Co-circulating serotypes in a dengue fever outbreak: Differential hematological profiles and phylogenetic relationships among viruses

Carmo, Andréia Moreira dos Santos; Suzuki, Rodrigo Buzinaro; Cabral, Aline Diniz; Costa, Renata Torres da; Massari, Gabriela Pena; Riquena, Michele Marcondes; Fracasso, Hélio Augusto Alves; Eterovic, André; Marcili, Arlei; Sperança, Márcia Aparecida

doi:10.1016/j.jcv.2017.03.001

Cited by 6 publications

(6 citation statements)

References 39 publications

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“…The analysis of the laboratory profile of DENV cases showed some interesting differences. Although there was no difference in the white blood cell count in cases related to different serotypes, a finding previously reported by other authors [21], the frequency of thrombocytopenia (platelets less than 100,000/mm 3 )was higher in infections with DENV-1 and DENV-2 compared to DENV-3 (0.014, RR 1.2, 95% CI 1-1.4). Rodrigues da Costa Faria et al [22] in Brazil, also found that cases of DENV-2 exhibited higher decrease in platelets number.…”

Section: Discussionsupporting

confidence: 70%

Clinical manifestations of primary and secondary dengue in Paraguay and its relation to virus serotype

Lovera

Martínez-Cuellar

et al. 2019

J Infect Dev Ctries

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Introduction: Dengue virus (DENV) infection is currently a major cause of morbidity in the world, and its incidence has mainly increased during the last years in Latin America, including Paraguay. The objective of this study was to compare the clinical and laboratory findings of dengue and assess whether the serotype is a risk factor for severity. Methodology: We included patients ≤ 15 years old hospitalized with dengue at the Institute of Tropical Medicine, from Paraguay, from 2007 to 2018. Patients were classified according to the 2009 WHO dengue classification guidelines and were stratified by serotype into three groups according to the hospitalization period: the 2007 epidemic (DENV-3), the 2012-2013 epidemic (DENV-2) and the 2016-2018 epidemic (DENV-1). Results: Of 784 children hospitalized for dengue, 50 cases (6.3%) were caused by DENV-3, 471 (60%) by DENV-2, and 263 (33.5%) by DENV-1. Myalgias and headache were associated with DENV-3 cases and abdominal pain was associated with DENV-2 cases. Bleeding was observed mainly in DENV-1 and 2 cases. Patients with DENV-2 infections experienced more severe disease, required fluid expansion more frequently, and exhibited more often shock and admission in the ICU. Secondary cases of dengue were more severe that primary cases. Patients with infection by DENV-2 had longer hospital stays (5.1 ± 2.8 days) when compared to DENV-3 o DENV-1 infection cases (2.9 ± 1.6 days and 4.36 ± 2.7 days, respectively) (p < 0.05). Conclusions: The DENV serotype has a profound impact on the clinical manifestations and severity of dengue. DENV-2 infections were associated more frequently to requirement of fluid expansion, shock, and longer hospital stay.

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Section: Discussionsupporting

confidence: 70%

Clinical manifestations of primary and secondary dengue in Paraguay and its relation to virus serotype

Lovera

Martínez-Cuellar

et al. 2019

J Infect Dev Ctries

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“…In many countries of the Asian, African, and American continents, the mosquito Aedes aegypti Linnaeus, 1762 is the main vector of dengue, zika, urban yellow fever, and chikungunya (Aguirre-Obando et al 2016;Ahamed et al 2017). From environment contamination, the excessive use of synthetic insecticides also affects other non-target organisms (Carmo et al 2017;Haddi et al 2017). Therefore, the investigation of green sources containing bioactive compounds as botanicals with insecticidal properties represents an important alternative for controlling agent (Rapado et al 2014;Chandrasekaran et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsion Loaded with Volatile Oil from Piper alatipetiolatum as an Alternative Agent in the Control of Aedes aegypti

Oliveira

Sá

Mesquita

et al. 2020

Rev. Bras. Farmacogn.

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Diseases transmitted by the mosquito Aedes aegypti, Culicidae, are a serious public health problem worldwide, especially because of the increasing resistance to synthetic insecticides. Volatile oils are botanicals with interesting multi-target properties, but with reduced applications due to its volatility and water solubility. For this reason, nanoemulsions containing volatile oils are an important alternative for the mosquito control. The volatile oil of leaves Piper alatipetiolatum Yunck., Piperaceae, was characterized mostly by sesquiterpenes, such as ishwarone (78.6%), ishwarol B (8.2%), β-elemene (6.9%), selin-11-en-4α-ol (2.9%), and ishwarane (2.4%). The volatile oil showed lower ovicidal activity (19 to 100%), larvicidal activity (LC 50 33.74 ppm), and pupicidal activity (LC 50 65.06 ppm) as compared with its nanoemulsion that presented higher ovicidal activity (47.7 to 100%), larvicidal activity (LC 50 6.37 ppm), and pupicidal activity (LC 50 9.33 ppm) against Ae. aegypti. The volatile oil nanoemulsion was characterized with approximately spherical morphology, with an average size of 316 ± 8 nm, PDI of 0.44 ± 0.01, zeta potential of − 8.5 ± 0.1 mV, and pH of 5.3 ± 0.1. These results indicated that the nanoemulsion containing the encapsulated volatile oil was effective to interrupt the development of immature forms of Ae. aegypti and represents an efficient alternative tool to control this vector, contributing to vector control of dengue and other related diseases.

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“…In conclusion, developing a vaccine for DENV is arguably a challenging task because DENV infection tend to manifest in a more severe form after a previous infection with a heterologous DENV serotype. Additionally, the four serotypes of DENV could also be co-circulating at different prevalence rates in the same region and the pattern of DENV serotypes circulating in a region could also be vastly different from another region 100. The only available vaccine, CYD-TDV, appears to only elicit antibodies that are unable to neutralize heterologous DENV serotypes.…”

Section: Resultsmentioning

confidence: 99%

The Conserved Molecular Determinants of Virulence in Dengue Virus

Ahmad

Poh

2019

Int. J. Med. Sci.

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Dengue virus belongs to the Flaviviridae family which also includes viruses such as the Zika, West Nile and yellow fever virus. Dengue virus generally causes mild disease, however, more severe forms of the dengue virus infection, dengue haemorrhagic fever (DHF) and dengue haemorrhagic fever with shock syndrome (DSS) can also occur, resulting in multiple organ failure and even death, especially in children. The only dengue vaccine available in the market, CYD-TDV offers limited coverage for vaccinees from 9-45 years of age and is only recommended for individuals with prior dengue exposure. A number of mutations that were shown to attenuate virulence of dengue virus in vitro and/or in vivo have been identified in the literature. The mutations which fall within the conserved regions of all four dengue serotypes are discussed. This review hopes to provide information leading to the construction of a live attenuated dengue vaccine that is suitable for all ages, irrespective of the infecting dengue serotype and prior dengue exposure.

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Co-circulating serotypes in a dengue fever outbreak: Differential hematological profiles and phylogenetic relationships among viruses

Cited by 6 publications

References 39 publications

Clinical manifestations of primary and secondary dengue in Paraguay and its relation to virus serotype

Clinical manifestations of primary and secondary dengue in Paraguay and its relation to virus serotype

Nanoemulsion Loaded with Volatile Oil from Piper alatipetiolatum as an Alternative Agent in the Control of Aedes aegypti

The Conserved Molecular Determinants of Virulence in Dengue Virus

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