Synthesis of modified tannic acid hydrogel for the transdermal delivery of curcumin

Suresh, Athira B.; Rajeev, M.R.; Anirudhan, T.S.

doi:10.1016/j.jece.2023.109862

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…The Cur-Car-IL@Ilo hydrogel not only has the characteristics of IL but also has the unique moisture retention, adhesion, and pore structure of the hydrogel, which increases skin permeability. Moreover, after 24 h of penetration, the skin still maintains good skin integrity (Figure e), indicating that curcumin in Cur-Car-IL@Ilo hydrogel can effectively deliver through the skin and has potential application value in the local treatment of psoriasis. ,− …”

Section: Results and Discussionmentioning

confidence: 99%

“…It is believed to increase percutaneous absorption, reduce side effects, target breast cancer cells, and maximize drug cell compatibility. 23 To solve the above problems, a functional local transdermal drug delivery system based on a three-dimensional network hydrogel was prepared in this paper (Scheme 1). On the one hand, SA and HPMC are introduced into the threedimensional reticular hydrogel to prepare a pH-responsive functional hydrogel, which is used as a drug carrier system in transdermal preparations to provide continuous adhesion to the skin in various states, solve the contradiction between the cell affinity and stability, strong interface adhesion and high mechanical properties of traditional hydrogel carriers, and expand the application of hydrogels in the biomedical field.…”

Section: Introductionmentioning

confidence: 99%

“…Suresh et al synthesized a new chemically modified oleic acid silver-nanoparticle-conjugated poly(vinyl alcohol) tannic acid nanohydrogel for transdermal delivery of curcumin for cancer treatment. It is believed to increase percutaneous absorption, reduce side effects, target breast cancer cells, and maximize drug cell compatibility …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model

Lu,

Zhong,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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Psoriasis is a systemic, recurrent, chronic autoimmune skin disease. However, psoriasis drugs have poor skin permeability and high toxicity, resulting in low bioavailability and affecting their clinical application. In this study, we propose a curcumin-based ionic liquid hydrogel loaded with ilomastat (Cur-Car-IL@Ilo hydrogel), which can effectively maintain the sustained release of drugs and improve the skin permeability of drugs. We used a model of imiquimod-induced psoriasis and demonstrated that local application of Cur-Car-IL@Ilo hydrogel can improve skin lesions in mice with significantly reduced expression levels of inflammatory factors, matrix metalloproteinase 8, and collagen-I. The expressions of iron death-related proteins SLC7A11 and ASL4 were significantly decreased after treatment with Cur-Car-IL@Ilo hydrogel. Flora analysis showed that the content of anaerotruncus, proteus, and UCG-009 bacteria in the gut of psoriatic mice increased. The levels of paludicola, parabacteroides, prevotellaceae_UCG-001, escherichia-shigella, and aerococcus decreased, and the levels of some of the above bacteria tended to be normal after treatment. Therefore, the curcumin-based ionic liquid hydrogel can be used as a multifunctional, nonirritating, noninvasive, and highly effective percutaneous treatment of psoriasis.

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