Progress of Porphyrin-based Nanoassemblies for Cancer Theranostics

Wang, Mengyue; Guan, Huaijin; You, Zhongqi; Jia, Rong; Zhong, Yong; Bai, Feng

doi:10.1007/s40242-023-3127-9

Cited by 3 publications

(2 citation statements)

References 96 publications

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“…The complex tumor microenvironment (TME) causes easy metastasis, unlimited proliferation, and drug resistance of cancer cells, which leads the current cancer treatment methods including surgery, radiation, and chemotherapy to still face poor prognosis. − Chemodynamic therapy (CDT) involves metal ions that respond to the TME, such as acidic conditions (low pH) and overexpression of H 2 O 2 and glutathione (GSH), to induce the Fenton reaction to produce reactive oxygen species (ROS) . This reaction catalyzes H 2 O 2 to generate highly cytotoxic hydroxyl radicals (•OH), thus killing cancer cells .…”

Section: Introductionmentioning

confidence: 99%

Coordination Self-Assembled AuTPyP-Cu Metal–Organic Framework Nanosheets with pH/Ultrasound Dual-Responsiveness for Synergistically Triggering Cuproptosis-Augmented Chemotherapy

Bao,

Wang,

Chen

et al. 2024

ACS Nano

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Reactive oxygen species (ROS) mediated tumor cell death is a powerful anticancer strategy. Cuproptosis is a copper-dependent and ROS-mediated prospective tumor therapy strategy. However, the complex tumor microenvironment (TME), low tumor specificity, poor therapy efficiency, and lack of imaging capability impair the therapy output of current cuproptosis drugs. Herein, we designed a dual-responsive twodimensional metal−organic framework (2D MOF) nanotheranostic via a coordination self-assembly strategy using Au(III) tetra-(4-pyridyl) porphine (AuTPyP) as the ligand and copper ions (Cu 2+ ) as nodes. The dual-stimulus combined with the protonation of the pyridyl group in AuTPyP and deeppenetration ultrasound (US) together triggered the controlled release in an acidic TME. The ultrathin structure (3.0 nm) of nanotheranostics promoted the release process. The released Cu 2+ was reduced to Cu + by depleting the overexpressed glutathione (GSH) in the tumor, which not only activated the Ferredoxin 1 (FDX1)-mediated cuproptosis but also catalyzed the overexpressed hydrogen peroxide (H 2 O 2 ) in the tumor into reactive oxygen species via Fenton-like reaction. Simultaneously, the released AuTPyP could specifically bind with thioredoxin reductase and activate the redox imbalance of tumor cells. These together selectively induced significant mitochondrial vacuoles and prominent tumor cell death but did not damage the normal cells. The fluorescence and magnetic resonance imaging (MRI) results verified this nanotheranostic could target the HeLa tumor to greatly promote the self-enhanced effect of chemotherapy/cuproptosis and tumor inhibition efficiency. The work helped to elucidate the controlled assembly of multiresponsive nanotheranostics and the high-specificity ROS regulation for application in anticancer therapy.

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Section: Introductionmentioning

confidence: 99%

Coordination Self-Assembled AuTPyP-Cu Metal–Organic Framework Nanosheets with pH/Ultrasound Dual-Responsiveness for Synergistically Triggering Cuproptosis-Augmented Chemotherapy

Bao,

Wang,

Chen

et al. 2024

ACS Nano

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“…Because of their tuneable optoelectronic properties, porphyrins are also used in molecular recognition and metal-ion sensing applications (Ogoshi and Mizutani, 1999;Ishizuka et al, 2022). Moreover, features of porphyrinoids such as biocompatibility, biological function mimicking, extended residence in cancer cells, are appealing properties for biomedical applications (Tian et al, 2023;Wang et al, 2023;Wu et al, 2023). For instance, photodynamic therapy (PDT) is a field dominated by the utilization of porphyrins (Mrinalini et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Porphyrins—valuable pigments of life

Nikolaou,

Nikoloudakis,

Ladomenou

et al. 2024

Front. Chem. Biol.

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Porphyrin complexes are present in many natural systems and have significant biological roles, such as light harvesting, oxygen transport, and catalysis. Owing to their intrinsic aromatic structure, porphyrin derivatives exhibit characteristic photophysical and electrochemical properties. Porphyrins and porphyrin-based derivatives have been extensively utilized in biomedical applications during the last decade. Specifically, porphyrinoids have been tested as agents in antimicrobial and photodynamic therapy, as well as in imaging applications (e.g., diagnosis of cancer cells). This perspective article summarizes the recent developments in our group concerning the application of porphyrin derivatives in biomedical applications. The current challenges and future prospects concerning the exploitation of porphyrin-based materials in biomedical applications are also discussed.

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Rational Design of Coordination Polymers Composited Hollow Multishelled Structures for Drug Delivery

Xiao,

Shang,

Peng

et al. 2024

Small Methods

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Multifunctional drug delivery systems (DDS) are in high demand for effectively targeting specific cells, necessitating excellent biocompatibility, precise release mechanisms, and sustained release capabilities. The hollow multishelled structure (HoMS) presents a promising solution, integrating structural and compositional design for efficient DDS development amidst complex cellular environments. Herein, starting from a Fe‐based metal‐organic framework (MOF), amorphous coordination polymers (CP) composited HoMS with controlled shell numbers are fabricated by balancing the rate of MOF decomposition and shell formation. Fe‐CP HoMS loaded with DOX is utilized for synergistic chemotherapy and chemodynamic therapy, offering excellent responsive drug release capability (excellent pH‐triggered drug release 82% within 72 h at pH 5.0 solution with doxorubicin (DOX) loading capacity of 284 mg g−1). In addition to its potent chemotherapy attributes, Fe‐CP‐HoMS possesses chemodynamic therapy potential by continuously catalyzing H2O2 to generate ·OH species within cancer cells, thus effectively inhibiting cancer cell proliferation. DOX@3S‐Fe‐CP‐HoMS, at a concentration of 12.5 µg mL−1, demonstrates significant inhibitory effects on cancer cells while maintaining minimal cytotoxicity toward normal cells. It is envisioned that CP‐HoMS could serve as an effective and biocompatible platform for the advancement of intelligent drug delivery systems in the realm of cancer therapy.

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Progress of Porphyrin-based Nanoassemblies for Cancer Theranostics

Cited by 3 publications

References 96 publications

Coordination Self-Assembled AuTPyP-Cu Metal–Organic Framework Nanosheets with pH/Ultrasound Dual-Responsiveness for Synergistically Triggering Cuproptosis-Augmented Chemotherapy

Coordination Self-Assembled AuTPyP-Cu Metal–Organic Framework Nanosheets with pH/Ultrasound Dual-Responsiveness for Synergistically Triggering Cuproptosis-Augmented Chemotherapy

Porphyrins—valuable pigments of life

Rational Design of Coordination Polymers Composited Hollow Multishelled Structures for Drug Delivery

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