Co-delivery of oxygen and erlotinib by aptamer-modified liposomal complexes to reverse hypoxia-induced drug resistance in lung cancer

Li, Fengqiao; Mei, Hao; Gao, Yu; Xie, Xiaodong; Nie, Huifang; Li, Tao; Zhang, Huijuan; Jia, Lee

doi:10.1016/j.biomaterials.2017.08.030

Cited by 140 publications

(88 citation statements)

References 78 publications

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“…Li and co-workers formulated liposomes with anti-EGFR aptamerconjugated-chitosan to deliver erlotinib and oxygen to reverse drug resistance caused by hypoxia in case of lung cancer. These liposomes are shown to have improved stability and additionally provided controlled discharge of drugs [32]. Garbuzenko and team formulated neutral and cationic liposomes to carry doxorubicin (DOX), ASO and siRNA and compared the intratracheal delivery of both these liposomes with that of systemic administration.…”

Section: Liposomesmentioning

confidence: 99%

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

Mehta

Deeksha

Tewari

et al. 2019

Chemico-Biological Interactions

306

112

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Section: Liposomesmentioning

confidence: 99%

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

Mehta

Deeksha

Tewari

et al. 2019

Chemico-Biological Interactions

306

112

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“…To enhance tumor targeting, the nanovector surface is usually modified with a ligand [9] or antibody [10]. Aptamers identified by an in vitro selection procedure known as systematic evolution of ligands by exponential enrichment (SELEX) have broad medical applications as drug delivery ligands due to their low immunogenicity and toxicity, high binding affinity, specificity, and wide range of targets [11,12].…”

Section: Introductionmentioning

confidence: 99%

Overcoming Drug Resistance in Colon Cancer by Aptamer-Mediated Targeted Co-Delivery of Drug and siRNA Using Grapefruit-Derived Nanovectors

Yan

Tao

Jiang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Multidrug resistance (MDR) is the most common cause of chemotherapy failure. Upregulation of P-glycoprotein (P-gp) is one of the main mechanisms underlying MDR. Methods: In this study, we developed a targeted drug and small interfering (si)RNA co-delivery system based on specific aptamer-conjugated grapefruit-derived nanovectors (GNVs) that we tested in MDR LoVo colon cancer cells. The internalization of nanovectors in cancer cells was tested by fluorescence microscopy and flow cytometry. The anti-cancer activity in vitro was determined by colony formation and cell apoptosis assays. The biodistribution of nanovectors was analyzed by live imaging and the anti-cancer activity in vivo was observed. Results: GNVs loaded with aptamer increased doxorubicin (Dox) accumulation in MDR LoVo cells, an effect that was abolished by pretreatment with DNase. The LA1 aptamer effectively promoted nanovector internalization into cells at 4°C and increased the targeted delivery of Dox to tumors. Constructs harboring Dox, LA1, and P-gp siRNA more effectively inhibited proliferation and enhanced apoptosis in cultured MDR LoVo cells while exhibiting more potent anti-tumor activity in vivo than free Dox or GNVs loaded with Dox alone or in conjunction with LA1, an effect that was associated with downregulation of P-gp expression. Conclusion: This GNV-based system may be an effective strategy for overcoming MDR in clinical settings.

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“…The most promising property of MNBs is efficient gas solubility inside the shell [45]. The core usually consists of a medical gas, while the shell is composed of biomolecules, such as lipids, proteins, polymers, and surfactants [12,46,47]. MNBs oscillate when acoustic waves are applied owing to the difference in the density of the gas and surrounding aqueous solution [48].…”

Section: Characteristics and Compositions Of Mnbsmentioning

confidence: 99%

Applications of Oxygen-Carrying Micro/Nanobubbles: a Potential Approach to Enhance Photodynamic Therapy and Photoacoustic Imaging

Khan¹,

Hwang²,

Lee³

et al. 2018

Preprint

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Microbubbles and nanobubbles can be prepared using various shells, such as phospholipids, polymers, proteins, and surfactants. They are echogenic and can be used as contrast agents for ultrasonic and photoacoustic imaging. These bubbles can be engineered in various sizes as vehicles for gas and drug delivery applications with novel properties and flexible structures. Hypoxic areas in tumors develop owing to an imbalance of oxygen supply and demand. In tumors, hypoxic regions have shown more resistance to chemotherapy, radiotherapy, and photodynamic therapies. The efficacy of photodynamic therapy depends on the availability of oxygen in the tumor to generate reactive oxygen species. Micro/nanobubbles have been shown to reverse hypoxic conditions and increase tissue oxygen levels. This review summarizes the synthesis methods and shell compositions of micro/nanobubbles and methods deployed for oxygen delivery. In addition, the shortcomings and prospects of engineering micro/nanobubbles are discussed for their potential use in photodynamic therapy.

show abstract

Co-delivery of oxygen and erlotinib by aptamer-modified liposomal complexes to reverse hypoxia-induced drug resistance in lung cancer

Cited by 140 publications

References 78 publications

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

Overcoming Drug Resistance in Colon Cancer by Aptamer-Mediated Targeted Co-Delivery of Drug and siRNA Using Grapefruit-Derived Nanovectors

Applications of Oxygen-Carrying Micro/Nanobubbles: a Potential Approach to Enhance Photodynamic Therapy and Photoacoustic Imaging

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