mercury (Hg), selenium (Se), tin (Sn), and uranium (U) in 1350 children 1-6 years of age. The essential metals Mn and Se were detected in all samples, and As and Sb were detected in 490% of samples. Hg was detected in approximately 60% of samples. U and Cd were less often detected in blood samples, at approximately 30% and 10% of samples, respectively. Sn was not detected in any sample. Concentrations of As, Hg, and Se increased with age, whereas Sb decreased with age. Concentrations also varied by season and region for some though not all metals. Significant pairwise correlations were observed for a number of metals. Blood is a reasonable compartment for measurement of most of these metals in young children. The use of convenience samples provided a cost-effective mechanism for assessing exposure of young children in Maine.

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Co-exposure to environmental lead and manganese affects the intelligence of school-aged children

Cited by 160 publications

References 51 publications

Air Pollution Around Schools Is Linked To Poorer Student Health And Academic Performance

Air Pollution Around Schools Is Linked To Poorer Student Health And Academic Performance

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Concentration of metals in blood of Maine children 1–6 years old

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