Co-delivery of bufalin and nintedanib via albumin sub-microspheres for synergistic cancer therapy

Xu, Ying; Liu, Yulong; Liu, Qi; Lu, Shengzhe; Chen, Xiaolin; Xu, Wenrong; Shi, Feng

doi:10.1016/j.jconrel.2021.08.049

Cited by 25 publications

(18 citation statements)

References 42 publications

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“…In recent years, studies have shown that Graphene (Deb et al., 2018 ), gold nanocages (Zhang et al., 2018b ), hydrogels (Ren et al., 2019 ; Wang et al., 2019b ; Abedi et al., 2021 ), prodrug nanogel (Ma et al., 2022 ), microspheres (Liu et al., 2017 ; Xu et al., 2021 ) and nanoclusters (He et al., 2020 ) can also be used for the co-delivery of natural active ingredients of and chemotherapy drugs. A summary of the researches of other nanocarriers used to co-deliver chemotherapy drugs and natural active ingredients is shown in Table 9 .…”

Section: Types and Characteristics Of Ndcdsmentioning

confidence: 99%

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Shao

et al. 2022

Drug Delivery

101

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Chemotherapy drugs have been used for a long time in the treatment of cancer, but serious side effects are caused by the inability of the drug to be solely delivered to the tumor when treating cancer with chemotherapy. Natural products have attracted more and more attention due to the antitumor effect in multiple ways, abundant resources and less side effects. Therefore, the combination of natural active ingredients and chemotherapy drugs may be an effective antitumor strategy, which can inhibit the growth of tumor and multidrug resistance, reduce side effects of chemotherapy drugs. Nano-drug co-delivery system (NDCDS) can play an important role in the combination of natural active ingredients and chemotherapy drugs. This review provides a comprehensive summary of the research status and application prospect of nano-delivery strategies for the combination of natural active ingredients and chemotherapy drugs, aiming to provide a basis for the development of anti-tumor drugs.

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Section: Types and Characteristics Of Ndcdsmentioning

confidence: 99%

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Shao

et al. 2022

Drug Delivery

101

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“…Sub-microspheres have good water solubility and blood compatibility, and are expected to be candidates for oral administration [ 150 , 151 ]. Xu et al [ 152 ] developed multifunctional albumin sub-microspheres to co-deliver BF and nintedanib for tumor-targeted combination therapy with a particle size of 879 ± 56 nm. The biguanide and ursodeoxycholic acid dual-modified multifunctional albumin were synthesized to enhance the antitumor effect and tumor-targeting efficiency.…”

Section: Strategies To Improve Solubility and Bioavailabilitymentioning

confidence: 99%

Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides

Shao

et al. 2021

Molecules

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Toad venom contains a large number of bufadienolides, which have a variety of pharmacological activities, including antitumor, cardiovascular, anti-inflammatory, analgesic and immunomodulatory effects.. The strong antitumor effect of bufadienolides has attracted considerable attention in recent years, but the clinical application of bufadienolides is limited due to their low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored, such as structural modification, solid dispersion, cyclodextrin inclusion, microemulsion and nanodrug delivery systems, etc. In this review, we have tried to summarize the pharmacological activities and structure–activity relationship of bufadienolides. Furthermore, the strategies for solubility and bioavailability enhancement of bufadienolides also are discussed. This review can provide a basis for further study on bufadienolides.

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“…It can inhibit the proliferation of tumor cells, inhibit angiogenesis, induce apoptosis, stimulate cell differentiation, enhance tumor cell autophagy and reverse multidrug resistance. (Xu et al 2021;Chen et al 2021a, b, c;Zhang et al 2019Zhang et al , 1992Li et al 2021) More importantly, it has been reported that BU can inhibit tumor metastasis through the EMT pathway in hepatocellular carcinoma and gastric cancers. (Wang et al 2016;Zou et al 2021) Recently, it has been reported that BU can inhibit the migration of PA-1 and OAW28 ovarian cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Bufalin-loaded vitamin E succinate-grafted chitosan oligosaccharide/RGD-conjugated TPGS mixed micelles inhibit intraperitoneal metastasis of ovarian cancer

Siddique

Fan

et al. 2023

Cancer Nano

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Background Intraperitoneal metastasis is one of the major causes of the high mortality rate of ovarian cancer. Bufalin (BU) is an effective component of the traditional Chinese medicine Chansu that exerts antitumor effects, including metastasis inhibition. In our previous studies, we found that BU inhibited the migration and invasion of ovarian cancer cells. However, the application of BU is limited due to its insolubility, toxicity and imprecise targeting. The aim of this study was to use vitamin E succinate (VES)-grafted chitosan oligosaccharide (CSO)/arginine-glycine-aspartic acid peptide (RGD)-conjugated d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) mixed micelles (VeC/T-RGD MMs) to deliver BU to ovarian cancer cells to inhibit intraperitoneal metastasis. Moreover, the toxicity of BU was reduced by coating it with the mixed micelles to increase its biocompatibility for practical applications. Results The BU-loaded VeC/T-RGD MMs (BU@MMs) had an average diameter of 161 ± 1.4 nm, a zeta potential of 4.49 ± 1.54 mV and a loading efficiency of 2.54%. The results showed that these micelles inhibited cell proliferation, induced apoptosis, and reduced the migration and invasion of A2780 and SKOV3 cells. Further studies indicated that BU@MMs enhanced the levels of e-cadherin and decreased the expression levels of N-cadherin, vimentin and Snail in vitro. In addition, the mixed micelles effectively enhanced the anticancer effect and inhibited intraperitoneal metastasis in intraperitoneal metastatic models. The BU@MMs exhibited fewer toxic side effects than BU, indicating better biocompatibility and biosafety for in vivo applications. Conclusions Our studies show that BU@MMs are a potential multifunctional nano-drug delivery system that can effectively inhibit the intraperitoneal metastasis of ovarian cancer.

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Co-delivery of bufalin and nintedanib via albumin sub-microspheres for synergistic cancer therapy

Cited by 25 publications

References 42 publications

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides

Bufalin-loaded vitamin E succinate-grafted chitosan oligosaccharide/RGD-conjugated TPGS mixed micelles inhibit intraperitoneal metastasis of ovarian cancer

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