Co-Application with Tannic Acid Prevents Transdermal Sensitization to Ovalbumin in Mice

Abstract

Transdermal sensitization to allergens is of great concern as a sensitization route for food allergies. This skin-mediated invasion and sensitization to allergens is involved in skin barrier breakdown and inflammation, followed by the production of several kinds of cytokines. Cytokines such as thymic stromal lymphopoietin and thymus and activation-regulated chemokine are also involved. In this study, we investigated the suppressive effect of tannic acid (TA) on transdermal sensitization using ovalbumin (OVA), a major egg-white allergen. We also analyzed the mechanisms associated with the inhibitory effects of TA. The results showed that the co-application with TA prevents transdermal sensitization to OVA. As possible mechanisms, its anti-inflammatory and astringent effect on the skin and binding ability with the protein were considered. These results indicate that TA could be applied to cosmetics and lotions, which could suppress the transdermal sensitization to allergens.

Wet adhesive hydrogels based on niobium carbide for experimental research of oral mucosal impairment

“…Therefore, TA can aid in reducing the area of impairment and promoting healing during the treatment of oral mucosal impairments. 43 Last but not least, TA has antibacterial properties against Staphylococcus aureus and Escherichia coli . 44 Typically, photothermal materials alone require temperatures as high as 70 °C to effectively eradicate bacteria.…”