Co-assembly of FeTPP@Fe3O4 nanoparticles with photo-enhanced catalytic activity for synergistic tumor therapy

Tian, Tian; Bao, Jianshuai; Wang, Jinghan; Wang, Jiefei; Ge, Yan; Li, Zengyin; Gao, Shanqing; You, Zhongqi; Yang, Xiaoyan; Zhong, Yong; Bai, Feng

doi:10.1007/s12274-022-4548-3

Cited by 6 publications

(7 citation statements)

References 55 publications

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“…Under laser irradiation, the photothermal generated by FeTPP assemblies promotes POD performance of Fe 3 O 4 NPs, and instantaneously generates a large number of free hydroxyl groups to kill tumor cells (Figure 13B-F). These results clearly demonstrate that FeTPP@Fe 3 O 4 NPs can effectively accelerate the catalytic decomposition of endogenous H 2 O 2 in an acidic environment under laser irradiation, further accelerate the generation of •OH, and improve the CDT efficacy in vivo [19].…”

Section: Synergistic Chemo-photothermal Therapy Of Autpyp Self-assemb...mentioning

confidence: 63%

“…Copyright 2021 American Chemical Society. (H) Reproduced with permission from reference [19]. Copyright 2022 Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2022. solution/CHCl 3 as microemulsion droplet [18].…”

Section: Microemulsion-assisted/mesophase Transfer Self-assembly Methodsmentioning

confidence: 99%

“…More interestingly, the microemulsion droplet technology can well integrate the organic-inorganic interface, and then be used to construct the organic-inorganic composite coassemblies. Typically, the CHCl 3 solution of 5,10,15,20-tetraphenyl-21H, 23H-porphine iron (III) chloride (FeTPP) and oleic acid (OA) modified magnetic Fe 3 O 4 NCs was injected into SDS aqueous solution to create an oil-in-water microemulsion by an ultrasonic probe [19]. After evaporation of the chloroform solvent, the FeTPP and OA-Fe 3 O 4 NCs randomly coassembled into nanospheres driven by π-π stacking and hydrophobic-hydrophobic interactions (Figure 5H).…”

Section: Microemulsion-assisted/mesophase Transfer Self-assembly Methodsmentioning

confidence: 99%

“…(E) the corresponding Michaelis-Menten kinetics and (F) photo-enhanced POD-like activity of various nanoparticles. Reproduced with permission from reference[19]. Copyright 2022 Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2022.…”

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confidence: 99%

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Porphyrin Self-Assembled Nanostructures and Applications

Liu¹,

Li²,

Tong³

et al. 2023

Self-Assembly of Materials and Their Applications

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Porphyrins are a class of macromolecular heterocyclic compounds formed by the inter-carbon atoms of four pyrrole-like subunits through the submethyl bridge (〓CH▬). Porphyrin rings have 26 electrons in highly conjugated system and are easily modified peripheral structures, often serve as ideal building blocks to construct self-assembled nanostructures with excellent physical and chemical properties. Porphyrin nanostructures have excellent visible light absorption properties, which will significantly improve the efficiency of electron–hole separation, and are also commonly used in photocatalysis fields. Porphyrin photosensitizers have superior strong phototoxicity and little side effects, and are widely used in tumor photothermal/photodynamic treatment. This chapter summarizes the self-assembly methods of porphyrins, the applications progress of porphyrin self-assembled nanomaterials in photocatalysis and tumor therapy, and discusses the development trend in future of porphyrin nanomaterials.

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Section: Synergistic Chemo-photothermal Therapy Of Autpyp Self-assemb...mentioning

confidence: 63%

Section: Microemulsion-assisted/mesophase Transfer Self-assembly Methodsmentioning

confidence: 99%

Section: Microemulsion-assisted/mesophase Transfer Self-assembly Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Porphyrin Self-Assembled Nanostructures and Applications

Liu¹,

Li²,

Tong³

et al. 2023

Self-Assembly of Materials and Their Applications

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“…After incubation with the TAT-InTPP nanorods, the HeLa cells emitted strong green fluorescence, suggesting considerable 1 O 2 production from the nanorods. Then, the in vitro toxicity and phototherapeutic effects of the internalized TAT-InTPP nanorods were assessed using CCK-8 47 and calcein AM/PI costaining assays, 48 respectively. First, the cytotoxicity of the TAT-InTPP nanorods toward normal cells (Figure S20) and tumor cells (Figure 5b) was investigated.…”

Section: Resultsmentioning

confidence: 99%

Microemulsion-Assisted Self-Assembly of Indium Porphyrin Photosensitizers with Enhanced Photodynamic Therapy

Yang,

Liu,

Ren

et al. 2024

ACS Nano

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Designing and constructing supramolecular photosensitizer nanosystems with highly efficient photodynamic therapy (PDT) is vital in the nanomedical field. Despite recent advances in forming well-defined superstructures, the relationship between molecular arrangement in nanostructures and photodynamic properties has rarely been involved, which is crucial for developing stable photosensitizers for highly efficient PDT. In this work, through a microemulsion-assisted selfassembly approach, indium porphyrin (InTPP) was used to fabricate a series of morphology-controlled self-assemblies, including nanorods, nanospheres, nanoplates, and nanoparticles. They possessed structure-dependent 1 O 2 generation efficiency. Compared with the other three nanostructures, InTPP nanorods featuring strong π−π stacking, J-aggregation, and high crystallinity proved to be much more efficient at singlet oxygen ( 1 O 2 ) production. Also, theoretical modeling and photophysical experiments verified that the intermolecular π−π stacking in the nanorods could cause a decreased singlet− triplet energy gap (ΔE ST ) compared with the monomer. This played a key role in enhancing intersystem crossing and facilitating 1 O 2 generation. Both in vitro and in vivo experiments demonstrated that the InTPP nanorods could trigger cell apoptosis and tumor ablation upon laser irradiation (635 nm, 0.1 W/cm 2 ) and exhibited negligible dark toxicity and high phototoxicity. Thus, the supramolecular self-assembly strategy provides an avenue for designing high-performance photosensitizer nanosystems for photodynamic therapy and beyond.

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